Weight Reduction Increases Plasma Levels of an Adipose-Derived Anti-Inflammatory Protein, Adiponectin (original) (raw)

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1Department of Internal Medicine (W.-S.Y., C.-L.C., T.-Y.T., L.-M.C.), Taipei 100

2Graduate Institute of Clinical Medicine (W.-S.Y., L.-M.C.), College of Medicine, Taipei 100

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4Department of Surgery (W.-J.L.), En Chu Kong Hospital, Taipei Hsien 237, Taiwan

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5Department of Internal Medicine and Molecular Science (T.F., S.T., Y.M.), Graduate School of Medicine, Osaka University, 565-0871, Osaka, Japan

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5Department of Internal Medicine and Molecular Science (T.F., S.T., Y.M.), Graduate School of Medicine, Osaka University, 565-0871, Osaka, Japan

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5Department of Internal Medicine and Molecular Science (T.F., S.T., Y.M.), Graduate School of Medicine, Osaka University, 565-0871, Osaka, Japan

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1Department of Internal Medicine (W.-S.Y., C.-L.C., T.-Y.T., L.-M.C.), Taipei 100

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1Department of Internal Medicine (W.-S.Y., C.-L.C., T.-Y.T., L.-M.C.), Taipei 100

3Institute of Epidemiology (C.-L.C.), College of Public Health, National Taiwan University, Taipei 100

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1Department of Internal Medicine (W.-S.Y., C.-L.C., T.-Y.T., L.-M.C.), Taipei 100

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1Department of Internal Medicine (W.-S.Y., C.-L.C., T.-Y.T., L.-M.C.), Taipei 100

2Graduate Institute of Clinical Medicine (W.-S.Y., L.-M.C.), College of Medicine, Taipei 100

*Address all correspondence and requests for reprints to: Lee-Ming Chuang, M.D., Ph.D., Department of Internal Medicine, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei 100, Taiwan.

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Received:

12 February 2001

Published:

01 August 2001

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Wei-Shiung Yang, Wei-Jei Lee, Tohru Funahashi, Sachiyo Tanaka, Yuji Matsuzawa, Chia-Ling Chao, Chi-Ling Chen, Tong-Yuan Tai, Lee-Ming Chuang, Weight Reduction Increases Plasma Levels of an Adipose-Derived Anti-Inflammatory Protein, Adiponectin, The Journal of Clinical Endocrinology & Metabolism, Volume 86, Issue 8, 1 August 2001, Pages 3815–3819, https://doi.org/10.1210/jcem.86.8.7741
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Adiponectin, an adipose tissue-specific plasma protein, was recently revealed to have anti-inflammatory effects on the cellular components of vascular wall. Its plasma levels were significantly lower in men than in women and lower in human subjects with obesity, type 2 diabetes mellitus, or coronary artery disease. Therefore, it may provide a biological link between obesity and obesity-related disorders such as atherosclerosis, against which it may confer protection. In this study, we observed the changes of plasma adiponectin levels with body weight reduction among 22 obese patients who received gastric partition surgery. A 46% increase of mean plasma adiponectin level was accompanied by a 21% reduction in mean body mass index. The change in plasma adiponectin levels was significantly correlated with the changes in body mass index (r = −0.5, P = 0.01), waist (r = −0.4, P = 0.04) and hip (r =− 0.6, P = 0.0007) circumferences, and steady state plasma glucose levels (r = −0.5, P = 0.04). In multivariate linear regression models, the increase in adiponectin as a dependent variable was significantly related to the decrease in hip circumference (β = −0.16, P = 0.028), after adjusting body mass index and waist circumference. The change in steady state plasma glucose levels as a dependent variable was related to the increase of adiponectin with a marginal significance (β =− 0.92, P = 0.053), after adjusting body mass index and waist and hip circumferences. In conclusion, body weight reduction increased the plasma levels of a protective adipocytokine, adiponectin. In addition, the increase in plasma adiponectin despite the reduction of the only tissue of its own synthesis suggests that the expression of adiponectin is under feedback inhibition in obesity.

Copyright © 2001 by The Endocrine Society

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