Cardiac and Vascular Adaptation in Pediatric Patients with... : Journal of the American Society of Nephrology (original) (raw)
Chronic Kidney Disease
Cardiac and Vascular Adaptation in Pediatric Patients with Chronic Kidney Disease
Role of Calcium-Phosphorus Metabolism
Mitsnefes, Mark M.*; Kimball, Thomas R.†; Kartal, Janis*; Witt, Sandra A.†; Glascock, Betty J.†; Khoury, Philip R.†; Daniels, Stephen R.†
*Nephrology and Hypertension; and †Cardiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio
Address correspondence to: Dr. Mark Mitsnefes, Division of Nephrology and Hypertension, Cincinnati Children’s Hospital, MLC 7022, 3333 Burnet Avenue, Cincinnati, OH 45229. Phone: 513-636-4531; Fax: 513-636-7407; [email protected]
Accepted June 24, 2005
Received March 17, 2005
Abstract
In children, cardiac abnormalities such as increased left ventricular mass (LVM) and diastolic dysfunction develop at the time of mild to moderate chronic renal insufficiency (CRI) and progress as renal function deteriorates. It was hypothesized that in this age group, vascular abnormalities develop early in the course of chronic kidney disease (CKD) in parallel with cardiac abnormalities and become more severe as end-stage disease is reached. Echocardiography and ultrasound of the carotid artery were performed on 44 patients with CKD stages 2 to 4 (CRI group), 16 patients who were on maintenance dialysis, and 35 healthy individuals. Carotid artery intima-media thickness (cIMT) was measured and distensibility and stiffness were calculated to assess carotid artery structure and function. Both the CRI and dialysis groups had greater cIMT, higher LVM index, and poorer diastolic function than the control subjects (P < 0.0001). Children who were on dialysis had greater cIMT and higher LVM index than those with CRI (P < 0.001) and greater arterial stiffness than both CRI patients and control subjects (P < 0.001). Arterial compliance was similar in CRI and control subjects. In all patients with CKD (CRI and dialysis), increased calcium-phosphorus product predicted increased cIMT. Increased serum phosphorus and intact parathyroid hormone predicted increased arterial stiffness. Elevated intact parathyroid hormone was a predictor of increased LVM index and poor diastolic function. In dialysis patients, the cumulative dose of phosphate binders and calcitriol predicted abnormal vascular structure and function. It is concluded that vascular abnormalities are already present in children and adolescents during early stages of CKD; they are more severe in children who are on maintenance dialysis and are related to abnormal calcium-phosphorus metabolism.
Copyright © 2005 The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.
Full Text Access for Subscribers:
