Pharmacological actions of Cordyceps, a prized folk medicine (original) (raw)

Journal Article

,

Department of Biochemistry, Faculty of Medicine, The Chinese University of Hong Kong

, Shatin, New Territories, Hong Kong,

China

Correspondence: T. B. Ng, Department of Biochemistry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China. E-mail: b021770@mailserv.cuhk.edu.hk

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Department of Microbiology, China Agricultural University

, Beijing,

China

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Published:

18 February 2010

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Abstract

Cordyceps species, including C. sinensis, C. militaris, C. pruinosa and C. ophioglossoides, are prized traditional medicinal materials. The aim of this article is to review the chemical constituents and pharmacological actions of Cordyceps species. The chemical constituents include cordycepin (3′-deoxyadenosine) and its derivatives, ergosterol, polysaccharides, a glycoprotein and peptides containing α-aminoisobutyric acid. They include anti-tumour, anti-metastatic, immunomodulatory, antioxidant, anti-inflammatory, insecticidal, antimicrobial, hypolipidaemic, hypoglycaemic, anti-ageing, neuroprotective and renoprotective effects. Polysaccharide accounts for the anti-inflammatory, antioxidant, anti-tumour, anti-metastatic, immunomodulatory, hypoglycaemic, steroidogenic and hypolipidaemic effects. Cordycepin contributes to the anti-tumour, insecticidal and antibacterial activity. Ergosterol exhibits anti-tumour and immunomodulatory activity. A DNase has been characterized.

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2005 Royal Pharmaceutical Society of Great Britain

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