Skeletal Muscle Remodeling: Interconnections Between Stem... : Exercise and Sport Sciences Reviews (original) (raw)

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Skeletal Muscle Remodeling: Interconnections Between Stem Cells and Protein Turnover

1Department of Kinesiology and Community Health, Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, IL; and 2School of Human Kinetics, Brain and Mind Institute, Centre for Neuromuscular Disease, and Regenerative Medicine Program, University of Ottawa, Ottawa, ON, Canada

Address for correspondence: Nicholas A. Burd, Ph.D., Department of Kinesiology and Community Health, Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, S Goodwin Ave, Urbana, IL 61801 (E-mail: [email protected]).

Accepted for publication: February 27, 2017.

Editor: Benjamin F. Miller, Ph.D., FACSM.

Nutrition and exercise are important components of a healthy lifestyle to improve rates of hypertrophic and nonhypertrophic skeletal muscle remodeling. We provide evidence to support the hypothesis that muscle stem cells and protein turnover are collaborative, not separate, mechanisms supporting muscle remodeling by facilitating protein, nuclear, and cellular turnover in response to the ingestion of protein dense foods and exercise.