Resolved: EMT Produces Fibroblasts in the Kidney : Journal of the American Society of Nephrology (original) (raw)
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EMT Produces Fibroblasts in the Kidney
Correspondence: Dr. Michael Zeisberg, Harvard Medical School, Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, RW763C, Boston, MA 02215. Phone: 617-667-3583; Fax: 617-667-0360; E-mail: [email protected]; or Dr. Jeremy S. Duffield, Laboratory of Inflammation Research, Harvard Institutes of Medicine, 5th Floor, 4 Blackfan Circle, Boston, MA 02115. Phone: 617-525-5078; Fax: 617-525-5830; E-mail: [email protected]
Abstract
Epithelial-mesenchymal transition (EMT) is a mechanism for generating primitive mesenchymal cells during gastrulation or mobile tumor cells during cancer metastasis. For 15 years, EMT has also been viewed as a principal source of fibroblasts in tissue fibrosis. Because several recent studies question its role in fibrogenesis, it seems like a good time for debate.
Copyright © 2010 The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.
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