Peptide YY Secretion in Morbidly Obese Patients Before and After Vertical Banded Gastroplasty (original) (raw)

Background: The Peptide YY (PYY) secretion pattern was assessed in morbidly obese (MO) patients before and after vertical banded gastroplasty (VBG). Methods: 12 MO patients (10 women, 2 men) age 29-62 years, BMI 50.7 ± 9.6 kg/m2, treated with a VBG were studied. Before surgery, blood samples were taken in basal conditions of fasting and 10, 15, 20, 30 and 60 min after the ingestion of a semiliquid test meal. This was repeated in the same patients 6 and 12 months after VBG. Blood samples were also taken from 6 healthy non-obese subjects as controls. PYY plasma concentration was measured by radioimmunoassay with I125. Results: There were statistically significant differences between the preoperative PYY concentration in MO patients compared to controls. After a VBG, PYY concentration varied significantly compared to the preoperative levels.There was no significant difference between the PYY concentrations in the MO patients after VBG and the controls. Conclusion: PYY concentration is lower in MO patients compared with non-obese. After VBG, PYY concentration gradually rises to the control levels.

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Authors and Affiliations

  1. Department of Surgery, Hospital Clínico San Carlos, Madrid, Spain
    Mercedes Alvarez Bartolomé MD
  2. Department of Nuclear Medicine, Hospital Clínico San Carlos, Madrid, Spain
    María Borque MD
  3. Department of Surgery, Hospital Clínico San Carlos, Madrid, Spain
    Javier Martinez-Sarmiento MD
  4. Department of Surgery, Hospital Clínico San Carlos, Madrid, Spain
    Eugenio Aparicio MD
  5. Department of Surgery, Hospital Clínico San Carlos, Madrid, Spain
    Carmen Hernández MD
  6. Department of Endocrinology, Hospital Clínico San Carlos, Madrid, Spain
    Lucio Cabrerizo MD
  7. Department of Surgery, Hospital Clínico San Carlos, Madrid, Spain
    J A Fernández-Represa MD

Authors

  1. Mercedes Alvarez Bartolomé MD
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  2. María Borque MD
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  3. Javier Martinez-Sarmiento MD
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  4. Eugenio Aparicio MD
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  5. Carmen Hernández MD
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  6. Lucio Cabrerizo MD
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  7. J A Fernández-Represa MD
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Bartolomé, M.A., Borque, M., Martinez-Sarmiento, J. et al. Peptide YY Secretion in Morbidly Obese Patients Before and After Vertical Banded Gastroplasty.OBES SURG 12, 324–327 (2002). https://doi.org/10.1381/096089202321088084

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