Cracking the epitranscriptome (original) (raw)

1. Schraga Schwartz
2. Department of Molecular Genetics, Weizmann Institute, Rehovot 76100, Israel
3. Corresponding author: schwartz{at}weizmann.ac.il

Abstract

Over 100 distinct chemical modifications can be catalyzed on RNA post-synthesis, potentially serving as a post-transcriptional regulatory layer of gene expression. This review focuses on recent advances, knowledge gaps, and challenges pertaining to_N_6-methyladenosine (m6A), an abundant modification of mRNA for which substantial progress has been made in recent years. The discussed aspects are also very relevant for a wide range of additional modifications on mRNA collectively coined the epitranscriptome.

• _N_6-methyladenosine
• epitranscriptome
• review

Footnotes

• Article and publication date are at http://www.rnajournal.org/cgi/doi/10.1261/rna.054502.115.

• © 2016 Schwartz; Published by Cold Spring Harbor Laboratory Press for the RNA Society

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