Reduced Expression of Interleukin‐11 in Bone Marrow Stromal Cells of Senescence‐Accelerated Mice (SAMP6): Relationship to Osteopenia with Enhanced Adipogenesis (original) (raw)
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Department of Orthopedic Surgery, University of Tokyo School of Medicine, Tokyo, Japan
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Fourth Department of Internal Medicine, University of Tokyo School of Medicine, Tokyo, Japan
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Fourth Department of Internal Medicine, University of Tokyo School of Medicine, Tokyo, Japan
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Fourth Department of Internal Medicine, University of Tokyo School of Medicine, Tokyo, Japan
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Kureha Biomedical Research Laboratories, Tokyo, Japan
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Kureha Biomedical Research Laboratories, Tokyo, Japan
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Fourth Department of Internal Medicine, University of Tokyo School of Medicine, Tokyo, Japan
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Department of Orthopedic Surgery, University of Tokyo School of Medicine, Tokyo, Japan
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First Department of Internal Medicine, University of Tokushima School of Medicine, Tokushima, Japan
Toshio Matsumoto, M.D., First Department of Internal Medicine, University of Tokushima School of Medicine, 3–18–15 Kuramotocho, Tokushima 770, Japan
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Received:
18 November 1997
Revision received:
24 April 1998
Published:
04 December 2009
Cite
Yoshiaki Kodama, Yasuhiro Takeuchi, Miyuki Suzawa, Seiji Fukumoto, Hisashi Murayama, Hideyuki Yamato, Toshiro Fujita, Takahide Kurokawa, Toshio Matsumoto, Reduced Expression of Interleukin‐11 in Bone Marrow Stromal Cells of Senescence‐Accelerated Mice (SAMP6): Relationship to Osteopenia with Enhanced Adipogenesis, Journal of Bone and Mineral Research, Volume 13, Issue 9, 1 September 1998, Pages 1370–1377, https://doi.org/10.1359/jbmr.1998.13.9.1370
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Abstract
Aging is associated with an increase in bone marrow adipose tissue and a reduction in bone turnover. The P6 strain of senescence‐accelerated mice (SAM) exhibit an early decrease in bone mass with a reduction in bone remodeling. In the bone marrow, suppressed osteoblastogenesis and osteoclastogenesis with enhanced adipogenesis are observed. The present study was undertaken to clarify the mechanism of age‐related changes in bone turnover using bone marrow cells from SAMP6 mice. Because interleukin (IL)‐11 has been shown to potently inhibit adipogenesis and to stimulate osteoclast formation, the effect of IL‐11 on the differentiation of bone marrow cells was examined. The impaired formation of both osteoblasts and osteoclasts was restored and the enhanced formation of adipocytes was suppressed by the addition of 10 pM recombinant human IL‐11. Other cytokines that activate gp130 as a common signal transducer, IL‐6 and leukemia inhibitory factor, did not have such effects. Sequence analysis of the entire coding region of IL‐11 cDNA obtained from SAMP6 stromal cells revealed no mutations. Constitutively secreted IL‐11 protein into culture media, and its mRNA expression stimulated by transforming growth factor β were reduced in stromal cells from SAMP6 compared with those in control mice. These results demonstrate that the expression of IL‐11 is reduced in bone marrow cells of SAMP6 and suggest that the reduction in IL‐11 actions is involved in the impairment of both osteoblastogenesis and osteoclastogenesis in these mice. There is a possibility that alterations in IL‐11 actions may be associated with the age‐related impairment in bone metabolism.
Copyright © 1998 ASBMR
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