Aims, design, and measurement protocol : Medicine & Science in Sports & Exercise (original) (raw)

BASIC SCIENCES/REGULATORY PHYSIOLOGY: the heritage family study: PDF Only

BOUCHARD, CLAUDE; LEON, ARTHUR S.; RAO, D. C.; SKINNER, JAMES S.; WlLMORE, JACK H.; GAGNON, JACQUES

Physical Activity Sciences Laboratory, Laval University, Québec, G1K 7P4, CANADA

School of Kinesiology and Leisure Studies, University of Minnesota, Minneapolis, MN 55455

Division of Biostatistics and Departments of Genetics and Psychiatry, Washington University Medical School, St. Louis, MO 63110

Exercise and Sport Research Institute, Arizona State University, Tempe, AZ 85287

Department of Kinesiology and Health Education, The University of Texas at Austin, Texas, TX 78712

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Abstract

BOUCHARD, C, A. S. LEON, D. C. RAO, J. S. SKINNER, J. H. WlLMORE, and J. GAGNON. Aims, design, and measurement protocol, Med. Sci. Sports Exerc., Vol 27, No. 5, pp. 721–729, 1995. The HERITAGE family study (_HE_alth, _RI_sk factors, exercise _T_raining _A_nd _GE_netics) will document the role of the genotype in the cardiovascular, metabolic, and hormonal responses to aerobic exercise training. A consortium of five universities in the United States and Canada are involved in carrying out the study. A total of 90 Caucasian families and 40 African-American families with both parents and three or more biological adult offspring are being recruited, tested, exercise-trained in the laboratory with the same program for 20 wk, and re-tested. Oxygen uptake, respiratory exchange ratio, blood pressure, heart rale, cardiac output, blood lactatc, glucose, and free-fatty acids are measured during exercise, and maximal oxygen uptake is determined before and after training. Plasma lipids, lipoproteins and apoproteins, glucose and insulin response to an intravenous glucose load, plasma sex steroids and glucocorticoids, and body fat and fat distribution are assessed. Dietary and activity habits and other life style components are assessed by questionnaires, prior to, during, and after training. A variety of genetic analyses will be undertaken, including heritability studies and major gene effects, for each phenotype and its response to regular exercise. Cell lines arc established, and DNA sequence variation at a variety of molecular markers will be determined for association and linkage studies.