Lipid Peroxidation in Bariatric Candidates with Nonalcoholic Fatty Liver Disease (NAFLD) – Preliminary Findings (original) (raw)

Background: Pathogenesis of nonalcoholic fatty liver disease (NAFLD) remains incompletely known, and oxidative stress is one of the mechanisms incriminated. The aim of this study was to evaluate the role of liver oxidative stress in NAFLD affecting morbidly obese patients. Methods: 39 consecutive patients with BMI >40 kg/m2 submitted to Roux-en-Y gastric bypass were enrolled, and wedge liver biopsy was obtained during operation. Oxidative stress was measured by concentration of hydroperoxides (CEOOH) in liver tissue. Results: Female gender was dominant (89.7%) and median age was 43.6 ± 11.1 years. Histology showed fatty liver in 92.3%, including 43.6% with nonalcoholic steatohepatitis (NASH), 48.7% with isolated steatosis and just 7.7% with normal liver. Liver cirrhosis was present in 11.7% of those with nonalcoholic steatohepatitis. Concentration of CEOOH was increased in the liver of patients with NASH when compared to isolated steatosis and normal liver (0.26± 0.17, 0.20± 0.01 and 0.14± 0.00 nmol/mg protein, respectively) (P <0.01). Liver biochemical variables were normal in 92.3% of all cases, and no difference between NASH and isolated steatosis could be demonstrated. Conclusions: 1) Nonalcoholic steatosis, steatohepatitis and cirrhosis were identified in substantial numbers of morbidly obese patients; 2) Concentration of hydroperoxides was increased in steatohepatitis, consistent with a pathogenetic role for oxidative stress in this condition.

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Authors and Affiliations

  1. Departments of Gastroenterology, University of São Paulo School of Medicine, Brazil
    Claudia P M S Oliveira
  2. Departments of Gastroenterology, University of São Paulo School of Medicine, Brazil
    Joel Faintuch
  3. Departments of Endocrinology, University of São Paulo School of Medicine, Brazil
    Alessandra Rascovski
  4. Departments of Gastroenterology, University of São Paulo School of Medicine, Brazil
    Carlos K Furuya Jr
  5. Departments of Endocrinology, University of São Paulo School of Medicine, Brazil
    Maria do Socorro Bastos
  6. Departments of Gastroenterology, University of São Paulo School of Medicine, Brazil
    Mitsunori Matsuda
  7. Departments of Gastroenterology, University of São Paulo School of Medicine, Brazil
    Bianca I Della Nina
  8. Department of Clinical and Toxicological Analysis, São Paulo University School of Pharmaceutical Sciences, São Paulo, Brazil
    Katia Yahnosi
  9. Department of Clinical and Toxicological Analysis, São Paulo University School of Pharmaceutical Sciences, São Paulo, Brazil
    Dulcineia S P Abdala
  10. Departments of Gastroenterology, University of São Paulo School of Medicine, Brazil
    Denise C P Vezozzo
  11. Departments of Pathology, University of São Paulo School of Medicine, Brazil
    Venancio A F Alves
  12. Departments of Gastroenterology, University of São Paulo School of Medicine, Brazil
    Bruno Zilberstein
  13. Departments of Gastroenterology, University of São Paulo School of Medicine, Brazil
    Arthur B Garrido Jr
  14. Departments of Endocrinology, University of São Paulo School of Medicine, Brazil
    Alfredo Halpern
  15. Departments of Gastroenterology, University of São Paulo School of Medicine, Brazil
    Flair J Carrilho
  16. Departments of Gastroenterology, University of São Paulo School of Medicine, Brazil
    J J Gama-Rodrigues

Authors

  1. Claudia P M S Oliveira
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  2. Joel Faintuch
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  3. Alessandra Rascovski
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  4. Carlos K Furuya Jr
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  5. Maria do Socorro Bastos
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  6. Mitsunori Matsuda
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  7. Bianca I Della Nina
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  8. Katia Yahnosi
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  9. Dulcineia S P Abdala
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  10. Denise C P Vezozzo
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  11. Venancio A F Alves
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  12. Bruno Zilberstein
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  13. Arthur B Garrido Jr
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  14. Alfredo Halpern
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  15. Flair J Carrilho
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  16. J J Gama-Rodrigues
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Oliveira, C.P.M.S., Faintuch, J., Rascovski, A. et al. Lipid Peroxidation in Bariatric Candidates with Nonalcoholic Fatty Liver Disease (NAFLD) – Preliminary Findings.OBES SURG 15, 502–505 (2005). https://doi.org/10.1381/0960892053723493

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