Significant Human β-Cell Turnover Is Limited to the First Three Decades of Life as Determined by in Vivo Thymidine Analog Incorporation and Radiocarbon Dating (original) (raw)

S. Perl ,

1Diabetes Branch (S.Per., S.Pec., E.H.L., D.M.H.), National Institute of Diabetes, Digestive, and Kidney Disease (NIDDK), National Institutes of Health, Bethesda, Maryland 20892;

6Molecular and Clinical Hematology Branch (S.Per., M.H., J.F.T., M.K.), NIDDK and National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892

*Address all correspondence and requests for reprints to: Shira Y. Perl, M.D., 10 Center Drive, Room 9N119, Bethesda, Maryland 20892.

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J. A. Kushner ,

2Division of Endocrinology and Diabetes (J.A.K., G.M.S.), Children’s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104;

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B. A. Buchholz ,

3Center for Accelerator Mass Spectrometry (B.A.B.), Lawrence Livermore National Laboratory, Livermore, California 94550;

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A. K. Meeker ,

4Department of Pathology (A.K.M.), Division of Genitourinary Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287;

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G. M. Stein ,

2Division of Endocrinology and Diabetes (J.A.K., G.M.S.), Children’s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104;

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M. Hsieh ,

6Molecular and Clinical Hematology Branch (S.Per., M.H., J.F.T., M.K.), NIDDK and National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892

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M. Kirby ,

5National Human Genome Research Institute (M.K.), National Institutes of Health, Bethesda, Maryland 20892;

6Molecular and Clinical Hematology Branch (S.Per., M.H., J.F.T., M.K.), NIDDK and National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892

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S. Pechhold ,

1Diabetes Branch (S.Per., S.Pec., E.H.L., D.M.H.), National Institute of Diabetes, Digestive, and Kidney Disease (NIDDK), National Institutes of Health, Bethesda, Maryland 20892;

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E. H. Liu ,

1Diabetes Branch (S.Per., S.Pec., E.H.L., D.M.H.), National Institute of Diabetes, Digestive, and Kidney Disease (NIDDK), National Institutes of Health, Bethesda, Maryland 20892;

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D. M. Harlan

1Diabetes Branch (S.Per., S.Pec., E.H.L., D.M.H.), National Institute of Diabetes, Digestive, and Kidney Disease (NIDDK), National Institutes of Health, Bethesda, Maryland 20892;

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