Do Eicosapentaenoic Acid Supplements Attenuate Age-Related Increases in Arterial Stiffness in Patients with Dyslipidemia?: A Preliminary Study (original) (raw)

Hypertension Research volume 28, pages 651–655 (2005)Cite this article

Abstract

The present study was conducted to examine the effect of eicosapentaenoic acid supplements on pulse wave velocity (PWV) in patients with dyslipidemia as a prospective open-labeled study. Eicosapentaenoic acid supplements (1,800 mg/day) were prescribed to 40 patients, and diet therapy in consultation with a nutritionist was conducted in 44 patients as a control group. These interventions were continued for 12 months, and PWV and blood examinations were performed at the start and end of these interventions. PWV increased in the control group but not in the eicosapentaenoic acid group. After adjustment for age, gender, the initial PWV, and the changes in mean blood pressure during the study period, a general linear model univariate analysis post hoc comparison demonstrated that the change in PWV during the period of study was significantly larger in the control group (42±20 cm/s) than in the eicosapentaenoic acid group (-9±19 cm/s) (p<0.05). Thus, this preliminary study suggested that eicosapentaenoic acid supplements attenuate age-related increases in arterial stiffness in patients with dyslipidemia. A further study with a larger number of subjects is proposed to confirm this beneficial effect of eicosapentaenoic acid supplements on arterial stiffness.

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References

  1. Daviglus ML, Stamler J, Orencia AJ, et al: Fish consumption and the 30-year risk of fatal myocardial infarction. N Engl J Med 1997; 336: 1046–1053.
    Article CAS Google Scholar
  2. Hino A, Adachi H, Toyomasu K, et al: Very long chain _N_-3 fatty acids intake and carotid atherosclerosis: an epidemiological study evaluated by ultrasonography. Atherosclerosis 2004; 176: 145–149.
    Article CAS Google Scholar
  3. von Schacky C, Angerer P, Kothny W, Theisen K, Mudra H : The effect of dietary omega-3 fatty acids on coronary atherosclerosis. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 1999; 130: 554–562.
    Article CAS Google Scholar
  4. Marchioli R, Barzi F, Bomba E, et al, GISSI-Prevenzione Investigators : Early protection against sudden death by _n_-3 polyunsaturated fatty acids after myocardial infarction: time-course analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-Prevenzione. Circulation 2002; 105: 1897–1903.
    Article CAS Google Scholar
  5. Yamashina A, Tomiyama H, Arai T, et al: Brachial-ankle pulse wave velocity as a marker of atherosclerotic vascular damage and cardiovascular risk. Hypertens Res 2003; 26: 615–622.
    Article Google Scholar
  6. Cruickshank K, Riste L, Anderson SG, Wright JS, Dunn G, Gosling RG : Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance: an integrated index of vascular function? Circulation 2002; 106: 2085–2090.
    Article Google Scholar
  7. Guerin AP, Blacher J, Pannier B, Marchais SJ, Safar ME, London GM : Impact of aortic stiffness attenuation on survival of patients in end-stage renal failure. Circulation 2001; 103: 987–992.
    Article CAS Google Scholar
  8. Japan Atherosclerosis Society : Japan Atherosclerosis Society Guidelines for Diagnosis and Treatment of Atherosclerotic Cardiovascular Diseases. Tokyo, Japan Atherosclerosis Society, 2002, pp 24–26.
  9. Yamashina A, Tomiyama H, Takeda K, et al: Validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity measurement. Hypertens Res 2002; 25: 359–364.
    Article Google Scholar
  10. Tomiyama H, Yamashina A, Arai T, et al: Influences of age and gender on results of noninvasive brachial-ankle pulse wave velocity measurement—a survey of 12517 subjects. Atherosclerosis 2003; 166: 303–309.
    Article CAS Google Scholar
  11. Browner WS, Newman TB, Cummings SR, Hulley SB : Sample size, in Hulley SB, Cummings SR, Browner WS, Grady D, Hearst N, Newman TB ( eds), Kihara M, Kihara M ( translated to Japanese): Designing Clinical Research, 2nd ed. Tokyo, Medical Science International, 2004, pp 65–91.
    Google Scholar
  12. Nestel P, Shige H, Pomeroy S, Cehun M, Abbey M, Raederstorff D : The _n_-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid increase systemic arterial compliance in humans. Am J Clin Nutr 2002; 76: 326–330.
    Article CAS Google Scholar
  13. von Schacky C : The role of omega-3 fatty acids in cardiovascular disease. Curr Atheroscler Rep 2003; 5: 139–145.
    Article Google Scholar
  14. Park Y, Harris W : EPA, but not DHA, decreases mean platelet volume in normal subjects. Lipids 2002; 37: 941–946.
    Article CAS Google Scholar
  15. Tsuruta K, Ogawa H, Yasue H, et al: Effect of purified eicosapentaenoate ethyl ester on fibrinolytic capacity in patients with stable coronary artery disease and lower extremity ischaemia. Coron Artery Dis 1996; 7: 837–842.
    Article CAS Google Scholar
  16. Khan F, Elherik K, Bolton-Smith C, et al: The effects of dietary fatty acid supplementation on endothelial function and vascular tone in healthy subjects. Cardiovasc Res 2003; 59: 955–962.
    Article CAS Google Scholar
  17. Oliver JJ, Webb DJ : Noninvasive assessment of arterial stiffness and risk of atherosclerotic events. Arterioscler Thromb Vasc Biol 2003; 23: 554–566.
    Article CAS Google Scholar
  18. Yamashina A, Tomiyama H, Arai T, et al: Nomogram of the relation of brachial-ankle pulse wave velocity with blood pressure. Hypertens Res 2003; 26: 801–806.
    Article Google Scholar
  19. Takami T, Shigemasa M : Efficacy of various antihypertensive agents as evaluated by indices of vascular stiffness in elderly hypertensive patients. Hypertens Res 2003; 26: 609–614.
    Article CAS Google Scholar
  20. Satoh N, Ogawa Y, Usui T, et al: Antiatherogenic effect of pioglitazone in type 2 diabetic patients irrespective of the responsiveness to its antidiabetic effect. Diabetes Care 2003; 26: 2493–2499.
    Article CAS Google Scholar
  21. Berstad P, Seljeflot I, Veierod MB, Hjerkinn EM, Arnesen H, Pedersen JI : Supplementation with fish oil affects the association between very long-chain _n_-3 polyunsaturated fatty acids in serum non-esterified fatty acids and soluble vascular cell adhesion molecule-1. Clin Sci (Lond) 2003; 105: 13–20.
    Article CAS Google Scholar
  22. Adan Y, Shibata K, Sato M, Ikeda I, Imaizumi K : Effects of docosahexaenoic and eicosapentaenoic acid on lipid metabolism, eicosanoid production, platelet aggregation and atherosclerosis in hypercholesterolemic rats. Biosci Biotechnol Biochem 1999; 63: 111–119.
    Article CAS Google Scholar

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Authors and Affiliations

  1. Second Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan
    Hirofumi Tomiyama, Kenji Takazawa & Akira Yamashina
  2. Tokyo Medical University Kasumigaura Hospital, Ibaraki, Japan
    Shin-ichi Osa & Ken-ichi Hirose
  3. Kosei-cho Hospital, Tokyo, Japan
    Akio Hirai
  4. Iketani Clinic, Tokyo, Japan
    Toshiro Iketani
  5. St. Luke's International Hospital Tokyo, Tokyo, Japan
    Masami Monden
  6. Sanoyama Clinic, Tokyo, Japan
    Kyo Sanoyama

Authors

  1. Hirofumi Tomiyama
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  2. Kenji Takazawa
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  3. Shin-ichi Osa
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  4. Ken-ichi Hirose
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  5. Akio Hirai
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  6. Toshiro Iketani
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  7. Masami Monden
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  8. Kyo Sanoyama
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  9. Akira Yamashina
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Correspondence toAkira Yamashina.

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Tomiyama, H., Takazawa, K., Osa, Si. et al. Do Eicosapentaenoic Acid Supplements Attenuate Age-Related Increases in Arterial Stiffness in Patients with Dyslipidemia?: A Preliminary Study.Hypertens Res 28, 651–655 (2005). https://doi.org/10.1291/hypres.28.651

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