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Schematic of an octree spatial representation. (a) An octree allows for the representation of a three-dimensional volume with regions of varying resolution and is used to store the underlying structure over which chemical diffusion in BSim is calculated. Nodes in the data structure represent regions of space and children a further subdivision of the same region. (b) Boundaries are approximated using a recursive subdivision method. First, the lattice is divided into two regions by a mesh, represented as a dotted curve. Each square that contains a segment of the mesh is subdivided into four equal parts. This process continues recursively until a user specified number of subdivisions is reached, halting the process.

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