Calciotropic Hormones and Bone Markers in the Elderly* (original) (raw)
Journal Article
,
Bone Metabolism Unit, Creighton University School of Medicine, Omaha, Nebraska, U.S.A.
Search for other works by this author on:
,
Bone Metabolism Unit, Creighton University School of Medicine, Omaha, Nebraska, U.S.A.
Search for other works by this author on:
,
Henry Ford Health System, Detroit, Michigan, U.S.A.
Search for other works by this author on:
,
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, U.S.A.
Search for other works by this author on:
,
University of Connecticut Health Center, Farmington, Connecticut, U.S.A.
Search for other works by this author on:
National Institute on Aging, National Institutes of Health, Bethesda, Maryland, U.S.A.
Search for other works by this author on:
Revision received:
06 November 1997
Accepted:
06 November 1997
Published:
04 December 2009
Cite
J. Christopher Gallagher, H. Karimi Kinyamu, Sarah E. Fowler, Bess Dawson‐Hughes, Gail P. Dalsky, Sherry S. Sherman, Calciotropic Hormones and Bone Markers in the Elderly, Journal of Bone and Mineral Research, Volume 13, Issue 3, 1 March 1998, Pages 475–482, https://doi.org/10.1359/jbmr.1998.13.3.475
Close
Navbar Search Filter Mobile Enter search term Search
Abstract
There is a lack of substantial data on changes in calciotropic hormones and bone markers in elderly subjects living in North America. Parathyroid hormone (PTH), serum 25‐hydroxyvitamin D (25(OH)D) and bone markers (serum osteocalcin and urine N‐telopeptide), were measured in 735 Caucasian subjects (235 men and 500 women) aged 65–87 years. There was a significant increase in serum osteocalcin and urine N‐telopeptide with age in men, and a significant increase in serum osteocalcin with age in women. Serum PTH and 25(OH)D showed no significant change with age in men or women. After adjusting for age, calcium intake, serum creatinine, season, and weight, mean serum PTH (p = 0.01), serum osteocalcin (p = 0.0001) and 24 h urine N‐telopeptide (p = 0.0001) were higher in women than men, and mean serum 25(OH)D (p = 0.0001) and 24 h urine calcium (p = 0.0001) were higher in men than women. Serum PTH was correlated with serum osteocalcin in men and women, r = 0.24, r = 0.17, p < 0.001, but not with urine N‐telopeptide. Serum PTH was inversely correlated with serum 25(OH)D (r = −0.25, r = −0.34, p < 0.001), and positively correlated with serum creatinine (r = 0.14, r = 0.17, p < 0.01) in men and women. The prevalence of serum 25(OH)D levels below 12 ng/ml was only 3.3% in females and 0.4% in men. Thus vitamin D deficiency was very uncommon in the U.S.A. compared with Europe. Although mean serum PTH was increased in the elderly, only 4–6% had PTH levels above the normal range. In summary, the increase in serum PTH in the elderly can be explained more by changes in vitamin D status than by declining renal function. These data also show significantly higher (p = 0.001) bone remodeling markers in women.
Copyright © 1998 ASBMR
You do not currently have access to this article.
Personal account
- Sign in with email/username & password
- Get email alerts
- Save searches
- Purchase content
- Activate your purchase/trial code
- Add your ORCID iD
Get help with access
Institutional access
Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:
IP based access
Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.
Sign in through your institution
Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.
- Click Sign in through your institution.
- Select your institution from the list provided, which will take you to your institution's website to sign in.
- When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.
Sign in with a library card
Enter your library card number to sign in. If you cannot sign in, please contact your librarian.
Society Members
Society member access to a journal is achieved in one of the following ways:
Sign in through society site
Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:
- Click Sign in through society site.
- When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If you do not have a society account or have forgotten your username or password, please contact your society.
Sign in using a personal account
Some societies use Oxford Academic personal accounts to provide access to their members. See below.
Personal account
A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.
Some societies use Oxford Academic personal accounts to provide access to their members.
Viewing your signed in accounts
Click the account icon in the top right to:
- View your signed in personal account and access account management features.
- View the institutional accounts that are providing access.
Signed in but can't access content
Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.
Institutional account management
For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.
Purchase
Short-term Access
To purchase short-term access, please sign in to your personal account above.
Don't already have a personal account? Register
Calciotropic Hormones and Bone Markers in the Elderly* - 24 Hours access
EUR €46.00
GBP £40.00
USD $49.00
Rental
This article is also available for rental through DeepDyve.
Citations
Views
Altmetric
Metrics
Total Views 30
23 Pageviews
7 PDF Downloads
Since 2/1/2024
| Month: | Total Views: |
|---|---|
| February 2024 | 15 |
| March 2024 | 5 |
| April 2024 | 7 |
| May 2024 | 1 |
| October 2024 | 2 |
Citations
98 Web of Science
×
Email alerts
Email alerts
Citing articles via
More from Oxford Academic