Detection of Severe Acute Respiratory Syndrome–Associated Coronavirus in Pneumocytes of the Lung (original) (raw)
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1Institute of Biomedical Sciences, National Taiwan University Hospital, Taipei
5Medical Research, China Medical University Hospital, Taichung, Taiwan
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2Department of Pathology, National Taiwan University Hospital, Taipei
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3Departments of Pathology, China Medical University Hospital, Taichung, Taiwan
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3Departments of Pathology, China Medical University Hospital, Taichung, Taiwan
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4Graduate Institute of Veterinary Microbiology, National Chung Hsing University, Taichung
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Supported by grant DMR-92-085 from the Department of Medical Research, China Medical University Hospital, Taiwan.
Published:
04 January 2004
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Kuan-Chih Chow, Cheng-Hsiang Hsiao, Tze-Yi Lin, Chi-Long Chen, Shiow-Her Chiou, Detection of Severe Acute Respiratory Syndrome–Associated Coronavirus in Pneumocytes of the Lung, American Journal of Clinical Pathology, Volume 121, Issue 4, April 2004, Pages 574–580, https://doi.org/10.1309/C0EDU0RAQBTXBHCE
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Abstract
Previous reports have indicated that patients with severe acute respiratory syndrome (SARS)–associated coronavirus infection could develop atypical pneumonia with fulminant pulmonary edema. However, the target cells of SARS viral infection have not been characterized in detail. We report the pathologic findings of the lung in 3 cases of SARS. Chest radiographs at 2 to 3 weeks of infection revealed an atypical pneumonia with pulmonary consolidation, a clinical characteristic of SARS infection. The presence of the SARS virus was determined by nested reverse transcription–polymerase chain reaction (RT-PCR), and the infected cells were identified by in situ hybridization in open-lung biopsy and postmortem necropsy specimens. Expression of SARS virus–encoded RNA was detected in all 3 cases by RT-PCR, and the SARS viral signal was localized in pneumocytes by using in situ hybridization.
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Author notes
Supported by grant DMR-92-085 from the Department of Medical Research, China Medical University Hospital, Taiwan.
© American Society of Clinical Pathologists
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