Mechanisms of Hypoxia Responses in Renal Tissue : Journal of the American Society of Nephrology (original) (raw)
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Departments of Medicine, Cancer Biology, and Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee
Correspondence: Dr. Volker H. Haase, Department of Medicine, Division of Nephrology and Hypertension, Vanderbilt University Medical Center, C-3119A, MCN, 1161 21st Avenue, Nashville, TN 37232. Email: [email protected]
Abstract
pO2 in the kidney is maintained at relatively stable levels by a unique and complex functional interplay between renal blood flow, GFR, O2 consumption, and arteriovenous O2 shunting. The fragility of this interplay makes the kidney susceptible to hypoxic injury. Cells in the kidney utilize various molecular pathways that allow them to respond and adapt to changes in renal oxygenation. This review provides an integrative perspective on the role of molecular hypoxia responses in normal kidney physiology and pathophysiology, and discusses their therapeutic potential for the treatment of renal diseases.
Copyright © 2013 The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.
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