Tsuchiya R, Noda T, Harada N, et al. Collective review of small carcinomas of the pancreas. Ann Surg 1986; 203: 77–81 ArticlePubMedCAS Google Scholar
DiMagno EP, Reber HA, Tempero MA. AGA technical review on the epidemiology, diagnosis and treatment of pancreatic ductal adenocarcinoma. Gastroenterology 1998; 117: 1464–84 Article Google Scholar
Douglass H. Adjuvant therapy for pancreatic cancer. World J Surg 1995; 19: 170–4 Article Google Scholar
American Cancer Society. Cancer facts and figures-1991. Atlanta (GA): American Cancer Society, 1991 Google Scholar
Connolly M, Dawson P, Michelassi F, et al. Survival in 1001 patients with carcinoma of the pancreas. Ann Surg 1987; 206: 366–73 ArticlePubMedCAS Google Scholar
Singh S, Longmire W, Reber H. Surgical palliation for pancreatic cancer: The UCLA experience. Ann Surg 1990; 212: 132–9 ArticlePubMedCAS Google Scholar
Ries LAG, Miller BA, Hankey BF, et al., editors. SEER cancer statistics review, 1973–1991: tables and graphs. NIH pub. no. 94-2789. Bethesda, MD: National Cancer Institute, 1994: 356–68 Google Scholar
Blackstock AW, Cox AD, Tepper JE. Treatment of pancreatic cancer: current limitations, future possibilities. Oncology 1996; 10: 301–30 PubMedCAS Google Scholar
Flanders TY, Foulkes WD. Pancreatic adenocarcinoma: epidemiology and genetics. J Med Genet 1996; 33: 889–98 ArticlePubMedCAS Google Scholar
Abruzzese JL. Pancreatic cancer: overview of current and future therapeutic approaches. Educational book of the American Society of Clinical Oncology, 33rd Annual Meeting, 1997: 65-70
Rivenson A, Hoffman D, Prokopczyk B, et al. Induction of lung and exocrine pancreatic tumors in F344 rats by tobacco-specific and Areca-derived N-nitrosamines. Cancer Res 1988; 48: 6912–7 PubMedCAS Google Scholar
Pour PM, Rivenson A. Induction of a mixed ductal-squamousislet cell carcinoma in a rat treated with a tobacco-specific carcinogen. Am J Pathol 1989; 134: 627–31 PubMedCAS Google Scholar
Hoffman D, Rivenson A, Chung FL, et al. Nicotine-derived N-nitrosamines (TSNA) and their relevance in tobacco carcinogenesis. Crit Rev Toxicol 1991; 21: 305–11 Article Google Scholar
Ogawa T, Makino T, Mizumoto K, et al. Promoting effect of truncal vagotomy on pancreatic carcinogenesis initiated with N-nitrosobis-(2-oxopropyl) amine in Syrian golden hamsters. Carcinogenesis 1991; 12: 1227–30 ArticlePubMedCAS Google Scholar
Corra S, Kazakoff K, Lawson TA, et al. Cholecystokinin inhibits DNA alkylation induced by N-nitrosobis (2-oxopropyl) amine (BOP) in hamster pancreas. Cancer Lett 1992; 62: 251–6 ArticlePubMedCAS Google Scholar
Hoffman D, Rivenson A, Abbi R, et al. A study of tobacco carcinogenesis: Effect of the fat content of the diet on the carcinogenic activity of 4 (methylnitros-amino)-1-(3-pyridyl)-1-butanone in F344 rats. Cancer Res 1993; 53: 2758–61 Google Scholar
Rosenberg L, Brown RA, Duguid WP. Development of experimental cancer in the head of the pancreas by surgical induction of tissue injury. Am J Surg 1984; 147: 146–51 ArticlePubMedCAS Google Scholar
Silverman DT, Dunn JA, Hoover RN, et al. Cigarette smoking and pancreas cancer: a case-control study based on direct interviews. J Natl Cancer Inst 1994; 86: 1510–6 ArticlePubMedCAS Google Scholar
La Vecchia C, Boyle P, Francesschi S, et al. Smoking and cancer with emphasis on Europe. Eur J Cancer 1991; 27: 94–104 ArticlePubMed Google Scholar
Yeo C, Cameron J, Lillemoe K, et al. Pancreaticoduodenectomy for cancer of the head of the pancreas. Ann Surg 1995; 221: 721–33 ArticlePubMedCAS Google Scholar
Rothenberg ML. New developments in chemotherapy for patients with advanced pancreatic cancer. Oncology 1996; 10: 18–22 PubMedCAS Google Scholar
Rothenberg ML, Abbruzzese JL, Moore M, et al. A rationale for expanding the endpoints for clinical trials in advanced pancreatic carcinoma. Cancer 1996; 78 (3 Suppl.): 627–32 PubMedCAS Google Scholar
Andersen JR, Friss-Mollek A, Hancke S, et al. A controlled trial of combination chemotherapy with 5-FU and BCNU in pancreatic adenocarcinoma. Scand J Gastroenterol 1981; 16: 973 ArticlePubMedCAS Google Scholar
Frey C, Twomey P, Keehn R, et al. Randomized study of 5-FU and CCNU in pancreatic cancer: report of the Veterans Administration Surgical Adjuvant Cancer Chemotherapy Study Group. Cancer 1981; 47: 27–32 ArticlePubMedCAS Google Scholar
Mallinson CN, Rake MO, Cocking JB, et al. Chemotherapy in pancreatic cancer: results of a controlled, prospective, randomised, multicentre trial. BMJ 1980; 281: 1589–91 ArticlePubMedCAS Google Scholar
Cullinan S, Moertel CG, Wieand HS, et al. A phase III trial on the therapy of advanced pancreatic cancer: evaluations of the Mallinson regimen and combined 5-fluorouracil, doxorubicin, and cisplatin. Cancer 1990; 65: 2207–12 ArticlePubMedCAS Google Scholar
Kelsen D. The use of chemotherapy in the treatment of advanced gastric and pancreatic cancer. Semin Oncol 1994; 21: 58–66 PubMedCAS Google Scholar
Bukowski RM. Role of chemotherapy in patients with adenocarcinoma of the pancreas. Adv Oncol 1995; 11: 25 Google Scholar
Carter SK. The integration of chemotherapy into a combined modality approach for cancer treatment. VI. Pancreatic adenocarcinoma. Cancer Treat Rev 1975; 3: 193 Google Scholar
Hubbard KP, Pazdur R, Ajani JA, et al. Phase II evaluation of iproplatin in patients with advanced gastric and pancreatic cancer. Am J Clin Oncol 1992; 15: 524–7 PubMedCAS Google Scholar
Carlson RW, Doroshow JH, Odujinrin OO, et al. Trimetrexate in locally advanced or metastatic adenocarcinoma of the pancreas: a phase II study of the Northern California Oncology Group. Invest New Drugs 1990; 8: 387–9 ArticlePubMedCAS Google Scholar
Casper ES, Schwartz GK, Johnson B, et al. Phase II trial of edatrexate in patients with advanced pancreatic cancer. Invest New Drugs 1992; 10: 313–6 ArticlePubMedCAS Google Scholar
Casper ES, Schwartz GK, Kelsen DP. Phase II trial of fazarabine (arabinofuranosyl-5-azacytidine) in patients with advanced pancreatic adenocarcinoma. Invest New Drugs 1992; 10: 205–9 ArticlePubMedCAS Google Scholar
Bukowski RM, Fleming TR, MacDonald JS, et al. Evaluation of combination chemotherapy and phase II agents in pancreatic adenocarcinoma: an Oncology Group study. Cancer 1993; 71: 322–5 ArticlePubMedCAS Google Scholar
Linke K, Pazdur R, Abbruzzese J, et al. Phase II study of amonafide in advanced pancreatic adenocarcinoma. Invest New Drugs 1991; 9: 353–6 ArticlePubMedCAS Google Scholar
Hertel LW, Boder GB, Kroin JS, et al. Evaluation of the antitumor activity of gemcitabine (2′,2′-difluoro-2′-deoxycytidine). Cancer Res 1990; 50: 4417–22 PubMedCAS Google Scholar
Heinemann V, Hertel LW, Grindley GB, et al. Comparison of the cellular pharmacokinetics and toxicity of 2′,2′-difluoro-2′-deoxycytidine and 1-β-D arabinofuranosylcytosine. Cancer 1988; 48: 4024–31 CAS Google Scholar
Abbruzzese JL, Grunewald R, Weeks EA, et al. A phase I clinical, plasma and cellular pharmacology study of gemcitabine. J Clin Oncol 1991; 9: 491–8 PubMedCAS Google Scholar
Casper ES, Green MR, Kelsen DP, et al. Phase II trial of gemcitabine (2′,2′-difluoro-2′-deoxycytidine) in patients with adenocarcinoma of the pancreas. Invest New Drugs 1994; 12: 29–34 ArticlePubMedCAS Google Scholar
Burris III HA, Moore MJ, Andersen J, et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 1997; 15: 2403–13 PubMedCAS Google Scholar
Rothenberg ML, Moore MJ, Cripps MC, et al. A phase II trial of gemcitabine in patients with 5-FU-refractory pancreas cancer. Ann Oncol 1996; 7: 347–53 ArticlePubMedCAS Google Scholar
Gelber RD. Gemcitabine for pancreatic cancer: how hard to look for clinical benefit? An American perspective. Ann Oncol 1996; 7: 335–7 ArticlePubMedCAS Google Scholar
Lawrence TS, Chang EY, Hahn T, et al. Radiosensitization of pancreatic cancer cells by 2′,2′-difluoro-2′deoxycytidine. Int J Radiat Oncol Biol Phys 1996; 34: 867–72 ArticlePubMedCAS Google Scholar
Hoffman JP, McGinn CJ, Szarka C, et al. A phase I study of preoperative gemcitabine with radiation therapy followed by postoperative gemcitabine for patients with localized, resectable pancreatic adenocarcinoma. Proc Am Soc Clin Oncol 1998; 17: 283 Google Scholar
Wolff RA, Evans DB, Gravel DM, et al. Phase I trial of gemcitabine combined with radiation for the treatment of locally advanced pancreatic adenocarcinoma. Proc Am Soc Clin Oncol 1998; 17: 283 Google Scholar
Abbruzzese JL, Levin B, Ajani JA, et al. A phase I trial of recombinant human interferon-gamma and recombinant human tumor necrosis factor in patients with gastrointestinal cancer. Cancer Res 1989; 49: 4057–61 PubMedCAS Google Scholar
Abbruzzese JL, Levin B, Ajani JA, et al. A pilot phase II trial of recombinant human interferon-gamma and recombinant human tumor necrosis factor in patients with gastrointestinal malignancies: results of a trial terminated by excessive toxicity. J Biol Response Modif 1992; 9: 522–7 Google Scholar
Andren-Sanderg A, Borg S, Dawiskiba I, et al. Estrogen receptors and estrogen binding protein in pancreatic cancer. Digestion 1982; 25: 12 Google Scholar
Berz C, Hollander C, Miller B. Endocrine responsive pancreatic carcinoma steroid binding and cytotoxicity studies in human tumor cell lines. Cancer Res 1986; 46: 2276–81 Google Scholar
Greenway B, Iqbal MJ, Johnson PJ, et al. Oestrogen receptor proteins in malignant and fetal pancreas. BMJ 1981; 283: 751–3 ArticlePubMedCAS Google Scholar
Satake K, Yoshimoto T, Mukai R, et al. Estrogen receptors in 7,12-dimethylbenz (a) anthracene (DMBA) induced pancreatic carcinoma in rats and in human pancreatic carcinoma. Clin Oncol 1982; 8: 49–54 PubMedCAS Google Scholar
Sandberg AA, Rosenthal HE. Steroid receptors in exocrine glands: the pancreas and prostate. J Steroid Biochem 1979; 11: 293–9 ArticlePubMedCAS Google Scholar
Pousette A, Carlstrom K, Skoldefors H, et al. Purification and partial characterization of a 17β-estradiol-binding macromolecule in the human pancreas. Cancer Res 1982; 42: 633–7 PubMedCAS Google Scholar
Theve NO, Pousette A, Carlstrom K. Adenocarcinoma of the pancreas — a hormone sensitive tumor? A preliminary report on Nolvadex treatment. Clin Oncol 1983; 9: 193–7 PubMedCAS Google Scholar
Wong A, Chan A. Survival benefit of tamoxifen therapy in adenocarcinoma of pancreas.A case-control study. Cancer 1993; 71: 2200–3 ArticlePubMedCAS Google Scholar
Lamberts SWJ, Krenning EP, Reubi JC. The role of somatostatin and its analogs in the diagnosis and treatment of tumors. Endocr Rev 1991; 12: 450–8 ArticlePubMedCAS Google Scholar
Arnold R, Benning R, Neuhaus R, et al. Gastroenteropancreatic endocrine tumors: effect of sandostatin on tumor growth. Digestion 1993; 54 Suppl. 1: 72–5 ArticleCAS Google Scholar
Schally AV. Oncological applications of somatostatin analogues. Cancer Res 1988; 48: 6977–85 PubMedCAS Google Scholar
Johnson LR. Effects of gastrointestinal hormones on pancreatic growth. Cancer 1981; 47: 1640–5 ArticlePubMedCAS Google Scholar
Comaru-Schally M, Schally AV. LH-RH agonists as adjuncts to somatostatin analogs in the treatment of pancreatic cancer. In: Lunefield B, Vickery B, editors. International symposium on Gn-RH analogues in cancer and human reproduction. Boston: Kluwer Academic Publishers, 1990: 203–10 Chapter Google Scholar
Konturek SJ, Bilski J, Jaworek J, et al. Comparison of somatostatin and its highly potent hexa- and octapeptide analogs on exocrine and endocrine pancreatic secretion. Proc Soc Exp Biol Med 1988; 187: 241–9 PubMedCAS Google Scholar
Stoscheck CM, King Jr LE. Role of epidermal growth factor in carcinogenesis. Cancer Res 1986; 46: 1030–7 PubMedCAS Google Scholar
Goustin AS, Leof EB, Shipley GS, et al. Growth factors and cancer. Cancer Res 1986; 46: 1015–29 PubMedCAS Google Scholar
Korc M, Magnum BE. Recycling of epidermal growth factor in a human pancreatic carcinoma cell line. Proc Natl Acad Sci U S A 1985; 82: 6172–5 ArticlePubMedCAS Google Scholar
Lamberts SWJ, Koper JW, Reubi JC. Potential role of somatostatin analogues in the treatment of cancer. Eur J Clin Invest 1987; 17: 281–7 ArticlePubMedCAS Google Scholar
Pollak M, Constantino J, Polychronakos C, et al. Effect of tamoxifen on serum insulinlike growth factor I levels in stage 1 breast cancer patients. J Natl Cancer Inst 1990; 82: 1693–7 ArticlePubMedCAS Google Scholar
Pollak M, Polychronakos C, Guyda H. Somatostatin analogue SMS 201–995 reduces serum IGF levels in patients with neoplasms potentially dependent on IGF-1. Anticancer Res 1989; 9: 889–91 PubMedCAS Google Scholar
Huynh H, Pollak M. Enhancement of tamoxifen-induced suppression of insulin-like growth factor I gene expression and serum level by a somatostatin analogue. Biochem Biophys Res Commun 1994; 203(1): 253–9 ArticlePubMedCAS Google Scholar
Poston GJ, Townsend Jr CM, Rajaraman S, et al. Effect of somatostatin and tamoxifen on the growth of human pancreatic cancers in nude mice. Pancreas 1990; 5: 151–7 ArticlePubMedCAS Google Scholar
Klijn JGM, Hoff AM, Th AS, et al. Treatment of patients with metastatic pancreatic and gastrointestinal tumors with the somatostatin analogue Sandostatin: a phase II study including endocrine effects. Br J Cancer 1990; 62: 627–30 ArticlePubMedCAS Google Scholar
Yamada Y, Post SR, Wang K, et al. Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. Proc Natl Acad Sci U S A 1992; 89: 251–5 ArticlePubMedCAS Google Scholar
Yamada Y, Reisine T, Law S, et al. Somatosustin receptors, an expanding gene family cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase. Mol Endocrinol 1992; 6: 2136–42 ArticlePubMedCAS Google Scholar
Xu Y, Song J, Bruno JF, et al. Molecular cloning and sequencing of a human somatostatin receptor, hSSTR4. Biochem Biophys Res Commun 1993; 193: 648–52 ArticlePubMedCAS Google Scholar
Yamada Y, Kagimoto S, Kubota A, et al. Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and fifth (hSSThS) human somatostatin receptor subtype. Biochem Biophys Res Commun 1993; 195: 844–52 ArticlePubMedCAS Google Scholar
Bell GI, Reisine T. Molecular biology of somatostatin receptors. Trends Neurosci 1993; 16: 34–8 ArticlePubMedCAS Google Scholar
Hoyar D, Bell GI, Berelowitz M, et al. Classification and nomenclature of somatostatin receptors. Trends Pharmacol Sci 1995; 16: 86–8 Article Google Scholar
Buscail L, Delesque N, Esteve J–P, et al. Stimulation of tyrosine phosphatase and inhibition of cell proliferation by somatostatin analogues: mediation by human receptor subtypes SSTR1 and SSTR2. Proc Natl Acad Sci U S A 1994: 91: 2315–9 ArticlePubMedCAS Google Scholar
Buscail L, Esteve J–P, Saint-Laurent N, et al. Inhibition of cell proliferation by the somatostatin analogue RC-160 is mediated by somatostatin receptor subtypes SSTR@ and SSSTR5 through different mechanisms. Proc Natl Acad Sci U S A 1995; 92: 1580–4 ArticlePubMedCAS Google Scholar
Raynor K, Murphy WA, Coy DH, et al. Cloned somatostatin receptors: identification of subtype selective peptides and demonstration of high affinity linear peptides. Mol Pharmacol 1993; 43: 838–44 PubMedCAS Google Scholar
O’Carroll A–M, Raynor K, Lolait SJ, et al. Characterization of cloned human somatostatin receptor SSTR5. Mol Pharmacol 1994; 46: 291–8 PubMed Google Scholar
Patel YC, Srikant CB. Subtype selectivity of peptide analogsfor all five cloned human somatostatin receptors (hsstr 1–5). Endocrinology 1994; 135; 2814–7 ArticlePubMedCAS Google Scholar
Upp JR, Olson D, Poison FJ, et al. Inhibition of growth of two human pancreatic adenocarcinomas in vivo by somatostatin analog SMS 201–995. Am J Surg 1988; 155: 29–35 ArticlePubMedCAS Google Scholar
Liebow C, Reilly C, Serrano M, et al. Somatostatin analogs inhibit growth of pancreatic cancer by stimulating tyrosine phosphatase. Proc Natl Acad Sci U S A 1989; 86: 2003–7 ArticlePubMedCAS Google Scholar
Fisher WE, Boros LG, O’Dorisio MS, et al. Somatostatin receptor status of pancreatic adenocarcinoma predicts response to somatostatin therapy in vitro and in vivo. Surg Forum 1995; 46: 137–40 Google Scholar
Fisher WE, Muscarella P, O’Dorisio TP, et al. Expression of the somatostatin receptor subtype-2 gene predicts response of human pancreatic cancer to octreotide. Surgery 1996; 120: 234–40 ArticlePubMedCAS Google Scholar
Vidal C, Rauly I, Zeggari M, et al. Up-regulation of somatostatin receptors by epidermal growth factor and gastrin in pancreatic cells. Mol Pharmacol 1994; 45: 97–104 Google Scholar
Lamberts SWJ, von Koetsveld P, Hofland LJ. The interrelationship between the antimitotic action of the somatostatin analog octreotide and that of cytostatic drugs and suramin. Int J Cancer 1991; 48: 938–41 ArticlePubMedCAS Google Scholar
Weckbecker G, Raulf F, Tolcsvai L, et al. Potentiation of the anti-proliferative effects of anti-cancer drugs by octreotide in vitro and in vivo. Digestion 1996; 57 Suppl. 1: 22–8 Article Google Scholar
Radulovic S, Nagy A, Szoke B, et al. Cytotoxic analog of somatostatin containing methotrexate inhibits growth of MIA PaCa-2 human pancreatic xenografts in nude mice. Cancer Lett 1992; 62: 263–71 ArticlePubMedCAS Google Scholar
Vennin PH, Peyret JP, Bonneterre J. Effect of the long-acting somatostatin analogue SMS 201–995 in advanced breast cancer. Anticancer Res 1989; 9: 153–6 PubMedCAS Google Scholar
Guliana JM, Guillausseau PJ, Caron J, et al. Effects of short-term subcutaneous administration of SMS 201–995 on calcitonin plasma levels in patients suffering from medullary thyroid carcinoma. Horm Metab Res 1989; 21: 584–6 ArticlePubMedCAS Google Scholar
Kraenzlin ME, Ch’ng JC, Wood SM, et al. Long-term treatment of a VlPoma with somatostatin analogue resulting in remission of symptoms and possible shrinkage of metastases. Gastroenterology 1985; 88: 185–7 PubMedCAS Google Scholar
Parmar H, Bogden A, Mollard M, et al. Somatostatin and somatostatin analogues in oncology. Cancer Treat Rev 1989; 16: 95–115 ArticlePubMedCAS Google Scholar
Morisset J, Genik P, Lord A, et al. Effects of chronic administration of somatostatin on rat exocrine pancreas. Regul Pept 1982; 4: 49–58 ArticlePubMedCAS Google Scholar
Fekete M, Zalatnai A, Comura-Schally AM, et al. Membrane receptors for peptides in experimental and human pancreatic cancers. Pancreas 1989; 4: 521–8 ArticlePubMedCAS Google Scholar
Davies NM, Kapur P, Gillespie J, et al. Inhibitory effect of somatostatin analog RC-160 on EGF- and transforming growth factor alpha (TGF-α)-stimulated pancreatic cancer growth in vivo. Br J Cancer 1991; 64 Suppl. 15: 4 Google Scholar
Schally AV, Srkalovic G, Szende B, et al. Anti-tumor effects of analogs of LH-RH and somatostatin: experimental and clinical studies. J Steroid Biochem Mol Biol 1990; 37: 1061–7 ArticlePubMedCAS Google Scholar
Szende B, Srkalovic G, Schally AV, et al. Inhibitory effects of analogs of luteinizing hormone-releasing hormone and somatostatin on pancreatic cancers in hamsters. Cancer 1990; 65: 2279–90 ArticlePubMedCAS Google Scholar
Paz-Bouza JR, Redding TW, Schally AV. Treatment of nitrosamine-induced pancreatic tumors in hamsters with analogues of somatostatin and luteinizing hormone-releasing hormone. Proc Natl Acad Sci U S A 1987; 84: 1112–6 ArticlePubMedCAS Google Scholar
Szende B, Zalatnai A, Schally AV. Programmed cell death (apoptosis) in pancreatic cancer of hamsters after administration of analogs of luteinizing hormone releasing hormone and somatostatin. Proc Natl Acad Sci U S A 1989; 86: 1643–7 ArticlePubMedCAS Google Scholar
Klijn JGM, Setyono-Han B, Bakker GH, et al. Effects of somatostatin analog (sandostatin) treatment in experimental and human cancer. In: Klijn JGM, Paridaens R, Foekens JA, editors. Hormonal manipulation of cancer: peptides, growth factors and new (anti) steroidal agents. EORTC monograph series, Vol. 19. New York (NY): Raven Press, 1987: 459–68 Google Scholar
Friess H, Buchler M, Beglinger Ch, et al. Low dose octreotide treatment is not effective in patients with advanced pancreatic cancer. Pancreas 1993; 8: 540–5 ArticlePubMedCAS Google Scholar
Frieβ H, Buchler M, Ebert M, et al. Treatment of advanced pancreatic cancer with high dose octreotide. Int J Pancreatol 1993; 14: 290–1 Google Scholar
Ebert M, Frieβ H, Beger H, et al. Role of octreotide in the treatment of pancreatic cancer. Digestion 1994; 55 Suppl. 1: 48–51 Article Google Scholar
Scambia G, Benedetti BP, Baiochhi G, et al. Antiproliferative effects of somatostatin analog SMS 201–995 on three human breast cancer cell lines. J Cancer Res Clin Oncol 1988; 144: 106–8 Google Scholar
Cascinu S, Del Ferro E, Catalano G. A randomized trial of octreotide vs best supportive care only in advanced cancer patients refractory to chemotherapy. Br J Cancer 1995; 71: 97–101 ArticlePubMedCAS Google Scholar
Canobbio L, Boccardo F, Cannata D, et al. Treatment of advanced pancreatic cancer with the somatostatin analogue BIM 23014. Cancer 1992; 69: 648–50 ArticlePubMedCAS Google Scholar
Huguier M, Samama G, Testart J,, et al. Treatment of adenocarcinoma of the pancreas with somatostatin and gonadoliberin (luteinizing hormone-releasing hormone). Am J Surg 1992; 164: 348–53 ArticlePubMedCAS Google Scholar
Weckbecker G, Tolcsvai L, Stolz B, et al. Somatostatin analogue octreotide enhances the antineoplastic effects of tamoxifen and ovariectomy on 7,12-dimethylbenz(a)anthracene-induced rat mammary carcinomas. Cancer Res 54: 6334-7
Rosenberg L, Barkun AN, Denis MH, et al. Low-dose octreotide and tamoxifen in the treatment of adenocarcinoma of the pancreas. Cancer 1995; 75: 23–8 ArticlePubMedCAS Google Scholar
Fazeny B, Baur M, Prohaska M, et al. Octreotide combined with goserelin in the therapy of advanced pancreatic cancer: results of a pilot study and review of the literature. J Cancer Res Clin Oncol 1997; 123: 45–52 ArticlePubMedCAS Google Scholar
Corbishley TP, Iqbal MJ, Wilkinson ML, et al. Androgen receptor in human normal and malignant pancreatic tissue and cell lines. Cancer 1986; 57: 1992–5 ArticlePubMedCAS Google Scholar
Iqbal MJ, Greenway BA, Wilkinson WL, et al. Sex steroid enzymes, aromatase and 5α reductase in the pancreas: a comparison of normal adult, foetal and malignant tissue. Clin Sci 1983; 65: 71–5 PubMedCAS Google Scholar
Greenway BA, Duke D, Pym B, et al. The control of human pancreatic adenocarcinoma xenografts in nude mice by hormone therapy. Br J Surg 1982; 69: 595–7 ArticlePubMedCAS Google Scholar
Greenway BA. Effect of flutamide on survival in patients with pancreatic cancer: results of a prospective, randomised, double blind, placebo controlled trial. BMJ 1998; 316: 1935–8 ArticlePubMedCAS Google Scholar
Ryan DP, Fuchs C. Chemotherapy for pancreatic cancer. Adv Oncol 1998; 14: 11–9 Google Scholar
Gibbs JB, Oliff A, Kohl NE. Farnesyltransferase inhibitors: ras research yields a potential cancer therapeutic. Cell 1994; 77: 175–8 ArticlePubMedCAS Google Scholar
Kawa S, Nikaido T, Aoki Y, et al. Arotinoid mofarotene (R040-8757) up-regulates p21 and p27 during growth inhibition of pancreatic cancer cell lines. Int J Cancer 1997; 72: 906–11 ArticlePubMedCAS Google Scholar
Joshhi US, Dergham ST, Chen YQ, et al. Inhibition of pancreatic tumour cell growth in culture by p21 WAF1 recombinant adenovirus. Pancreas 1998; 16: 107–13 Article Google Scholar
Dergham ST, Dugan MC, Joshi US, et al. The clinical significance of p21WAF1/CIP-1 and p53 expression in pancreatic adenocarcinoma. Cancer 1997; 80: 372–81 ArticlePubMedCAS Google Scholar
Joshi US, Dergham ST, Chen YQ, et al. Inhibition of pancreatic tumor cell growth in culture by p21WAF1 recombinant adenovirus. Pancreas 1998; 16: 107–13 ArticlePubMedCAS Google Scholar
Mohammad RM, Dugan MC, Mohamed AN, et al. Establishment of human pancreatic tumor xenograft model: potential application for preclinical evaluation of novel therapeutic agents. Pancreas 1998; 16: 19–25 ArticlePubMedCAS Google Scholar
Lee JH, Federoff HJ, Schoeniger LO, et al. G207, modified herpes simplex virus type 1, kills human pancreatic cancer cells in vitro. J Gastrointest Surg 1999; 3: 127–33 ArticlePubMedCAS Google Scholar
Mineta T, Rabkin SD, Yazaki T, et al. Attenuated multi-mutated herpes simplex virus-1 for the treatment of malignant gliomas. Nat Med 1995; 1: 938–43 ArticlePubMedCAS Google Scholar
Yazaki T, Manz HJ, Rabkins SD, et al. Treatment of human malignant meningiomas by G207, a replication-competent multimutated herpes simplex virus 1. Cancer Res 1995; 55: 4752–6 PubMedCAS Google Scholar
Link Jr CJ, Levy LP, McCann LZ, et al. Gene therapy for colon cancer with the herpes simplex thymidine kinase gene. J Surg Oncol 1997; 64: 289–94 ArticlePubMedCAS Google Scholar
Yeo C. Pancreatic cancer: 1998 update. J Am Coll Surg 1998; 187: 429–42 PubMedCAS Google Scholar
Clary BM, Coveney EC, Blazer DG, et al. Active immunotherapy of pancreatic cancer with tumor cells genetically engineered to secrete multiple cytokines. Surgery 1996; 120: 174–81 ArticlePubMedCAS Google Scholar
Simons JW, Jalfee EM, Weber C, et al. Bioactivity of human GM-CSF gene transduced autologous renal vaccines. Cancer Res 1997; 57: 1537–46 PubMedCAS Google Scholar
Cheson BD, Phillips PH, Sanol M. National Cancer Institute. Clinical trials. Oncology 1997; 11: 81–90 CAS Google Scholar
Jaffee EM, Schutte M, Gossett J, et al. Development and characterization of cytokine-secreting pancreatic adenocarcinoma vaccine from primary tumors for use in clinical trials. Cancer J Sci Am 1998; 4: 194–203 PubMedCAS Google Scholar
Friess H, Gassmann M, Buchler MW. Adjuvant therapy of pancreatic cancer using monoclonal antibodies and immune response modifiers. Int J Pancreatol 1997; 11: 43–52 Google Scholar
Sears HF, Steplewski Z, Herlyn D, et al. Effects of monoclonal antibody immunotherapy on patients with gastrointestinal adenocarcinoma. J Biol Resp Mod 1984; 3: 138–50 CAS Google Scholar
Adams DO, Hall T, Steplewski Z, et al. Tumors undergoing regression induced by monoclonal antibodies of the IgG2a isotype contain increased numbers of macrophages activated for a distinctive form of antibodycytolysis. Proc Natl Acad Sci U S A 1984: 81: 3506–10 ArticlePubMedCAS Google Scholar
Tempero MA, Pour PM, Uchida E, et al. Monoclonal antibody CO 17-1A and leukopheresis in immunotherapy of pancreatic cancer. Hybridoma 1986; 5 Suppl. 1: 133–8 Google Scholar
Sindelar WF, Maher MM, Herlyn D, et al. Trial of therapy with monoclonal antibody 17-1A in pancreatic carcinoma: preliminary results. Hybridoma 1986; 5 Suppl. 1: 125–32 Google Scholar
Tempero MA, Sivinski CL, Steplewski Z, et al. Phase II trial of gamma interferon and monoclonal antibody 17-1A in pancreatic cancer: biological and clinical effects. J Clin Oncol 1990; 8: 2019–26 PubMedCAS Google Scholar
Tempero MA, Haga Y, Sivinski C, et al. Immunotherapy with monoclonal antibody (MAB) in pancreatic adenocarcinoma. Int J Pancreatol 1991; 9: 125–34 PubMedCAS Google Scholar
Weiner LM, Haney F, Padavic-Shaller K, et al. Phase II multicenter evaluation of prolonged murine monoclonal antibody 17-1A therapy in pancreatic carcinoma. J Immunother 1993; 13: 110–6 ArticleCAS Google Scholar
Bosslet K, Kern HF, Kanzy FJ, et al. A monoclonal antibody with binding and inhibiting activity towards human pancreatic carcinoma cells. I: Immunohistological and immunochemical characterization of a murine monoclonal antibody selecting for well differentiated adenocarcinomas of the pancreas. Cancer Jmmunol Immunother 1986; 23: 185–91 CAS Google Scholar
Kubel R, Buchler M, Baczako K, et al. Immunohistochemistry in pancreatic cancer with new monoclonal antibodies. Lang Arch Chir 1987; 371: 243–52 ArticleCAS Google Scholar
Montz R, Klapdor R, Rothe B, et al. Immunoscintigraphy and radioimmunotherapy in patients with pancreatic carcinoma. Nuklearmedizin 1986; 25: 239–44 PubMedCAS Google Scholar
Kern HF, Bosslet K, Mollenhatter J, et al. Monocyte-related functions expressed in cell lines established from human pancreatic adenocarcinoma. I. Comparative analysis of endocytotic activity, lysosomal enzyme secretion, and Superoxide anion production. Pancreas 1987; 2: 212–21 CAS Google Scholar
Kern HF, Bosslet K, Sedlacek HH, et al. Monocyte-related functions expressed in cell lines established from human pancreatic adenocarcinoma. II. Inhibition of stimulated activity by monoclonal antibodies reacting with surface antigens on tumor cells. Pancreas 1988; 3: 2–10 CAS Google Scholar
Klapdor R, Lander S, Bahlo M, et al. Radioimmunotherapy of xenografts of human pancreatic carcinomas intravenous and intratumoral application of 131I-labeled monoclonal antibodies. Nuklearmedizin 1986; 25: 235–8 PubMedCAS Google Scholar
Buchler M, Kubel R, Malfertheiner P, et al. Immunotherapy of advanced pancreatic carcinoma with the monoclonal antibody BW 494. Dtsch Med Wochenschr 1988; 113: 374–80 ArticlePubMedCAS Google Scholar
Buchler NI, Friess H, Malfertheiner P, et al. Studies of pancreatic cancer utilizing monoclonal antibodies. Int J Pancreatol 1990; 7: 151–7 PubMedCAS Google Scholar
Buchler M, Friess H, Schultheiss KH, et al. A randomized controlled trial of adjuvant immunotherapy (murine monoclonal antibody 494i32) in resectable pancreatic cancer. Cancer 1991; 68: 1507–12 ArticlePubMedCAS Google Scholar
Buchler M, Kubel R, Klapdor R, et al. Immunotherapy of pancreatic cancer with monoclonal antibody BW 494: results from a multicentric phase I-II trial. In: Beger HG, Buehler M, Schulz G, et al., editors. Cancer therapy. Berlin: Springer. 1989: 3241 Google Scholar
Friess H, Buchler M, Schulz G, et al. Therapy of pancreatic carcinoma with the monoclonal antibody BW494/32: first clinical results. Immunitat Infekt 1989; 17: 2–26 Google Scholar
Bosslet K, Keweloh HC, Hermentin P, et al. Percolation and binding of monoclonal antibody BW494 to pancreatic carcinoma tissues during high dose immunotherapy and consequences for future therapy modalities. Br J Cancer 1990; 10: 37–9 CAS Google Scholar
Goodman GE, Hellstrom I, Yelton D, et al. Phase I trial of chimeric (human-mouse) monoclonal antibody L6 in patients with non-small-cell lung. colon. and breast cancer. Cancer Immunol Immunother 1993: 36: 267–73 ArticlePubMedCAS Google Scholar
Kushner BH, Cheung NK. GM-CSF enhances 3F8 monoclonal antibody-dependent cellular cytotoxicity against human melanoma and neuroblastoma. Blood 1989; 73: 1936–41 PubMedCAS Google Scholar
Senter PD. Activation of prodrugs by antibody-enzyme conjugates: a new approach to cancer therapy. FASEB J 1990: 4: 188–93 PubMedCAS Google Scholar
Svensson HP, Kadow JF, Vrudhula VM, et al. Monoclonal antibody-beta-lactamase conjugates for the activation of a cephalosporin mustard prodrug. Bioconjug Chem 1992;3: 176–81 ArticlePubMedCAS Google Scholar
Senter PD, Wallace PM, Svensson HP, et al. Activation of prodrugs by antibody-enzyme conjugates. Adv Exp Med Biol 1991; 303: 97–105 ArticlePubMedCAS Google Scholar
Stalb F, Link KH, Mitchell MS. Immunomodulation of pancreatic cancer in vitro. Effect of monoclonal antibodies, GM-CSF and lymphokine-activated killer cells. Digestion 1992: 52: 124 Google Scholar
Butera J, Malachovsky M, Rathore R, et al. Novel approaches in development for the treatment of pancreatic cancer. Front Biosci 1998; 3: E226–9 PubMedCAS Google Scholar
Nagakawa T, Konishi I, Higashino Y, et al. The spread and prognosis of carcinoma in the region of the pancreatic head. Jpn J Surg 1989; 19: 510–8 ArticlePubMedCAS Google Scholar
Nagakawa T, Kavahara M, Ueno K, et al. A clinicopathologic study on neural invasion in cancer of the pancreatic bead. Cancer 1992; 69: 930–5 ArticlePubMedCAS Google Scholar
Mollenhauer J, Roether 1, Kern HF. Distribution of extracellular matrix proteins in pancreatic ductal adenocarcinoma and its influence on tumor cell proliferation in vitro. Pancreas 1987; 2: 14–24 ArticlePubMedCAS Google Scholar
Bramhall SR. The matrix metalloproteinases and their inhibitors in pancreatic cancer. Int J Pancreatol 1997; 21: 1–12 PubMedCAS Google Scholar
Hart IR, Goode NT, Wilson RE. Molecular aspects of the metastatic cascade. Biochem Biophys Acta 1989; 989: 65–84 PubMedCAS Google Scholar
Liotta LA, Tryggvason K, Garbisa S, et al. Metastatic potential correlates with enzymatic degradation of basement membrane collagen. Nature 1980; 284: 67–8 ArticlePubMedCAS Google Scholar
Liotta LA, Stetler-Stevenson WG. Tumor invasion and metastasis: an imbalance of positive and negative regulation. Cancer Res 1991; 51 Suppl.: 5054–9s Google Scholar
Martinez-Hernandez A, Amenta PS. The basement membrane in pathology. Lab Invest 1983; 48: 650–77 Google Scholar
Forster SJ, Talbot IC, Clayton DG, et al. Tumour basement membrane laminin in adenocarcinoma of rectum: an immuno-histochemical study of biological andclinical significance. Int J Cancer 1986; 37: 813–7 ArticlePubMedCAS Google Scholar
Charpin C, Lissitzky JC, Jacquemier J, et al. Immunohisto-chemical detection of laminin in 98 human breast carcinomas: a light and electron microscopic study. Hum Pathol 1986; 17: 355–65 ArticlePubMedCAS Google Scholar
Lee CS, Montebello J, Georgiou T, et al. Distribution of type IV collagen in pancreatic adenocarcinoma and chronic pancreatitis. Int J Exp Pathol 1994; 75: 79–83 PubMedCAS Google Scholar
Wang Z-h, Manabe T, Ohshio C, et al. Immunohistochemical study of heparan sulfate proteoglycan in adenocarcinomas of the pancreas. Pancreas 1994; 9: 758–63 ArticlePubMedCAS Google Scholar
Cottam DW, Rees RC. Regulation of matrix metalloproteinases: their role in tumor invasion and metastasis (review). Int J Oncol 1993; 2: 861–72 PubMedCAS Google Scholar
Docherty AJ, Murphy C. The tissue metalloproteinase family and the inhibitor TIMP: a study using cDNAs and recombinant proteins. Ann Rheum Dis 1990; 49: 469–79 PubMed Google Scholar
Brown T, Tangen C, Fleming T, et al. A phase II trial of taxol and granulocyte colony stimulating factor (G-CSF) in patients with adenocarcinoma of the pancreas. Proc Am Soc Clin Oncol 1993; 12: 200 Google Scholar
Kaue SB. Docetaxel (taxotere) in the treatment of solid tumors other than breast and lung cancer. Semin Oncol 1995; 22(4): 30–3 Google Scholar
Rougier D, DeForin M, Ademis A, et al. Phase II study of taxotere in pancreatic adenocarcinoma. Proc Am Soc Clin Oncol 1994; 13: 200 Google Scholar
Stehlin JS, Giovanella BC, Natelson EA, et al. A study of 9-nitrocamptothecin (RFS-2000) in patients with advanced pancreatic cancer. Int J Oncol 1999; 14: 821–31 PubMedCAS Google Scholar
Harris AL. Anti-angiogenesis therapy and strategies for integrating it with adjuvant therapy. Recent Results Cancer Res 1998; 152: 341–52 ArticlePubMedCAS Google Scholar