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548.14 l 212.58 546.61 l 215.80 545.04 l 219.03 542.69 l 222.26 541.35 l 225.49 540.05 l 228.71 538.45 l 231.94 536.74 l 235.17 535.42 l 238.39 534.07 l 241.62 532.43 l 244.85 530.85 l 248.07 529.08 l 251.30 527.76 l 254.53 526.17 l 257.75 524.71 l 260.98 523.22 l 264.21 521.92 l 267.44 520.51 l 270.66 519.29 l 273.89 517.96 l 277.12 516.47 l 280.34 515.49 l 283.57 514.34 l 286.80 513.22 l 290.02 512.26 l 293.25 511.07 l 296.48 509.91 l 299.71 508.72 l 302.93 507.74 l 306.16 506.97 l 309.39 505.98 l 312.61 505.14 l S 0.000 1.000 0.000 RG 57.68 617.42 m 60.91 612.56 l 64.14 610.94 l 67.36 601.62 l 70.59 604.78 l 73.82 604.45 l 77.04 606.31 l 80.27 605.87 l 83.50 602.83 l 86.73 603.28 l 89.95 602.83 l 93.18 602.46 l 96.41 601.79 l 99.63 600.24 l 102.86 599.79 l 106.09 598.26 l 109.31 597.16 l 112.54 596.69 l 115.77 595.54 l 119.00 593.80 l 122.22 592.88 l 125.45 592.26 l 128.68 589.86 l 131.90 588.24 l 135.13 586.37 l 138.36 584.46 l 141.58 582.86 l 144.81 582.20 l 148.04 580.62 l 151.26 579.77 l 154.49 578.51 l 157.72 576.45 l 160.95 574.94 l 164.17 573.23 l 167.40 572.03 l 170.63 569.97 l 173.85 567.76 l 177.08 565.54 l 180.31 563.56 l 183.53 561.55 l 186.76 560.10 l 189.99 557.81 l 193.22 555.96 l 196.44 554.30 l 199.67 552.71 l 202.90 551.09 l 206.12 549.23 l 209.35 547.45 l 212.58 546.02 l 215.80 543.90 l 219.03 542.13 l 222.26 540.25 l 225.49 538.61 l 228.71 536.86 l 231.94 535.35 l 235.17 533.80 l 238.39 532.06 l 241.62 530.45 l 244.85 528.74 l 248.07 527.40 l 251.30 526.19 l 254.53 524.55 l 257.75 523.57 l 260.98 522.17 l 264.21 520.74 l S 1.000 0.000 0.000 RG 57.68 627.15 m 60.91 614.99 l 64.14 614.18 l 67.36 610.13 l 70.59 612.56 l 73.82 609.32 l 77.04 612.56 l 80.27 609.52 l 83.50 605.27 l 86.73 605.04 l 89.95 604.86 l 93.18 604.70 l 96.41 603.88 l 99.63 602.51 l 102.86 600.10 l 106.09 600.83 l 109.31 599.32 l 112.54 599.25 l 115.77 596.51 l 119.00 595.19 l 122.22 593.33 l 125.45 593.11 l 128.68 591.48 l 131.90 589.21 l 135.13 587.12 l 138.36 585.90 l 141.58 584.07 l 144.81 583.55 l 148.04 581.76 l 151.26 580.24 l 154.49 578.67 l 157.72 576.60 l 160.95 574.79 l 164.17 573.09 l 167.40 572.16 l 170.63 570.23 l 173.85 568.79 l 177.08 566.17 l 180.31 564.29 l 183.53 562.38 l 186.76 560.22 l 189.99 558.04 l 193.22 556.63 l 196.44 554.74 l 199.67 552.82 l 202.90 550.37 l 206.12 548.93 l 209.35 546.95 l 212.58 545.05 l 215.80 543.61 l 219.03 541.47 l S 0.000 0.000 0.000 RG 0.75 w [] 0 d 344.88 627.15 92.02 -57.02 re S 3.00 w [] 0 d 355.75 608.14 m 370.00 608.14 l S 0.000 0.000 1.000 RG 355.75 598.64 m 370.00 598.64 l S 0.000 1.000 0.000 RG 355.75 589.14 m 370.00 589.14 l S 1.000 0.000 0.000 RG 355.75 579.63 m 370.00 579.63 l S BT 0.000 0.000 0.000 rg /F2 1 Tf 11.00 0.00 -0.00 11.00 329.75 617.65 Tm ( Noise introduced ) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 377.13 604.20 Tm (None ) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 377.13 594.69 Tm (10%) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 377.13 585.19 Tm (30%) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 377.13 575.68 Tm (50%) Tj ET Q q 516.11 398.55 418.22 262.65 re W n Q q 516.11 398.55 418.22 262.65 re W n 0.000 0.000 0.000 RG 1.50 w [] 0 d 1 J 1 j 10.00 M 534.82 627.15 m 538.05 619.86 l 541.28 620.67 l 544.50 611.34 l 547.73 611.59 l 550.96 610.94 l 554.18 610.48 l 557.41 610.74 l 560.64 608.78 l 563.87 606.72 l 567.09 606.81 l 570.32 605.27 l 573.55 603.58 l 576.77 603.18 l 580.00 601.86 l 583.23 600.10 l 586.45 601.12 l 589.68 599.59 l 592.91 598.74 l 596.14 596.27 l 599.36 595.19 l 602.59 593.11 l 605.82 592.05 l 609.04 590.88 l 612.27 589.41 l 615.50 588.05 l 618.72 586.80 l 621.95 585.98 l 625.18 584.55 l 628.41 582.73 l 631.63 581.02 l 634.86 580.03 l 638.09 578.37 l 641.31 575.51 l 644.54 573.65 l 647.77 572.16 l 650.99 570.63 l 654.22 569.17 l 657.45 567.66 l 660.67 565.75 l 663.90 564.40 l 667.13 562.88 l 670.36 561.55 l 673.58 559.50 l 676.81 558.41 l 680.04 556.52 l 683.26 555.13 l 686.49 553.18 l 689.72 551.32 l 692.94 549.72 l 696.17 547.81 l 699.40 546.06 l 702.63 544.56 l 705.85 542.85 l 709.08 540.93 l 712.31 539.26 l 715.53 537.64 l 718.76 536.08 l 721.99 534.90 l 725.21 533.12 l 728.44 531.55 l 731.67 530.19 l 734.90 528.49 l 738.12 527.22 l 741.35 525.54 l 744.58 524.35 l 747.80 523.05 l 751.03 521.72 l 754.26 520.36 l 757.48 519.18 l 760.71 517.96 l 763.94 516.70 l 767.16 515.55 l 770.39 514.10 l 773.62 512.95 l 776.85 511.76 l 780.07 510.61 l 783.30 509.55 l 786.53 508.51 l 789.75 507.38 l 792.98 506.28 l 796.21 505.32 l 799.43 504.27 l 802.66 503.13 l 805.89 502.12 l 809.12 501.03 l 812.34 500.58 l 815.57 499.75 l 818.80 499.05 l 822.02 498.32 l 825.25 497.54 l 828.48 496.68 l 831.70 495.83 l 834.93 494.90 l 838.16 494.29 l 841.39 493.55 l 844.61 492.77 l 847.84 492.06 l 854.29 490.72 l 857.52 490.00 l 860.75 489.25 l 863.97 488.51 l 867.20 487.83 l 870.43 487.21 l 873.65 486.56 l 876.88 486.01 l 880.11 485.34 l 883.34 484.72 l S Q q 0.000 0.000 0.000 RG 0.75 w [] 0 d 1 J 1 j 10.00 M 531.60 398.55 m 918.83 398.55 l S 531.60 398.55 m 531.60 393.80 l S 596.14 398.55 m 596.14 393.80 l S 660.67 398.55 m 660.67 393.80 l S 725.21 398.55 m 725.21 393.80 l S 789.75 398.55 m 789.75 393.80 l S 854.29 398.55 m 854.29 393.80 l S 918.83 398.55 m 918.83 393.80 l S BT 0.000 0.000 0.000 rg /F2 1 Tf 11.00 0.00 -0.00 11.00 528.54 381.45 Tm (0) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 583.90 381.45 Tm (1000) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 648.44 381.45 Tm (2000) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 712.98 381.45 Tm (3000) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 777.52 381.45 Tm (4000) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 842.06 381.45 Tm (5000) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 906.60 381.45 Tm (6000) Tj ET 516.11 408.28 m 516.11 651.47 l S 516.11 408.28 m 511.35 408.28 l S 516.11 456.92 m 511.35 456.92 l S 516.11 505.56 m 511.35 505.56 l S 516.11 554.20 m 511.35 554.20 l S 516.11 602.83 m 511.35 602.83 l S 516.11 651.47 m 511.35 651.47 l S BT /F2 1 Tf 0.00 11.00 -11.00 0.00 504.70 405.22 Tm (0) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 504.70 450.80 Tm (20) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 504.70 499.44 Tm (40) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 504.70 548.08 Tm (60) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 504.70 596.72 Tm (80) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 504.70 642.30 Tm (100) Tj ET 516.11 398.55 m 934.32 398.55 l 934.32 661.20 l 516.11 661.20 l 516.11 398.55 l S Q q 477.14 350.08 477.14 350.08 re W n BT 0.000 0.000 0.000 rg /F3 1 Tf 13.00 0.00 -0.00 13.00 713.66 676.02 Tm (mtc) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 665.16 362.44 Tm (Number of ranked peaks) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 485.69 484.03 Tm (% peaks with motif) Tj ET Q q 516.11 398.55 418.22 262.65 re W n 0.000 0.000 1.000 RG 1.50 w [] 0 d 1 J 1 j 10.00 M 534.82 622.29 m 538.05 619.86 l 541.28 620.67 l 544.50 612.56 l 547.73 613.53 l 550.96 612.56 l 554.18 611.17 l 557.41 611.34 l 560.64 608.78 l 563.87 608.18 l 567.09 606.81 l 570.32 604.86 l 573.55 604.33 l 576.77 602.14 l 580.00 601.86 l 583.23 600.71 l 586.45 600.83 l 589.68 598.51 l 592.91 598.99 l 596.14 597.00 l 599.36 594.73 l 602.59 593.77 l 605.82 592.47 l 609.04 591.08 l 612.27 589.60 l 615.50 587.87 l 618.72 586.98 l 621.95 584.94 l 625.18 583.21 l 628.41 582.24 l 631.63 580.71 l 634.86 579.12 l 638.09 577.48 l 641.31 576.37 l 644.54 574.48 l 647.77 572.97 l 650.99 571.15 l 654.22 569.30 l 657.45 567.79 l 660.67 565.99 l 663.90 564.28 l 667.13 562.30 l 670.36 561.21 l 673.58 559.28 l 676.81 557.87 l 680.04 556.42 l 683.26 554.20 l 686.49 552.17 l 689.72 550.52 l 692.94 548.75 l 696.17 547.04 l 699.40 544.75 l 702.63 543.46 l 705.85 542.31 l 709.08 540.75 l 712.31 539.17 l 715.53 537.56 l 718.76 536.00 l 721.99 534.08 l 725.21 532.31 l 728.44 530.51 l 731.67 529.09 l 734.90 527.79 l 738.12 526.46 l 741.35 525.24 l 744.58 523.61 l 747.80 521.96 l 751.03 520.51 l 754.26 519.44 l 757.48 517.93 l 760.71 516.86 l 763.94 515.62 l 767.16 514.35 l 770.39 513.05 l 773.62 511.85 l 776.85 510.74 l 780.07 509.47 l 783.30 508.30 l 786.53 507.22 l 789.75 506.10 l 792.98 505.38 l 796.21 504.43 l 799.43 503.56 l 802.66 502.55 l 805.89 501.78 l 809.12 501.03 l 812.34 500.08 l 815.57 499.15 l 818.80 498.34 l 822.02 497.45 l 825.25 496.47 l 828.48 495.57 l 831.70 494.89 l 834.93 494.07 l 838.16 493.63 l 841.39 492.94 l 844.61 492.22 l 847.84 491.36 l 854.29 489.75 l 857.52 488.94 l S 0.000 1.000 0.000 RG 534.82 627.15 m 538.05 619.86 l 541.28 620.67 l 544.50 610.13 l 547.73 611.59 l 550.96 610.94 l 554.18 611.17 l 557.41 610.74 l 560.64 607.70 l 563.87 605.49 l 567.09 604.45 l 570.32 603.96 l 573.55 604.22 l 576.77 601.86 l 580.00 600.71 l 583.23 600.54 l 586.45 599.86 l 589.68 597.97 l 592.91 595.54 l 596.14 594.50 l 599.36 593.33 l 602.59 592.89 l 605.82 591.48 l 609.04 588.63 l 612.27 587.68 l 615.50 586.26 l 618.72 584.25 l 621.95 583.21 l 625.18 582.24 l 628.41 580.40 l 631.63 579.12 l 634.86 577.78 l 638.09 576.08 l 641.31 573.93 l 644.54 571.89 l 647.77 569.71 l 650.99 567.63 l 654.22 566.17 l 657.45 564.17 l 660.67 562.86 l 663.90 561.26 l 667.13 559.74 l 670.36 557.51 l 673.58 555.82 l 676.81 553.88 l 680.04 552.02 l 683.26 549.94 l 686.49 547.74 l 689.72 546.02 l 692.94 545.04 l 696.17 542.97 l 699.40 540.98 l 702.63 538.88 l 705.85 537.75 l 709.08 535.96 l 712.31 534.06 l 715.53 533.23 l 718.76 531.61 l 721.99 529.80 l 725.21 528.28 l 728.44 526.82 l 731.67 525.71 l 734.90 524.40 l 738.12 522.99 l 741.35 521.77 l 744.58 520.44 l 747.80 519.00 l 751.03 517.82 l 754.26 516.67 l 757.48 515.56 l 760.71 514.34 l 763.94 513.15 l 767.16 512.13 l 770.39 511.00 l 773.62 509.97 l 776.85 508.65 l 780.07 507.80 l 783.30 506.60 l S 1.000 0.000 0.000 RG 534.82 627.15 m 538.05 617.42 l 541.28 617.42 l 544.50 611.34 l 547.73 612.56 l 550.96 613.37 l 554.18 613.26 l 557.41 611.95 l 560.64 605.27 l 563.87 605.93 l 567.09 604.05 l 570.32 604.70 l 573.55 603.88 l 576.77 601.54 l 580.00 602.23 l 583.23 600.83 l 586.45 599.32 l 589.68 597.71 l 592.91 595.78 l 596.14 594.73 l 599.36 593.33 l 602.59 591.63 l 605.82 590.47 l 609.04 588.83 l 612.27 586.93 l 615.50 585.54 l 618.72 584.59 l 621.95 582.87 l 625.18 582.24 l 628.41 580.55 l 631.63 579.58 l 634.86 577.34 l 638.09 575.94 l 641.31 573.93 l 644.54 572.03 l 647.77 570.50 l 650.99 569.43 l 654.22 567.04 l 657.45 565.14 l 660.67 563.21 l 663.90 560.22 l 667.13 558.27 l 670.36 555.85 l 673.58 554.41 l 676.81 551.97 l 680.04 549.95 l 683.26 548.32 l 686.49 545.66 l 689.72 543.98 l 692.94 542.08 l 696.17 539.79 l 699.40 537.95 l 702.63 536.45 l 705.85 534.83 l 709.08 533.44 l 712.31 531.75 l 715.53 530.38 l 718.76 528.56 l 721.99 526.63 l 725.21 524.85 l 728.44 523.13 l S 0.000 0.000 0.000 RG 0.75 w [] 0 d 822.02 627.15 92.02 -57.02 re S 3.00 w [] 0 d 832.89 608.14 m 847.14 608.14 l S 0.000 0.000 1.000 RG 832.89 598.64 m 847.14 598.64 l S 0.000 1.000 0.000 RG 832.89 589.14 m 847.14 589.14 l S 1.000 0.000 0.000 RG 832.89 579.63 m 847.14 579.63 l S BT 0.000 0.000 0.000 rg /F2 1 Tf 11.00 0.00 -0.00 11.00 806.89 617.65 Tm ( Noise introduced ) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 854.27 604.20 Tm (None ) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 854.27 594.69 Tm (10%) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 854.27 585.19 Tm (30%) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 854.27 575.68 Tm (50%) Tj ET Q q 38.97 48.47 418.22 262.65 re W n Q q 38.97 48.47 418.22 262.65 re W n 0.000 0.000 0.000 RG 1.50 w [] 0 d 1 J 1 j 10.00 M 57.68 199.25 m 60.91 208.98 l 64.14 223.57 l 67.36 221.14 l 70.59 220.65 l 73.82 226.00 l 77.04 229.13 l 80.27 229.65 l 83.50 228.92 l 86.73 233.30 l 89.95 234.51 l 93.18 232.92 l 96.41 231.21 l 99.63 232.32 l 102.86 232.38 l 106.09 233.30 l 109.31 233.03 l 112.54 232.78 l 115.77 233.54 l 119.00 231.21 l 122.22 229.54 l 125.45 228.64 l 128.68 228.43 l 131.90 228.04 l 135.13 226.56 l 138.36 224.47 l 141.58 223.92 l 144.81 221.89 l 148.04 220.97 l 151.26 220.43 l 154.49 219.46 l 157.72 217.67 l 160.95 216.27 l 164.17 214.53 l 167.40 213.57 l 170.63 212.53 l 173.85 210.64 l 177.08 209.10 l 180.31 207.64 l 183.53 206.25 l 186.76 204.34 l 189.99 202.30 l 193.22 201.02 l 196.44 199.79 l 199.67 198.61 l 202.90 197.18 l 206.12 195.09 l 209.35 193.29 l 212.58 191.56 l 215.80 189.81 l 219.03 188.49 l 222.26 186.77 l 225.49 185.65 l 228.71 183.95 l 231.94 181.79 l 235.17 180.48 l 238.39 179.46 l 241.62 178.14 l 244.85 176.23 l 248.07 174.77 l 251.30 173.44 l 254.53 172.46 l 257.75 171.43 l 260.98 169.77 l 264.21 168.30 l 267.44 167.23 l 270.66 166.35 l 273.89 165.41 l 277.12 163.95 l 280.34 162.60 l 283.57 161.35 l 286.80 160.40 l 290.02 159.48 l 293.25 158.46 l 296.48 157.71 l 299.71 156.74 l 302.93 155.79 l 306.16 154.55 l 309.39 153.35 l S Q q 0.000 0.000 0.000 RG 0.75 w [] 0 d 1 J 1 j 10.00 M 54.46 48.47 m 441.69 48.47 l S 54.46 48.47 m 54.46 43.72 l S 119.00 48.47 m 119.00 43.72 l S 183.53 48.47 m 183.53 43.72 l S 248.07 48.47 m 248.07 43.72 l S 312.61 48.47 m 312.61 43.72 l S 377.15 48.47 m 377.15 43.72 l S 441.69 48.47 m 441.69 43.72 l S BT 0.000 0.000 0.000 rg /F2 1 Tf 11.00 0.00 -0.00 11.00 51.40 31.36 Tm (0) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 106.76 31.36 Tm (1000) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 171.30 31.36 Tm (2000) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 235.84 31.36 Tm (3000) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 300.38 31.36 Tm (4000) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 364.92 31.36 Tm (5000) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 429.46 31.36 Tm (6000) Tj ET 38.97 58.20 m 38.97 301.39 l S 38.97 58.20 m 34.21 58.20 l S 38.97 106.84 m 34.21 106.84 l S 38.97 155.47 m 34.21 155.47 l S 38.97 204.11 m 34.21 204.11 l S 38.97 252.75 m 34.21 252.75 l S 38.97 301.39 m 34.21 301.39 l S BT /F2 1 Tf 0.00 11.00 -11.00 0.00 27.56 55.14 Tm (0) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 27.56 100.72 Tm (20) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 27.56 149.36 Tm (40) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 27.56 198.00 Tm (60) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 27.56 246.63 Tm (80) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 27.56 292.21 Tm (100) Tj ET 38.97 48.47 m 457.18 48.47 l 457.18 311.12 l 38.97 311.12 l 38.97 48.47 l S Q q 0.00 0.00 477.14 350.08 re W n BT 0.000 0.000 0.000 rg /F3 1 Tf 13.00 0.00 -0.00 13.00 221.17 325.93 Tm (PeakSeq) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 188.02 12.36 Tm (Number of ranked peaks) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 8.55 133.95 Tm (% peaks with motif) Tj ET Q q 38.97 48.47 418.22 262.65 re W n 0.000 0.000 1.000 RG 1.50 w [] 0 d 1 J 1 j 10.00 M 57.68 189.52 m 60.91 218.70 l 64.14 230.05 l 67.36 227.22 l 70.59 227.46 l 73.82 233.30 l 77.04 232.60 l 80.27 235.73 l 83.50 234.75 l 86.73 237.27 l 89.95 240.19 l 93.18 237.41 l 96.41 236.07 l 99.63 236.54 l 102.86 236.03 l 106.09 237.59 l 109.31 236.00 l 112.54 235.86 l 115.77 236.21 l 119.00 234.45 l 122.22 233.07 l 125.45 231.82 l 128.68 231.27 l 131.90 230.77 l 135.13 229.18 l 138.36 227.71 l 141.58 226.17 l 144.81 224.91 l 148.04 223.73 l 151.26 222.47 l 154.49 220.98 l 157.72 219.88 l 160.95 218.42 l 164.17 216.90 l 167.40 215.73 l 170.63 213.84 l 173.85 212.56 l 177.08 210.60 l 180.31 208.49 l 183.53 207.08 l 186.76 205.85 l 189.99 204.34 l 193.22 203.01 l 196.44 200.98 l 199.67 199.57 l 202.90 197.39 l 206.12 195.90 l 209.35 194.09 l 212.58 192.24 l 215.80 191.14 l 219.03 189.05 l 222.26 188.33 l 225.49 186.91 l 228.71 184.83 l 231.94 182.66 l 235.17 181.41 l 238.39 180.30 l 241.62 178.56 l 244.85 177.04 l 248.07 175.41 l 251.30 174.22 l 254.53 173.46 l 257.75 171.81 l 260.98 170.14 l 264.21 168.89 l 267.44 167.67 l 270.66 166.78 l 273.89 165.55 l 277.12 164.79 l 280.34 163.83 l 283.57 162.36 l S 0.000 1.000 0.000 RG 57.68 223.57 m 60.91 226.00 l 64.14 236.54 l 67.36 236.94 l 70.59 236.21 l 73.82 237.35 l 77.04 240.94 l 80.27 243.02 l 83.50 240.59 l 86.73 243.02 l 89.95 245.05 l 93.18 243.40 l 96.41 241.98 l 99.63 242.05 l 102.86 241.81 l 106.09 241.31 l 109.31 241.40 l 112.54 240.98 l 115.77 239.86 l 119.00 238.62 l 122.22 237.27 l 125.45 234.14 l 128.68 234.71 l 131.90 233.10 l 135.13 232.17 l 138.36 229.69 l 141.58 228.78 l 144.81 227.76 l 148.04 227.13 l 151.26 225.14 l 154.49 224.02 l 157.72 222.09 l 160.95 220.71 l 164.17 219.54 l 167.40 218.30 l 170.63 216.21 l 173.85 214.22 l 177.08 212.47 l 180.31 210.92 l 183.53 209.33 l 186.76 207.35 l 189.99 206.04 l 193.22 204.44 l 196.44 203.25 l 199.67 200.41 l 202.90 198.63 l 206.12 196.51 l 209.35 194.09 l 212.58 193.12 l 215.80 192.10 l 219.03 190.27 l 222.26 188.14 l 225.49 187.27 l 228.71 186.07 l 231.94 184.05 l S 1.000 0.000 0.000 RG 57.68 228.43 m 60.91 235.73 l 64.14 239.78 l 67.36 244.24 l 70.59 244.97 l 73.82 246.27 l 77.04 247.89 l 80.27 248.49 l 83.50 246.43 l 86.73 248.33 l 89.95 248.29 l 93.18 247.14 l 96.41 245.11 l 99.63 245.94 l 102.86 244.54 l 106.09 244.74 l 109.31 244.10 l 112.54 244.05 l 115.77 243.02 l 119.00 241.17 l 122.22 241.03 l 125.45 239.85 l 128.68 237.96 l 131.90 237.38 l 135.13 235.73 l 138.36 233.48 l 141.58 231.56 l 144.81 229.44 l 148.04 228.92 l 151.26 227.80 l 154.49 225.70 l 157.72 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1 Tf 0.00 11.00 -11.00 0.00 27.56 993.12 Tm (100) Tj ET 38.97 749.14 m 460.93 749.14 l 460.93 1012.03 l 38.97 1012.03 l 38.97 749.14 l S Q q 0.00 700.67 480.89 350.33 re W n BT 0.000 0.000 0.000 rg /F3 1 Tf 13.00 0.00 -0.00 13.00 226.11 1026.85 Tm (SISSRS) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 189.89 713.02 Tm (Number of ranked peaks) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 8.55 834.74 Tm (% peaks with motif) Tj ET Q q 38.97 749.14 421.96 262.90 re W n 0.000 0.000 1.000 RG 1.50 w [] 0 d 1 J 1 j 10.00 M 57.85 982.82 m 61.11 975.52 l 64.36 964.97 l 67.62 964.56 l 70.87 962.37 l 74.13 962.54 l 77.39 959.87 l 80.64 959.70 l 83.90 961.18 l 87.15 959.45 l 90.41 958.48 l 93.67 957.26 l 96.92 955.86 l 100.18 954.65 l 103.43 953.29 l 106.69 954.22 l 109.94 952.46 l 113.20 951.45 l 116.46 950.02 l 119.71 948.01 l 122.97 946.19 l 126.22 945.42 l 129.48 944.72 l 132.74 942.25 l 135.99 940.95 l 139.25 939.57 l 142.50 937.74 l 145.76 936.05 l 149.02 934.64 l 152.27 933.32 l 155.53 932.72 l 158.78 929.88 l 162.04 928.53 l 165.29 927.26 l 168.55 925.37 l 171.81 923.32 l 175.06 922.03 l 178.32 920.43 l 181.57 918.66 l 184.83 916.85 l 188.09 914.78 l 191.34 913.50 l 194.60 911.49 l 197.85 910.02 l 201.11 908.06 l 204.37 906.83 l 207.62 905.13 l 210.88 903.30 l 214.13 901.75 l 217.39 900.35 l 220.65 898.72 l 223.90 896.78 l 227.16 895.28 l 230.41 894.11 l 233.67 892.36 l 236.92 890.93 l 240.18 889.64 l 243.44 888.05 l 246.69 886.77 l 249.95 885.29 l 253.20 883.62 l 256.46 882.23 l 259.72 880.89 l 262.97 879.29 l 266.23 877.96 l 269.48 876.90 l 272.74 875.79 l 276.00 874.50 l 279.25 873.32 l 282.51 872.24 l 285.76 871.19 l 289.02 870.31 l 292.27 869.31 l 295.53 868.08 l 298.79 866.89 l 302.04 865.72 l 305.30 864.78 l 308.55 863.73 l 311.81 862.65 l 315.07 861.54 l 318.32 860.57 l 321.58 859.68 l 324.83 858.94 l 328.09 858.10 l 331.35 857.33 l 334.60 856.58 l 337.86 855.74 l 341.11 854.80 l 344.37 853.83 l 347.62 852.94 l 350.88 852.07 l 354.14 851.11 l 357.39 850.12 l 360.65 849.35 l 363.90 848.50 l 367.16 847.62 l S 0.000 1.000 0.000 RG 57.85 973.08 m 61.11 973.08 l 64.36 963.35 l 67.62 963.35 l 70.87 963.35 l 74.13 961.72 l 77.39 959.87 l 80.64 960.30 l 83.90 958.97 l 87.15 958.92 l 90.41 956.45 l 93.67 955.11 l 96.92 955.00 l 100.18 954.26 l 103.43 953.31 l 106.69 951.89 l 109.94 951.18 l 113.20 947.46 l 116.46 946.55 l 119.71 945.50 l 122.97 944.32 l 126.22 942.81 l 129.48 940.22 l 132.74 939.39 l 135.99 937.69 l 139.25 936.12 l 142.50 934.66 l 145.76 933.97 l 149.02 933.32 l 152.27 931.31 l 155.53 929.27 l 158.78 928.53 l 162.04 927.26 l 165.29 925.51 l 168.55 923.45 l 171.81 921.11 l 175.06 919.53 l 178.32 917.66 l 181.57 916.00 l 184.83 914.07 l 188.09 911.76 l 191.34 910.81 l 194.60 909.13 l 197.85 907.20 l 201.11 905.56 l 204.37 904.10 l 207.62 902.09 l 210.88 901.35 l 214.13 899.47 l 217.39 898.24 l 220.65 896.59 l 223.90 894.91 l 227.16 893.12 l 230.41 891.74 l 233.67 889.71 l 236.92 888.10 l 240.18 886.38 l 243.44 885.12 l 246.69 883.59 l 249.95 882.10 l 253.20 880.51 l 256.46 879.12 l 259.72 878.07 l 262.97 876.84 l 266.23 875.42 l 269.48 874.12 l 272.74 872.92 l 276.00 871.98 l 279.25 870.92 l 282.51 869.68 l 285.76 868.34 l 289.02 867.18 l 292.27 865.98 l 295.53 864.68 l 298.79 863.48 l 302.04 862.31 l 305.30 860.98 l S 1.000 0.000 0.000 RG 57.85 973.08 m 61.11 968.22 l 64.36 964.97 l 67.62 969.43 l 70.87 965.29 l 74.13 962.54 l 77.39 959.17 l 80.64 957.87 l 83.90 959.94 l 87.15 959.81 l 90.41 958.07 l 93.67 957.36 l 96.92 954.65 l 100.18 954.58 l 103.43 954.52 l 106.69 953.32 l 109.94 950.36 l 113.20 948.74 l 116.46 946.06 l 119.71 945.03 l 122.97 943.43 l 126.22 941.12 l 129.48 940.42 l 132.74 938.81 l 135.99 938.26 l 139.25 937.38 l 142.50 935.53 l 145.76 933.97 l 149.02 932.35 l 152.27 930.37 l 155.53 928.66 l 158.78 927.50 l 162.04 925.26 l 165.29 923.43 l 168.55 921.83 l 171.81 920.32 l 175.06 918.76 l 178.32 917.41 l 181.57 914.78 l 184.83 912.88 l 188.09 910.26 l 191.34 908.66 l 194.60 907.03 l 197.85 905.25 l 201.11 903.23 l 204.37 901.61 l 207.62 900.06 l 210.88 897.87 l 214.13 896.16 l 217.39 894.62 l 220.65 892.57 l 223.90 890.69 l 227.16 889.24 l 230.41 887.49 l 233.67 886.06 l 236.92 884.26 l 240.18 882.51 l 243.44 880.50 l 246.69 878.64 l 249.95 876.67 l 253.20 874.85 l 256.46 873.09 l 259.72 871.46 l 262.97 869.72 l 266.23 868.12 l 269.48 866.49 l 272.74 864.90 l 276.00 863.37 l S 0.000 0.000 0.000 RG 0.75 w [] 0 d 347.62 977.95 92.02 -57.02 re S 3.00 w [] 0 d 358.49 958.94 m 372.74 958.94 l S 0.000 0.000 1.000 RG 358.49 949.44 m 372.74 949.44 l S 0.000 1.000 0.000 RG 358.49 939.94 m 372.74 939.94 l S 1.000 0.000 0.000 RG 358.49 930.43 m 372.74 930.43 l S BT 0.000 0.000 0.000 rg /F2 1 Tf 11.00 0.00 -0.00 11.00 332.49 968.45 Tm ( Noise introduced ) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 379.87 955.00 Tm (None ) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 379.87 945.49 Tm (10%) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 379.87 935.99 Tm (30%) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 379.87 926.48 Tm (50%) Tj ET Q q 519.85 749.14 421.96 262.90 re W n Q q 519.85 749.14 421.96 262.90 re W n 0.000 0.000 0.000 RG 1.50 w [] 0 d 1 J 1 j 10.00 M 538.74 968.22 m 541.99 968.22 l 545.25 964.97 l 548.51 960.91 l 551.76 956.53 l 555.02 956.86 l 558.27 959.17 l 561.53 960.30 l 564.79 958.48 l 568.04 957.59 l 571.30 956.45 l 574.55 952.86 l 577.81 953.26 l 581.07 951.66 l 584.32 951.18 l 587.58 950.75 l 590.83 950.91 l 594.09 949.77 l 597.34 947.04 l 600.60 946.19 l 603.86 944.32 l 607.11 944.08 l 610.37 943.67 l 613.62 942.12 l 616.88 939.19 l 620.14 937.20 l 623.39 935.53 l 626.65 934.47 l 629.90 933.00 l 633.16 931.15 l 636.42 930.18 l 639.67 928.68 l 642.93 926.40 l 646.18 923.84 l 649.44 920.48 l 652.69 916.64 l S Q q 0.000 0.000 0.000 RG 0.75 w [] 0 d 1 J 1 j 10.00 M 535.48 749.14 m 926.19 749.14 l S 535.48 749.14 m 535.48 744.38 l S 600.60 749.14 m 600.60 744.38 l S 665.72 749.14 m 665.72 744.38 l S 730.84 749.14 m 730.84 744.38 l S 795.95 749.14 m 795.95 744.38 l S 861.07 749.14 m 861.07 744.38 l S 926.19 749.14 m 926.19 744.38 l S BT 0.000 0.000 0.000 rg /F2 1 Tf 11.00 0.00 -0.00 11.00 532.42 732.03 Tm (0) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 588.37 732.03 Tm (1000) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 653.49 732.03 Tm (2000) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 718.60 732.03 Tm (3000) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 783.72 732.03 Tm (4000) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 848.84 732.03 Tm (5000) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 913.96 732.03 Tm (6000) Tj ET 519.85 758.87 m 519.85 1002.29 l S 519.85 758.87 m 515.10 758.87 l S 519.85 807.56 m 515.10 807.56 l S 519.85 856.24 m 515.10 856.24 l S 519.85 904.93 m 515.10 904.93 l S 519.85 953.61 m 515.10 953.61 l S 519.85 1002.29 m 515.10 1002.29 l S BT /F2 1 Tf 0.00 11.00 -11.00 0.00 508.45 755.81 Tm (0) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 508.45 801.44 Tm (20) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 508.45 850.13 Tm (40) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 508.45 898.81 Tm (60) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 508.45 947.49 Tm (80) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 508.45 993.12 Tm (100) Tj ET 519.85 749.14 m 941.82 749.14 l 941.82 1012.03 l 519.85 1012.03 l 519.85 749.14 l S Q q 480.89 700.67 480.89 350.33 re W n BT 0.000 0.000 0.000 rg /F3 1 Tf 13.00 0.00 -0.00 13.00 691.83 1026.85 Tm (Sole-Search) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 670.78 713.02 Tm (Number of ranked peaks) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 489.44 834.74 Tm (% peaks with motif) Tj ET Q q 519.85 749.14 421.96 262.90 re W n 0.000 0.000 1.000 RG 1.50 w [] 0 d 1 J 1 j 10.00 M 538.74 963.35 m 541.99 963.35 l 545.25 963.35 l 548.51 958.48 l 551.76 954.58 l 555.02 956.04 l 558.27 957.78 l 561.53 958.48 l 564.79 957.02 l 568.04 957.15 l 571.30 954.42 l 574.55 952.86 l 577.81 951.87 l 581.07 951.01 l 584.32 949.65 l 587.58 950.17 l 590.83 947.93 l 594.09 946.95 l 597.34 945.58 l 600.60 944.11 l 603.86 942.55 l 607.11 941.33 l 610.37 940.63 l 613.62 939.78 l 616.88 937.32 l 620.14 935.40 l 623.39 933.09 l 626.65 931.95 l 629.90 930.89 l 633.16 929.27 l 636.42 927.75 l 639.67 926.32 l 642.93 924.69 l 646.18 922.31 l 649.44 919.94 l 652.69 918.35 l 655.95 915.18 l S 0.000 1.000 0.000 RG 538.74 958.48 m 541.99 965.78 l 545.25 958.48 l 548.51 959.70 l 551.76 956.53 l 555.02 957.67 l 558.27 957.78 l 561.53 957.87 l 564.79 956.04 l 568.04 954.94 l 571.30 954.42 l 574.55 952.11 l 577.81 951.18 l 581.07 950.36 l 584.32 950.87 l 587.58 950.75 l 590.83 948.20 l 594.09 946.69 l 597.34 945.82 l 600.60 944.57 l 603.86 942.77 l 607.11 941.76 l 610.37 940.83 l 613.62 938.81 l 616.88 936.76 l 620.14 934.14 l 623.39 933.27 l 626.65 932.29 l 629.90 930.57 l 633.16 929.27 l 636.42 926.99 l 639.67 922.04 l S 1.000 0.000 0.000 RG 538.74 968.22 m 541.99 965.78 l 545.25 963.35 l 548.51 959.70 l 551.76 958.48 l 555.02 959.29 l 558.27 960.57 l 561.53 957.87 l 564.79 955.07 l 568.04 954.05 l 571.30 953.20 l 574.55 952.49 l 577.81 951.18 l 581.07 950.36 l 584.32 950.26 l 587.58 949.60 l 590.83 949.28 l 594.09 947.20 l 597.34 945.33 l 600.60 944.11 l 603.86 942.55 l 607.11 940.70 l 610.37 939.61 l 613.62 938.03 l 616.88 936.38 l 620.14 934.32 l 623.39 928.22 l S 0.000 0.000 0.000 RG 0.75 w [] 0 d 828.51 977.95 92.02 -57.02 re S 3.00 w [] 0 d 839.38 958.94 m 853.63 958.94 l S 0.000 0.000 1.000 RG 839.38 949.44 m 853.63 949.44 l S 0.000 1.000 0.000 RG 839.38 939.94 m 853.63 939.94 l S 1.000 0.000 0.000 RG 839.38 930.43 m 853.63 930.43 l S BT 0.000 0.000 0.000 rg /F2 1 Tf 11.00 0.00 -0.00 11.00 813.38 968.45 Tm ( Noise introduced ) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 860.76 955.00 Tm (None ) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 860.76 945.49 Tm (10%) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 860.76 935.99 Tm (30%) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 860.76 926.48 Tm (50%) Tj ET Q q 38.97 398.80 421.96 262.90 re W n Q q 38.97 398.80 421.96 262.90 re W n 0.000 0.000 0.000 RG 1.50 w [] 0 d 1 J 1 j 10.00 M 57.85 617.88 m 61.11 613.01 l 64.36 617.88 l 67.62 613.01 l 70.87 611.07 l 74.13 611.39 l 77.39 610.23 l 80.64 610.58 l 83.90 606.69 l 87.15 606.82 l 90.41 607.33 l 93.67 604.40 l 96.92 602.58 l 100.18 603.60 l 103.43 601.45 l 106.69 600.13 l 109.94 599.22 l 113.20 598.41 l 116.46 597.92 l 119.71 594.93 l 122.97 594.43 l 126.22 592.27 l 129.48 591.92 l 132.74 590.04 l 135.99 587.92 l 139.25 586.33 l 142.50 584.85 l 145.76 582.80 l 149.02 580.88 l 152.27 580.35 l 155.53 578.17 l 158.78 575.98 l 162.04 575.07 l 165.29 573.51 l 168.55 571.77 l 171.81 570.38 l 175.06 568.30 l 178.32 566.33 l 181.57 564.94 l 184.83 563.26 l 188.09 562.01 l 191.34 559.24 l S Q q 0.000 0.000 0.000 RG 0.75 w [] 0 d 1 J 1 j 10.00 M 54.59 398.80 m 445.30 398.80 l S 54.59 398.80 m 54.59 394.05 l S 119.71 398.80 m 119.71 394.05 l S 184.83 398.80 m 184.83 394.05 l S 249.95 398.80 m 249.95 394.05 l S 315.07 398.80 m 315.07 394.05 l S 380.18 398.80 m 380.18 394.05 l S 445.30 398.80 m 445.30 394.05 l S BT 0.000 0.000 0.000 rg /F2 1 Tf 11.00 0.00 -0.00 11.00 51.54 381.70 Tm (0) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 107.48 381.70 Tm (1000) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 172.60 381.70 Tm (2000) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 237.72 381.70 Tm (3000) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 302.83 381.70 Tm (4000) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 367.95 381.70 Tm (5000) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 433.07 381.70 Tm (6000) Tj ET 38.97 408.54 m 38.97 651.96 l S 38.97 408.54 m 34.21 408.54 l S 38.97 457.22 m 34.21 457.22 l S 38.97 505.91 m 34.21 505.91 l S 38.97 554.59 m 34.21 554.59 l S 38.97 603.28 m 34.21 603.28 l S 38.97 651.96 m 34.21 651.96 l S BT /F2 1 Tf 0.00 11.00 -11.00 0.00 27.56 405.48 Tm (0) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 27.56 451.11 Tm (20) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 27.56 499.79 Tm (40) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 27.56 548.48 Tm (60) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 27.56 597.16 Tm (80) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 27.56 642.79 Tm (100) Tj ET 38.97 398.80 m 460.93 398.80 l 460.93 661.70 l 38.97 661.70 l 38.97 398.80 l S Q q 0.00 350.33 480.89 350.33 re W n BT 0.000 0.000 0.000 rg /F3 1 Tf 13.00 0.00 -0.00 13.00 231.53 676.52 Tm (MCPF) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 189.89 362.69 Tm (Number of ranked peaks) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 8.55 484.40 Tm (% peaks with motif) Tj ET Q q 38.97 398.80 421.96 262.90 re W n 0.000 0.000 1.000 RG 1.50 w [] 0 d 1 J 1 j 10.00 M 57.85 617.88 m 61.11 615.45 l 64.36 617.88 l 67.62 611.80 l 70.87 611.07 l 74.13 610.58 l 77.39 610.23 l 80.64 611.19 l 83.90 606.69 l 87.15 607.26 l 90.41 608.15 l 93.67 605.15 l 96.92 602.93 l 100.18 602.95 l 103.43 600.84 l 106.69 600.70 l 109.94 599.22 l 113.20 598.15 l 116.46 598.41 l 119.71 596.32 l 122.97 594.43 l 126.22 592.27 l 129.48 591.71 l 132.74 590.23 l 135.99 588.48 l 139.25 587.41 l 142.50 584.85 l 145.76 583.47 l 149.02 582.02 l 152.27 580.03 l 155.53 578.78 l 158.78 578.05 l 162.04 576.07 l 165.29 574.21 l 168.55 572.99 l 171.81 570.91 l 175.06 568.81 l 178.32 567.83 l 181.57 566.28 l 184.83 565.04 l 188.09 563.05 l 191.34 561.39 l 194.60 559.13 l S 0.000 1.000 0.000 RG 57.85 617.88 m 61.11 615.45 l 64.36 617.88 l 67.62 610.58 l 70.87 611.07 l 74.13 610.58 l 77.39 610.93 l 80.64 610.58 l 83.90 605.71 l 87.15 606.38 l 90.41 606.12 l 93.67 604.78 l 96.92 602.93 l 100.18 601.98 l 103.43 601.15 l 106.69 600.70 l 109.94 600.30 l 113.20 598.67 l 116.46 597.19 l 119.71 595.86 l 122.97 593.76 l 126.22 592.48 l 129.48 591.71 l 132.74 589.26 l 135.99 587.36 l 139.25 585.61 l 142.50 584.85 l 145.76 584.31 l 149.02 582.02 l 152.27 580.66 l 155.53 579.09 l 158.78 577.16 l 162.04 576.07 l 165.29 574.62 l 168.55 573.26 l 171.81 571.44 l 175.06 570.10 l 178.32 568.07 l 181.57 564.33 l S 1.000 0.000 0.000 RG 57.85 627.62 m 61.11 615.45 l 64.36 614.64 l 67.62 614.23 l 70.87 610.09 l 74.13 611.39 l 77.39 611.62 l 80.64 611.80 l 83.90 606.20 l 87.15 605.93 l 90.41 605.31 l 93.67 604.03 l 96.92 602.93 l 100.18 602.30 l 103.43 601.45 l 106.69 600.13 l 109.94 599.49 l 113.20 598.41 l 116.46 597.68 l 119.71 595.40 l 122.97 593.98 l 126.22 594.18 l 129.48 592.53 l 132.74 589.84 l 135.99 587.92 l 139.25 587.05 l 142.50 585.37 l 145.76 584.31 l 149.02 582.67 l 152.27 581.76 l 155.53 581.07 l 158.78 576.87 l S 0.000 0.000 0.000 RG 0.75 w [] 0 d 347.62 627.62 92.02 -57.02 re S 3.00 w [] 0 d 358.49 608.61 m 372.74 608.61 l S 0.000 0.000 1.000 RG 358.49 599.11 m 372.74 599.11 l S 0.000 1.000 0.000 RG 358.49 589.60 m 372.74 589.60 l S 1.000 0.000 0.000 RG 358.49 580.10 m 372.74 580.10 l S BT 0.000 0.000 0.000 rg /F2 1 Tf 11.00 0.00 -0.00 11.00 332.49 618.12 Tm ( Noise introduced ) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 379.87 604.66 Tm (None ) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 379.87 595.16 Tm (10%) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 379.87 585.65 Tm (30%) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 379.87 576.15 Tm (50%) Tj ET Q q 519.85 398.80 421.96 262.90 re W n Q q 519.85 398.80 421.96 262.90 re W n 0.000 0.000 0.000 RG 1.50 w [] 0 d 1 J 1 j 10.00 M 538.74 627.62 m 541.99 620.32 l 545.25 619.51 l 548.51 611.80 l 551.76 613.99 l 555.02 613.01 l 558.27 611.62 l 561.53 611.80 l 564.79 608.69 l 568.04 607.66 l 571.30 607.26 l 574.55 606.52 l 577.81 604.40 l 581.07 602.58 l 584.32 602.63 l 587.58 600.84 l 590.83 600.99 l 594.09 601.11 l 597.34 599.43 l 600.60 597.19 l 603.86 596.09 l 607.11 593.54 l 610.37 593.33 l 613.62 592.12 l 616.88 590.62 l 620.14 589.42 l 623.39 587.77 l 626.65 586.76 l 629.90 584.31 l 633.16 583.15 l 636.42 581.92 l 639.67 580.76 l 642.93 579.23 l 646.18 576.21 l 649.44 575.04 l 652.69 573.26 l 655.95 571.44 l 659.21 570.22 l 662.46 568.95 l 665.72 566.64 l 668.97 564.57 l 672.23 562.59 l 675.49 561.61 l 678.74 559.90 l 682.00 557.84 l 685.25 555.76 l 688.51 554.49 l 691.77 552.67 l 695.02 551.02 l 698.28 549.53 l 701.53 547.82 l 704.79 546.45 l 708.05 544.49 l 711.30 542.51 l 714.56 540.96 l 717.81 539.47 l 721.07 537.94 l 724.32 536.04 l 727.58 534.38 l 730.84 532.93 l 734.09 531.45 l 737.35 530.33 l 740.60 529.09 l 743.86 527.74 l 747.12 526.43 l 750.37 525.09 l 753.63 523.64 l 756.88 522.02 l 760.14 520.51 l 763.40 518.98 l 766.65 517.77 l 769.91 516.59 l 773.16 515.65 l 776.42 514.46 l 779.67 513.24 l 782.93 512.12 l 786.19 510.90 l 789.44 509.78 l 792.70 508.62 l 795.95 507.61 l 799.21 506.81 l 802.47 505.97 l 805.72 505.03 l 808.98 504.58 l 812.23 503.67 l 815.49 502.80 l 818.75 501.99 l 822.00 501.15 l 825.26 500.60 l 828.51 499.69 l 831.77 498.74 l 835.02 497.87 l 838.28 497.01 l 841.54 496.22 l 844.79 495.45 l 848.05 494.65 l S Q q 0.000 0.000 0.000 RG 0.75 w [] 0 d 1 J 1 j 10.00 M 535.48 398.80 m 926.19 398.80 l S 535.48 398.80 m 535.48 394.05 l S 600.60 398.80 m 600.60 394.05 l S 665.72 398.80 m 665.72 394.05 l S 730.84 398.80 m 730.84 394.05 l S 795.95 398.80 m 795.95 394.05 l S 861.07 398.80 m 861.07 394.05 l S 926.19 398.80 m 926.19 394.05 l S BT 0.000 0.000 0.000 rg /F2 1 Tf 11.00 0.00 -0.00 11.00 532.42 381.70 Tm (0) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 588.37 381.70 Tm (1000) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 653.49 381.70 Tm (2000) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 718.60 381.70 Tm (3000) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 783.72 381.70 Tm (4000) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 848.84 381.70 Tm (5000) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 913.96 381.70 Tm (6000) Tj ET 519.85 408.54 m 519.85 651.96 l S 519.85 408.54 m 515.10 408.54 l S 519.85 457.22 m 515.10 457.22 l S 519.85 505.91 m 515.10 505.91 l S 519.85 554.59 m 515.10 554.59 l S 519.85 603.28 m 515.10 603.28 l S 519.85 651.96 m 515.10 651.96 l S BT /F2 1 Tf 0.00 11.00 -11.00 0.00 508.45 405.48 Tm (0) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 508.45 451.11 Tm (20) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 508.45 499.79 Tm (40) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 508.45 548.48 Tm (60) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 508.45 597.16 Tm (80) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 508.45 642.79 Tm (100) Tj ET 519.85 398.80 m 941.82 398.80 l 941.82 661.70 l 519.85 661.70 l 519.85 398.80 l S Q q 480.89 350.33 480.89 350.33 re W n BT 0.000 0.000 0.000 rg /F3 1 Tf 13.00 0.00 -0.00 13.00 719.64 676.52 Tm (wtd) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 670.78 362.69 Tm (Number of ranked peaks) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 489.44 484.40 Tm (% peaks with motif) Tj ET Q q 519.85 398.80 421.96 262.90 re W n 0.000 0.000 1.000 RG 1.50 w [] 0 d 1 J 1 j 10.00 M 538.74 627.62 m 541.99 620.32 l 545.25 619.51 l 548.51 610.58 l 551.76 613.99 l 555.02 613.01 l 558.27 611.62 l 561.53 612.41 l 564.79 609.12 l 568.04 607.70 l 571.30 605.71 l 574.55 603.65 l 577.81 602.58 l 581.07 602.63 l 584.32 600.54 l 587.58 600.70 l 590.83 600.03 l 594.09 598.67 l 597.34 597.92 l 600.60 596.55 l 603.86 594.43 l 607.11 593.33 l 610.37 592.73 l 613.62 590.62 l 616.88 589.42 l 620.14 587.23 l 623.39 585.72 l 626.65 583.97 l 629.90 582.51 l 633.16 581.13 l 636.42 580.15 l 639.67 578.64 l 642.93 576.64 l 646.18 574.21 l 649.44 572.31 l 652.69 570.91 l 655.95 569.58 l 659.21 567.08 l 662.46 565.30 l 665.72 564.09 l 668.97 563.40 l 672.23 561.61 l 675.49 559.79 l 678.74 557.95 l 682.00 555.86 l 685.25 554.28 l 688.51 552.87 l 691.77 550.92 l 695.02 549.24 l 698.28 547.34 l 701.53 545.51 l 704.79 543.57 l 708.05 541.97 l 711.30 540.08 l 714.56 538.86 l 717.81 537.60 l 721.07 536.38 l 724.32 534.62 l 727.58 533.01 l 730.84 531.61 l 734.09 529.94 l 737.35 528.24 l 740.60 526.52 l 743.86 524.93 l 747.12 523.69 l 750.37 522.69 l 753.63 521.66 l 756.88 520.44 l 760.14 518.91 l 763.40 517.57 l 766.65 516.32 l 769.91 515.25 l 773.16 514.13 l 776.42 512.79 l 779.67 511.48 l 782.93 510.40 l 786.19 509.40 l 789.44 508.37 l 792.70 507.55 l 795.95 506.69 l 799.21 505.79 l 802.47 504.74 l 805.72 503.82 l 808.98 502.87 l 812.23 501.89 l 815.49 500.93 l S 0.000 1.000 0.000 RG 538.74 622.75 m 541.99 617.88 l 545.25 622.75 l 548.51 611.80 l 551.76 613.01 l 555.02 612.20 l 558.27 610.93 l 561.53 610.58 l 564.79 607.66 l 568.04 606.38 l 571.30 604.49 l 574.55 603.65 l 577.81 603.28 l 581.07 601.65 l 584.32 601.45 l 587.58 600.99 l 590.83 600.57 l 594.09 598.15 l 597.34 595.97 l 600.60 596.09 l 603.86 593.76 l 607.11 593.54 l 610.37 592.73 l 613.62 590.42 l 616.88 588.48 l 620.14 586.51 l 623.39 584.67 l 626.65 583.80 l 629.90 582.67 l 633.16 580.66 l 636.42 579.85 l 639.67 577.76 l 642.93 576.07 l 646.18 574.62 l 649.44 572.44 l 652.69 570.65 l 655.95 568.69 l 659.21 566.58 l 662.46 564.09 l 665.72 561.84 l 668.97 560.27 l 672.23 558.10 l 675.49 556.58 l 678.74 554.81 l 682.00 553.11 l 685.25 552.21 l 688.51 550.13 l 691.77 548.73 l 695.02 546.80 l 698.28 545.24 l 701.53 543.92 l 704.79 541.82 l 708.05 540.08 l 711.30 538.84 l 714.56 537.03 l 717.81 535.29 l 721.07 533.69 l 724.32 531.82 l 727.58 530.33 l 730.84 528.42 l 734.09 526.72 l 737.35 525.46 l 740.60 524.01 l 743.86 522.69 l 747.12 521.25 l 750.37 520.15 l 753.63 519.44 l 756.88 518.26 l 760.14 516.69 l S 1.000 0.000 0.000 RG 538.74 627.62 m 541.99 620.32 l 545.25 617.88 l 548.51 611.80 l 551.76 614.96 l 555.02 612.20 l 558.27 613.01 l 561.53 611.19 l 564.79 605.71 l 568.04 605.49 l 571.30 604.90 l 574.55 603.65 l 577.81 602.93 l 581.07 602.30 l 584.32 601.76 l 587.58 602.99 l 590.83 600.84 l 594.09 598.41 l 597.34 596.95 l 600.60 596.09 l 603.86 594.20 l 607.11 591.85 l 610.37 590.30 l 613.62 589.45 l 616.88 587.55 l 620.14 586.87 l 623.39 585.37 l 626.65 583.80 l 629.90 583.32 l 633.16 580.82 l 636.42 579.54 l 639.67 577.46 l 642.93 576.36 l 646.18 574.21 l 649.44 571.77 l 652.69 570.91 l 655.95 568.69 l 659.21 566.45 l 662.46 564.45 l 665.72 562.91 l 668.97 560.50 l 672.23 558.33 l 675.49 556.58 l 678.74 554.38 l 682.00 553.11 l 685.25 551.07 l 688.51 548.30 l 691.77 546.64 l 695.02 545.15 l 698.28 543.14 l 701.53 540.74 l S 0.000 0.000 0.000 RG 0.75 w [] 0 d 828.51 627.62 92.02 -57.02 re S 3.00 w [] 0 d 839.38 608.61 m 853.63 608.61 l S 0.000 0.000 1.000 RG 839.38 599.11 m 853.63 599.11 l S 0.000 1.000 0.000 RG 839.38 589.60 m 853.63 589.60 l S 1.000 0.000 0.000 RG 839.38 580.10 m 853.63 580.10 l S BT 0.000 0.000 0.000 rg /F2 1 Tf 11.00 0.00 -0.00 11.00 813.38 618.12 Tm ( Noise introduced ) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 860.76 604.66 Tm (None ) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 860.76 595.16 Tm (10%) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 860.76 585.65 Tm (30%) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 860.76 576.15 Tm (50%) Tj ET Q q 38.97 48.47 421.96 262.90 re W n Q q 38.97 48.47 421.96 262.90 re W n 0.000 0.000 0.000 RG 1.50 w [] 0 d 1 J 1 j 10.00 M 57.85 252.94 m 61.11 252.94 l 64.36 262.68 l 67.62 260.25 l 70.87 260.73 l 74.13 259.44 l 77.39 257.12 l 80.64 257.20 l 83.90 257.27 l 87.15 256.84 l 90.41 258.26 l 93.67 258.22 l 96.92 255.19 l 100.18 253.29 l 103.43 251.65 l 106.69 250.81 l 109.94 251.51 l 113.20 249.70 l 116.46 249.61 l 119.71 248.08 l 122.97 246.92 l 126.22 245.86 l 129.48 245.11 l 132.74 243.82 l 135.99 242.23 l 139.25 240.21 l 142.50 239.78 l 145.76 238.34 l 149.02 236.83 l 152.27 234.77 l 155.53 232.69 l 158.78 231.65 l 162.04 229.93 l 165.29 227.89 l 168.55 226.24 l 171.81 224.41 l 175.06 222.68 l 178.32 220.53 l 181.57 218.62 l 184.83 217.41 l 188.09 215.90 l 191.34 214.58 l 194.60 212.53 l 197.85 210.57 l 201.11 208.16 l 204.37 206.91 l 207.62 205.71 l 210.88 204.16 l 214.13 202.67 l 217.39 200.76 l 220.65 199.01 l 223.90 197.15 l 227.16 195.81 l 230.41 193.80 l 233.67 192.49 l 236.92 190.70 l 240.18 188.97 l 243.44 187.64 l 246.69 186.68 l 249.95 185.11 l 253.20 183.59 l 256.46 182.12 l 259.72 180.69 l 262.97 179.46 l 266.23 178.20 l 269.48 176.75 l 272.74 175.56 l 276.00 174.26 l 279.25 173.00 l 282.51 171.85 l 285.76 170.66 l 289.02 169.44 l 292.27 168.38 l 295.53 167.35 l 298.79 165.96 l 302.04 165.12 l 305.30 164.11 l 308.55 162.94 l 311.81 161.92 l 315.07 161.05 l 318.32 159.84 l 321.58 158.78 l 324.83 157.81 l 328.09 157.03 l 331.35 156.15 l 334.60 155.12 l 337.86 154.40 l 341.11 153.53 l 344.37 152.62 l 347.62 151.79 l 350.88 150.92 l 354.14 150.02 l 357.39 149.24 l 360.65 148.53 l 363.90 147.79 l 367.16 146.95 l 370.42 146.34 l 373.67 145.59 l 380.18 144.04 l 383.44 143.24 l 386.70 142.59 l 389.95 141.82 l 393.21 141.25 l 396.46 140.51 l 399.72 139.82 l 402.97 139.24 l 406.23 138.58 l 409.49 137.84 l 412.74 137.16 l 416.00 136.54 l 419.25 136.06 l 422.51 135.54 l 425.77 134.91 l 429.02 134.32 l 432.28 133.71 l 435.53 133.27 l 438.79 132.80 l 442.05 132.34 l 445.30 131.76 l 448.56 131.35 l 451.81 130.83 l 455.07 130.28 l 458.33 129.78 l 461.58 129.33 l 464.84 128.88 l 468.09 128.32 l 471.35 127.89 l 474.60 127.46 l 477.86 127.04 l 481.12 126.51 l 484.37 126.03 l 487.63 125.67 l 490.88 125.24 l 494.14 124.89 l 497.40 124.50 l 500.65 124.06 l 503.91 123.72 l 507.16 123.28 l 510.42 122.85 l 513.68 122.39 l 516.93 121.94 l 520.19 121.57 l 523.44 121.16 l 526.70 120.76 l 529.95 120.33 l 533.21 120.01 l 536.47 119.65 l 539.72 119.28 l 542.98 118.93 l 546.23 118.56 l 549.49 118.23 l 552.75 117.87 l 556.00 117.51 l 559.26 117.23 l 562.51 116.94 l 565.77 116.69 l 569.03 116.32 l 572.28 115.99 l 575.54 115.75 l 578.79 115.39 l 582.05 115.07 l 585.30 114.75 l 588.56 114.43 l 591.82 114.15 l 595.07 113.87 l 598.33 113.57 l 601.58 113.24 l 604.84 112.91 l 608.10 112.65 l 611.35 112.47 l 614.61 112.21 l 617.86 112.01 l 621.12 111.73 l 624.38 111.45 l 627.63 111.18 l 630.89 110.91 l 634.14 110.64 l 637.40 110.37 l 640.65 110.11 l 643.91 109.85 l 647.17 109.57 l 650.42 109.31 l 653.68 109.03 l 656.93 108.81 l 660.19 108.59 l 663.45 108.32 l 666.70 108.08 l 669.96 107.87 l 673.21 107.63 l S Q q 0.000 0.000 0.000 RG 0.75 w [] 0 d 1 J 1 j 10.00 M 54.59 48.47 m 445.30 48.47 l S 54.59 48.47 m 54.59 43.72 l S 119.71 48.47 m 119.71 43.72 l S 184.83 48.47 m 184.83 43.72 l S 249.95 48.47 m 249.95 43.72 l S 315.07 48.47 m 315.07 43.72 l S 380.18 48.47 m 380.18 43.72 l S 445.30 48.47 m 445.30 43.72 l S BT 0.000 0.000 0.000 rg /F2 1 Tf 11.00 0.00 -0.00 11.00 51.54 31.36 Tm (0) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 107.48 31.36 Tm (1000) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 172.60 31.36 Tm (2000) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 237.72 31.36 Tm (3000) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 302.83 31.36 Tm (4000) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 367.95 31.36 Tm (5000) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 433.07 31.36 Tm (6000) Tj ET 38.97 58.21 m 38.97 301.63 l S 38.97 58.21 m 34.21 58.21 l S 38.97 106.89 m 34.21 106.89 l S 38.97 155.58 m 34.21 155.58 l S 38.97 204.26 m 34.21 204.26 l S 38.97 252.94 m 34.21 252.94 l S 38.97 301.63 m 34.21 301.63 l S BT /F2 1 Tf 0.00 11.00 -11.00 0.00 27.56 55.15 Tm (0) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 27.56 100.78 Tm (20) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 27.56 149.46 Tm (40) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 27.56 198.14 Tm (60) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 27.56 246.83 Tm (80) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 27.56 292.46 Tm (100) Tj ET 38.97 48.47 m 460.93 48.47 l 460.93 311.37 l 38.97 311.37 l 38.97 48.47 l S Q q 0.00 0.00 480.89 350.33 re W n BT 0.000 0.000 0.000 rg /F3 1 Tf 13.00 0.00 -0.00 13.00 231.07 326.18 Tm (MACS) Tj ET BT /F2 1 Tf 11.00 0.00 -0.00 11.00 189.89 12.36 Tm (Number of ranked peaks) Tj ET BT /F2 1 Tf 0.00 11.00 -11.00 0.00 8.55 134.07 Tm (% peaks with motif) Tj ET Q q 38.97 48.47 421.96 262.90 re W n 0.000 0.000 1.000 RG 1.50 w [] 0 d 1 J 1 j 10.00 M 57.85 252.94 m 61.11 257.81 l 64.36 257.81 l 67.62 261.46 l 70.87 258.79 l 74.13 258.62 l 77.39 257.81 l 80.64 257.81 l 83.90 258.35 l 87.15 256.84 l 90.41 257.81 l 93.67 257.81 l 96.92 257.44 l 100.18 253.64 l 103.43 251.32 l 106.69 250.81 l 109.94 251.23 l 113.20 251.05 l 116.46 249.87 l 119.71 248.56 l 122.97 247.38 l 126.22 246.97 l 129.48 246.17 l 132.74 244.22 l 135.99 242.82 l 139.25 240.77 l 142.50 239.42 l 145.76 237.82 l 149.02 236.49 l 152.27 234.61 l 155.53 232.69 l 158.78 231.19 l 162.04 229.64 l 165.29 227.60 l 168.55 226.38 l 171.81 224.68 l 175.06 222.68 l 178.32 220.79 l 181.57 219.12 l 184.83 218.38 l 188.09 216.49 l 191.34 214.69 l 194.60 212.75 l 197.85 211.01 l 201.11 209.13 l 204.37 207.12 l 207.62 205.50 l 210.88 203.35 l 214.13 201.88 l 217.39 200.17 l 220.65 198.72 l 223.90 197.43 l 227.16 195.63 l 230.41 193.62 l 233.67 192.05 l 236.92 190.52 l 240.18 188.72 l 243.44 187.30 l 246.69 186.19 l 249.95 184.87 l 253.20 183.51 l 256.46 181.96 l 259.72 180.46 l 262.97 179.01 l 266.23 177.75 l 269.48 176.82 l 272.74 175.70 l 276.00 174.26 l 279.25 172.79 l 282.51 171.36 l 285.76 170.18 l 289.02 169.17 l 292.27 168.05 l 295.53 166.96 l 298.79 166.16 l 302.04 164.99 l 305.30 164.05 l 308.55 163.25 l 311.81 162.29 l 315.07 161.11 l 318.32 160.08 l 321.58 158.90 l 324.83 158.04 l 328.09 157.26 l 331.35 156.66 l 334.60 155.92 l 337.86 155.02 l 341.11 153.97 l 344.37 153.11 l 347.62 152.11 l 350.88 151.30 l 354.14 150.44 l 357.39 149.61 l 360.65 148.74 l 363.90 147.79 l 367.16 147.01 l 370.42 146.29 l 373.67 145.59 l 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