Casein Hydrolysate Containing the Antihypertensive Tripeptides Val-Pro-Pro and Ile-Pro-Pro Improves Vascular Endothelial Function Independent of Blood Pressure–Lowering Effects: Contribution of the Inhibitory Action of Angiotensin-Converting Enzyme (original) (raw)

• Lteif AA, Han K, Mather KJ : Obesity, insulin resistance, and the metabolic syndrome: determinants of endothelial dysfunction in whites and blacks. Circulation 2005; 112: 32–38.
  Article CAS Google Scholar
• Minamino T, Kitakaze M : Cellular mechanisms for the treatment of chronic heart failure: the nitric oxide- and adenosine-dependent pathways. Expert Opin Emerg Drugs 2002; 7: 99–110.
  Article CAS Google Scholar
• The SOLVD Investigators : Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med 1991; 325: 293–302.
• On YK, Kim CH, Oh BH, Lee MM, Park YB : Effects of angiotensin converting enzyme inhibitor and calcium antagonist on endothelial function in patients with essential hypertension. Hypertens Res 2002; 25: 365–371.
  Article CAS Google Scholar
• Hornig B, Kohler C, Drexler H : Role of bradykinin in mediating vascular effects of angiotensin-converting enzyme inhibitors in humans. Circulation 1997; 95: 1115–1118.
  Article CAS Google Scholar
• Kajimoto O, Seki E, Osajima K, et al: Hypotensive effects of food containing peptide derived from sardine muscle hydrolyzate, in subjects with high-normal, or hypertension. J Nutr Food 2003; 6: 65–82.
  Google Scholar
• Fujita H, Yasumoto R, Hasegawa M, Ohshima K : Human volunteers study on antihypertensive effect of “Katsuobushi oligo peptide” II: a placebo-controlled study on the effect of “Pepide soup” on blood pressure in borderline and hypertensive subjects. Jpn Pharmacol Ther 1997; 25: 2161–2165.
  Google Scholar
• Nakamura Y, Yamamoto N, Sakai K, Okubo A, Yamazaki S, Takano T : Purification and characterization of angiotensin I–converting enzyme inhibitors from sour milk. J Dairy Sci 1995; 78: 777–783.
  Article CAS Google Scholar
• Mizuno S, Nishimura S, Matsuura K, Gotou T, Yamamoto N : Release of short and proline-rich antihypertensive peptides from casein hydrolysate with an Aspergillus oryzae protease. J Dairy Sci 2004; 87: 3083–3188.
  Article Google Scholar
• Hata Y, Yamamoto M, Ohni M, Nakajima K, Nakamura Y, Takano T : A placebo-controlled study of sour milk on blood pressure in hypertensive subjects. Am J Clin Nutr 1996; 64: 767–771.
  Article CAS Google Scholar
• Higashi Y, Sasaki S, Kurisu S, et al: Regular aerobic exercise augments endothelium-dependent vascular relaxation in normotensive as well as hypertensive subjects. Role of endothelium-derived nitric oxide. Circulation 1999; 100: 1194–1202.
  Article CAS Google Scholar
• Ross R : Atherosclerosis—an inflammatory disease. N Engl J Med 1999; 340: 115–126.
  Article CAS Google Scholar
• Furumoto T, Saito N, Dong J, Mikami T, Fujii S, Kitabatake A : Association of cardiovascular risk factors and endothelial dysfunction in Japanese hypertensive patients: implications for early atherosclerosis. Hypertens Res 2002; 25: 455–460.
  Article Google Scholar
• Perticone F, Ceravolo R, Pujia A, et al: Prognostic significance of endothelial dysfunction in hypertensive patients. Circulation 2001; 104: 191–196.
  Article CAS Google Scholar
• Okura Y, Takao M, Zhang B, Nakashima Y, Saku K : Cardiovascular risk factor profiles and endothelial function in coronary artery disease patients treated with statins. Hypertens Res 2004; 27: 723–729.
  Article CAS Google Scholar
• Butler R, Morris AD, Struthers AD : Cigarette smoking in men and vascular responsiveness. Br J Clin Phamacol 2001; 52: 145–149.
  Article CAS Google Scholar
• Vigili de Kreutzenberg S, Kiwanuka E, Tiengo A, Avogaro A : Visceral obesity is characterized by impaired nitric oxide–independent vasodilatation. Eur Heart J 2003; 24: 1210–1215.
  Article CAS Google Scholar
• Taddei S, Virdis A, Mattei P, et al: Aging and endothelial function in normotensive subjects and patient with essential hypertension. Circulation 1995; 91: 1981–1987.
  Article CAS Google Scholar
• Taddei S, Virdis A, Ghiadoni L, et al: Menopause is associated with endothelial dysfunction in women. Hypertension 1996; 28: 576–582.
  Article CAS Google Scholar
• Johnstone MT, Creager SJ, Scales KM, Cusco JA, Lee BK, Creager MA : Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus. Circulation 1993; 88: 2510–2516.
  Article CAS Google Scholar
• Casino PR, Kilcoyne CM, Cannon RO 3rd, Quyyumi AA, Panza JA : Impaired endothelium-dependent vascular relaxation in patients with hypercholesterolemia extends beyond the muscarinic receptor. Am J Cardiol 1995; 75: 40–44.
  Article CAS Google Scholar
• O'Driscoll G, Green D, Taylor RR : Simvastatin: an HMG-coenzyme A reductase inhibitor, improves endothelial function within 1 month. Circulation 1997; 95: 1126–1131.
  Article CAS Google Scholar
• Sanada M, Higashi Y, Nakagawa K, et al: Hormone replacement effects on endothelial function measured in the forearm resistance artery in normocholesterolemic and hypercholesterolemic postmenopausal women. J Clin Endocrinol Metab 2002; 87: 4634–4641.
  Article CAS Google Scholar
• Kitakaze M, Minamino T, Node K, et al: Beneficial effects of inhibition of angiotensin-converting enzyme on ischemic myocardium during coronary hypoperfusion in dogs. Circulation 1995; 92: 950–961.
  Article CAS Google Scholar
• Gokce N, Holbrook M, Hunter LM, et al: Acute effects of vasoactive drug treatment on brachial artery reactivity. J Am Coll Cardiol 2002; 40: 761–765.
  Article CAS Google Scholar
• Dahlof B, Pennert K, Hansson L : Reversal of left ventricular hypertrophy in hypertensive patients. A metaanalysis of 109 treatment studies. Am J Hypertens 1992; 5: 95–110.
  Article CAS Google Scholar
• Benjamin N, Calver A, Collier J, Robinson B, Vallance P, Webb D : Measuring forearm blood flow and interpreting the responses to drug and mediators. Hypertension 1995; 25: 918–923.
  Article CAS Google Scholar
• Higashi Y, Sasaki S, Nakagawa K, Matsuura H, Kajiyama G, Oshima T : A noninvasive measurement of reactive hyperemia that can be used to assess resistance artery endothelial function in humans. Am J Cardiol 2001; 87: 121–125.
  Article CAS Google Scholar
• Higashi Y, Sasaki S, Nakagawa K, et al: A comparison of angiotenisn-converting enzyme inhibitors, calcium antagonists, beta-blockers and diuretic agents on reactive hyperemia in patients with essential hypertension: a multicenter study. J Am Coll Cardiol 2000; 35: 284–291.
  Article CAS Google Scholar
• Tagawa T, Imaizumi T, Endo T, Shiramoto M, Harasawa Y, Takeshita A : Role of nitric oxide in reactive hyperemia in human forearm vessels. Circulation 1994; 90: 2285–2290.
  Article CAS Google Scholar
• Togashi N, Ura N, Higashimura K, Murakami H, Shimamoto K : The contribution of skeletal muscle tumor necrosis factor-alpha to insulin resistance and hypertension in fructose-fed rats. J Hypertens 2000; 18: 1605–1610.
  Article CAS Google Scholar