MyD88 but Not TLR2, 4 or 9 Is Essential for IL-12 Induction by Lactic Acid Bacteria (original) (raw)

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Central Laboratories for Frontier Technology, Kirin Holdings Company Ltd

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Central Laboratories for Frontier Technology, Kirin Holdings Company Ltd

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Central Laboratories for Frontier Technology, Kirin Holdings Company Ltd

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Central Laboratories for Frontier Technology, Kirin Holdings Company Ltd

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Laboratory for Host Defense, RIKEN Research Center for Allergy and Immunology

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Department of Veterinary Microbiology, School of Veterinary Medicine, Azabu University

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Central Laboratories for Frontier Technology, Kirin Holdings Company Ltd

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Published:

23 December 2007

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Shintaro ICHIKAWA, Rei FUJII, Daisuke FUJIWARA, Yutaka KOMIYAMA, Tsuneyasu KAISHO, Masahiro SAKAGUCHI, Yutaka KONISHI, MyD88 but Not TLR2, 4 or 9 Is Essential for IL-12 Induction by Lactic Acid Bacteria, Bioscience, Biotechnology, and Biochemistry, Volume 71, Issue 12, 23 December 2007, Pages 3026–3032, https://doi.org/10.1271/bbb.70414
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Abstract

Although lactic acid bacteria (LAB) affect the immune system, for example, having an anti-allergic effect, little is known about the actual mechanisms of immune modulation. Toll-like receptors (TLRs) recognize conserved microbial molecular patterns, and are presumed to be involved in the recognition of LAB. However, there are few detailed reports examining the relationships between TLR and LAB. We measured here production of IL-12, a cytokine considered to play an important role in anti-allergic effects, induced by Lactobacillus paracasei strain KW3110 and other typical LAB by cells from TLR2-, TLR4-, TLR9- and myeloid differentiation factor 88 (MyD88)-deficient mice. Unexpectedly, similar cytokine production from wild-type and TLR2-, 4- and 9-deficient mice was observed. In contrast, cells from MyD88-deficient mice failed to respond to stimulation with LAB. It is therefore concluded that although LAB, including strain KW3110, are not likely to be recognized by TLR2, 4 or 9, MyD88 is essential for the response to these bacteria.

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© Japan Society for Bioscience, Biotechnology, and Agrochemistry 2007

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