EMAP and EMAGE (original) (raw)

Abstract

The Edinburgh Mouse Atlas Project (EMAP) is a time-series of mouse-embryo volumetric models. The models provide a context-free spatial framework onto which structural interpretations and experimental data can be mapped. This enables collation, comparison, and query of complex spatial patterns with respect to each other and with respect to known or hypothesized structure. The atlas also includes a time-dependent anatomical ontology and mapping between the ontology and the spatial models in the form of delineated anatomical regions or tissues. The models provide a natural, graphical context for browsing and visualizing complex data.

The Edinburgh Mouse Atlas Gene-Expression Database (EMAGE) is one of the first applications of the EMAP framework and provides a spatially mapped gene-expression database with associated tools for data mapping, submission, and query. In this article, we describe the underlying principles of the Atlas and the gene-expression database, and provide a practical introduction to the use of the EMAP and EMAGE tools, including use of new techniques for whole body gene-expression data capture and mapping.

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Authors and Affiliations

1. MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh, UK
   Richard A. Baldock, Jonathan B. L. Bard, Albert Burger, Nicolas Burton, Jeff Christiansen, Guanjie Feng, Bill Hill, Derek Houghton, Matthew Kaufman, Jianguo Rao, James Sharpe, Allyson Ross, Peter Stevenson, Shanmugasundaram Venkataraman, Andrew Waterhouse, Yiya Yang & Duncan R. Davidson
2. Division of Biomedical Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, UK
   Jonathan B. L. Bard & Matthew Kaufman

Authors

1. Richard A. Baldock
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2. Jonathan B. L. Bard
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3. Albert Burger
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4. Nicolas Burton
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5. Jeff Christiansen
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6. Guanjie Feng
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7. Bill Hill
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8. Derek Houghton
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9. Matthew Kaufman
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10. Jianguo Rao
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11. James Sharpe
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12. Allyson Ross
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13. Peter Stevenson
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14. Shanmugasundaram Venkataraman
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15. Andrew Waterhouse
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16. Yiya Yang
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17. Duncan R. Davidson
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Corresponding author

Correspondence toRichard A. Baldock.

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Baldock, R.A., Bard, J.B.L., Burger, A. et al. EMAP and EMAGE.Neuroinform 1, 309–325 (2003). https://doi.org/10.1385/NI:1:4:309

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• Issue Date: December 2003
• DOI: https://doi.org/10.1385/NI:1:4:309

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