Anticytokine Therapy for Osteoarthritis (original) (raw)

• Goldring MB. Anticytokine therapy for osteoarthritis. Expert Opin Biol Ther 2001; 1(5): 817–29
  Article PubMed CAS Google Scholar
• Fernandes JC, Martel-Pelletier J, Pelletier J-P. The role of cytokines in osteoarthritis pathophysiology. Biorheology 2002; 39(1–2): 237–46
  PubMed CAS Google Scholar
• Malemud CJ. Cytokines as therapeutic targets for osteoarthritis. Biodrugs 2004; 18(1): 23–35
  Article PubMed CAS Google Scholar
• Blom AB, van der Kraan PM, van den Berg WB. Cytokine targeting in osteoarthritis. Curr Drug Targets 2007; 8(2): 283–92
  Article PubMed CAS Google Scholar
• Martel-Pelletier J, Pelletier J-P. Inflammatory factors involved in osteoarthritis. In: Buckwalter JA, Lotz M, Stoltz J-F, editors. Osteoarthritis, inflammation and degradation: a continuum. Amsterdam: IOS Press, 2007: 3–13
  Google Scholar
• Otero M, Lago R, Gómez R, et al. Leptin, a metabolic hormone that functions as a proinflammatory adipokine. Drug New Prospect 2006; 19(1): 21–6
  Article CAS Google Scholar
• Saklatvala J. Inflammatory signalling in cartilage: MAPK and NF-κB pathways in chondrocytes and the use of inhibitors for research into the pathogenesis and therapy of osteoarthritis. Curr Drug Targets 2007; 8(2): 305–13
  Article PubMed CAS Google Scholar
• Fan Z, Söder S, Oehler S, et al. Activation of interleukin-1 signaling cascades and osteoarthritic cartilage. Am J Pathol 2007; 171(3): 938–46
  Article PubMed CAS Google Scholar
• Pujol J-P, Chadjichristos C, Legendre F, et al. Interleukin-1 and transforming growth factor-β1 as crucial factors in osteoarthritic cartilage metabolism. Connect Tissue Res 2008; 49(3): 293–7
  Article PubMed CAS Google Scholar
• Corr M. Wnt-beta-catenin signaling in the pathogenesis of osteoarthritis. Nat Clin Pract Rheumatol 2008; 4(10): 550–6
  Article PubMed CAS Google Scholar
• Morales TI. The quantitative and functional relation between insulin-like growth factor-1 (IGF) and IGF-binding proteins during human osteoarthritis. J Orthop Res 2008; 26(4): 465–74
  Article PubMed CAS Google Scholar
• Goldring MB, Otero M, Tsuchimochi K, et al. Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism. Ann Rheum Dis 2008; 67Suppl. 3: iii75-82
  Article PubMed CAS Google Scholar
• Verbruggen G. Chondroprotective drugs in degenerative joint diseases. Rheumatology (Oxford) 2006; 45(2): 129–38
  Article CAS Google Scholar
• Tincani A, Andreoli L, Bazzani C, et al. Inflammatory molecules: a target for treatment in systemic autoimmune diseases. Autoimmun Rev 2007; 7(1): 1–7
  Article PubMed CAS Google Scholar
• Sizova L. Approaches to the treatment of early rheumatoid arthritis with disease-modifying antirheumatic drugs. Br J Clin Pharmacol 2008; 66(2): 173–8
  Article PubMed CAS Google Scholar
• Alonso-Ruiz A, Pijoan JI, Ansuategui E, et al. Tumor necrosis factor alpha drugs in rheumatoid arthritis: systemic review and metaanalysis of efficacy and safety. BMC Musculoskel Disord 2008; 9: 52
  Article Google Scholar
• Tayal V, Kaira BS. Cytokines and anti-cytokines as therapeutics: an update. Eur J Pharmacol 2008; 579(1–3): 1–12
  Article PubMed CAS Google Scholar
• Daheshia M, Yao JQ. The interleukin 1b pathway in the pathogenesis of osteoarthritis. J Rheumatol 2008; 35(12): 2306–12
  Article PubMed CAS Google Scholar
• Glasson SS. In vivo osteoarthritis target validation using genetically-modified mice. Curr Drug Targets 2007; 8(2): 367–76
  Article PubMed CAS Google Scholar
• Chen LX, Lin X, Wang HJ, et al. Suppression of early experimental osteoarthritis by in vivo delivery of the adenoviral vector-mediated NF-κB65-specific siRNA. Osteoarthritis Cartilage 2008; 16(2): 174–84
  Article PubMed CAS Google Scholar
• Huebner JL, Selfer DR, Kraus VB. A longitudinal analysis of serum cytokines in the Hartley guinea pig model of osteoarthritis. Osteoarthritis Cartilage 2007; 15(3): 354–6
  Article PubMed CAS Google Scholar
• Ley C, Ekman S, Elmén A, et al. Interleukin-6 and tumour necrosis factor in synovial fluid from horses with carpal joint pathology. J Vet Med A Physiol Pathol Clin Med 2007; 54(7): 346–51
  Article PubMed CAS Google Scholar
• Maccoux LJ, Salway F, Day PJ, et al. Expression profiling of select cytokines in canine osteoarthritis tissues. Vet Immunol Immunopathol 2007; 118(1–2): 59–67
  Article PubMed CAS Google Scholar
• Bondeson J, Wainwright SD, Lauder S, et al. The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis. Arthritis Res Ther 2006; 8(6): R187
  Article PubMed CAS Google Scholar
• Doss F, Menard J, Hauschild N, et al. Elevated IL-6 levels in the synovial fluid of osteoarthritis patients stem from plasma cells. Scand J Rheumatol 2007; 36(2): 136–9
  Article PubMed CAS Google Scholar
• Kobayashi M, Squires GR, Mousa A, et al. Role of interleukin-1 and tumor necrosis factor α in matrix degradation of human osteoarthritic cartilage. Arthritis Rheum 2005; 52(1): 128–35
  Article PubMed CAS Google Scholar
• Burger D, Dayer J-M, Palmer G, et al. Is IL-1 a good therapeutic target in the treatment of arthritis? Best Pract Res Clin Rheumatol 2006; 20(5): 879–96
  Article PubMed CAS Google Scholar
• Goupille P, Mulleman D, Chevalier X. Is interleukin 1 a good target for therapeutic intervention in intervertebral disc degeneration: lessons for the osteoarthritic experience. Arthritis Res Ther 2007; 9(6): 110
  Article PubMed CAS Google Scholar
• Iqbal I, Fleischmann R. Treatment of osteoarthritis with anakinra. Curr Rheumatol Rep 2007; 9(1): 31–5
  Article PubMed CAS Google Scholar
• Chevalier X, Giraudeau B, Conrozier T, et al. Safety study of intraarticular injection of interleukin 1 receptor antagonist in patients with painful knee osteoarthritis: a multicenter study. J Rheumatol 2005; 32(7): 1317–23
  PubMed CAS Google Scholar
• Chevalier X, Goupille P, Beaulieu AD, et al. Intraarticular injection of anakinra in osteoarthritis of the knee: a multicenter, randomized, double-blind placebo-controlled trial. Arthritis Rheum 2009; 61(3): 344–52
  Article PubMed CAS Google Scholar
• Yang KG, Raijmakers NJ, van Arkel ER, et al. Autologous interleukin-1 receptor antagonist improves function and symptoms in osteoarthritis when compared to placebo in a prospective randomized controlled trial. Osteoarthritis Cartilage 2008; 16(4): 498–505
  Article PubMed Google Scholar
• Richette P, François M, Vicaut E, et al. A high interleukin 1 receptor anatagonist/IL-1b ratio occurs naturally in knee osteoarthritis. J Rheumatol 2008; 35(8): 1650–4
  PubMed CAS Google Scholar
• Lequesne MG. The algofunctional indices for hip and knee osteoarthritis. J Rheumatol 1997; 24(4): 779–81
  PubMed CAS Google Scholar
• Miyaki S, Nakasa T, Otsuki S, et al. MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses. Arthritis Rheum 2009; 60(9): 2723–30
  Article PubMed CAS Google Scholar
• Tetlow LC, Adlam DJ, Woolley DE. Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritis cartilage: associations with degenerative changes. Arthritis Rheum 2001; 44(3): 585–94
  Article PubMed CAS Google Scholar
• Wu W, Billinghurst RC, Pidoux I, et al. Sites of collagenase cleavage and denaturation of type II collagen in aging and osteoarthritic articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 and matrix metalloproteinase 13. Arthritis Rheum 2002; 46(8): 2087–94
  Article PubMed CAS Google Scholar
• Brandt KD, Dieppe P, Radin E. Etiopathogenesis of osteoarthritis. Med Clin North Am 2009; 93(1): 1–24, xv
  Article PubMed Google Scholar
• Denko CW, Malemud CJ. Metabolic disturbances and synovial membrane responses in osteoarthritis. Front Biosci 1999; 4: D686–93
  PubMed CAS Google Scholar
• Denko CW, Malemud CJ. Role of the growth hormone/insulin-like growth factor-1 paracrine axis in rheumatic diseases. Semin Arthritis Rheum 2005; 35(1): 24–34
  Article PubMed CAS Google Scholar
• Patel IR, Attur MG, Patel RN, et al. TNF-α convertase enzyme from human arthritis-affected cartilage: isolation of cDNA by differential display, expression of the active enzyme, and regulation of TNF-α. J Immunol 1998; 160(9): 4570–9
  PubMed CAS Google Scholar
• Skotnicki JS, DiGrandi MJ, Levin JI. Design strategies for the identification of MMP-13 and TACE inhibitors. Curr Opin Drug Discov Devel 2003; 6(5): 742–59
  PubMed CAS Google Scholar
• Levin JI. The design and synthesis of aryl hydroxamic acid inhibitors of MMPs and TACE. Curr Top Med Chem 2004; 4(12): 1289–310
  Article PubMed CAS Google Scholar
• Pelletier J-P, Martel-Pelletier J, Malemud CJ. Effects of non-steroidal anti-inflammatory drugs and corticosteroids on cartilage metabolism in rheumatoid arthritis and osteoarthritis. In: Lewis AJ, Furst DE, editors. Non-steroidal anti-inflammatory drugs: mechanisms and clinical uses. 2nd ed. New York: Marcel Dekker, 1994: 5–25
  Google Scholar
• Hochberg MC, Dougados M. Pharmacological therapy of osteoarthritis. Best Pract Res Clin Rheumatol 2001; 15(4) 583–93
  Article PubMed CAS Google Scholar
• Petrella RJ, Petrella M. A prospective, randomized, double-blind, placebo controlled study to evaluate the efficacy of intraarticular hyaluronic acid for osteoarthritis of the knee. J Rheumatol 2006; 33(5): 951–6
  PubMed CAS Google Scholar
• Brzusek D, Petron D. Treating knee osteoarthritis with intra-articular hyaluronans. Curr Med Res Opin 2008; 24(12): 3307–22
  Article PubMed CAS Google Scholar
• Schnitzer TJ, Weaver AL, Polis AB, et al. Efficacy of rofecoxib, celecoxib, and acetaminophen in patients with osteoarthritis of the knee: a combined analysis of the VACT studies. J Rheumatol 2005; 32(6): 1093–105
  PubMed CAS Google Scholar
• Singh G, Fort JG, Goldstein JL, et al. Celecoxib versus naproxen and diclofenac in osteoarthritis patients: SUCCESS-I study. Am J Med 2006; 1993(3): 255–66
  Article CAS Google Scholar
• Becker MC, Wang TH, Wisniewski L, et al. Rationale, design and governance of Prospective Randomized Evaluation of Celecoxib Integrated Safety versus Ibuprofen or Naproxen (PRECISION), a cardiovascular end point trial of nonsteroidal anti-inflammatory agents in patients with arthritis. Am Heart J 2009; 157(4): 606–12
  Article PubMed CAS Google Scholar
• Curtis SP, Bockow B, Fisher C, et al. Etoricoxib in the treatment of osteoarthritis over 52-weeks: a double blind, active comparator controlled trial [NCT00242489]. BMC Musculoskelet Disord 2005; 6: 58
  Article PubMed CAS Google Scholar
• Reginster JY, Malmstrom K, Mehta A, et al. Evaluation of the efficacy and safety of etoricoxib compared with naproxen in 2, 138-week randomised studies of patients with osteoarthritis. Ann Rheum Dis 2007; 66(7): 945–51
  Article PubMed CAS Google Scholar
• Dahlberg LE, Holme I, Høye K, et al. A randomised, multicentre, double-blind, parallel-group study to assess adverse event-related discontinuation rate with celecoxib and diclofenac in elderly patients with osteoarthritis. Scand J Rheumatol 2009; 38(2): 133–43
  Article PubMed CAS Google Scholar
• Mastbergen SC, Bijlsma JW, Lafeber FP. Selective COX-2 inhibition is favorable to human early and late-stage osteoarthritic cartilage: a human in vitro study. Osteoarthritis Cartilage 2005; 13(6): 519–26
  Article PubMed CAS Google Scholar
• Mastbergen SC, Marijnissen AC, Vianen ME, et al. Inhibition by celecoxib in the canine groove model of osteoarthritis. Rheumatology (Oxford) 2006; 45(4): 405–13
  Article CAS Google Scholar
• Bottone FG, Barry WT. Postmarketing surveillance of serious adverse events associated with the use of rofecoxib from 1999–2002. Curr Med Res Opin 2009; 25(6): 1535–50
  Article PubMed CAS Google Scholar
• Jeffrey JE, Aspden RM. Cyclooxygenase inhibition lowers prostaglandin E2 release from articular cartilage and reduces apoptosis but not proteoglycan degradation following an impact load in vitro. Arthritis Res Ther 2007; 9(6): R129
  Article PubMed CAS Google Scholar
• Malemud CJ, Gillespie HJ. The role of apoptosis in arthritis. Curr Rheum Rev 2005; 1(2): 131–42
  Article CAS Google Scholar
• Del Carlo Jr M, Loeser RF. Cell death in osteoarthritis. Curr Rheumatol Rep 2008; 10(1): 37–42
  Article PubMed Google Scholar
• Weng LH, Wang CJ, Ko JY, et al. Inflammation induction of Dickkopf-1 mediates chondrocyte apoptosis in osteoarthritic joint. Osteoarthritis Cartilage 2009; 17(7): 919–29
  Article Google Scholar
• Burrage PS, Mix KS, Brinckerhoff CE. Matrix metalloproteinases: role in arthritis. Front Biosci 2006; 11: 529–43
  Article PubMed CAS Google Scholar
• Gupta K, Shukla M, Cowland JB, et al. Neutrophil-gela-tinase-associated lipocalin is expressed in osteoarthritis and forms a complex with matrix metalloproteinase-9. Arthritis Rheum 2007; 56(10): 3326–35
  Article PubMed CAS Google Scholar
• Jackson MT, Smith MM, Smith SM, et al. Activation of cartilage matrix metalloproteinases by activated protein C. Arthritis Rheum 2009; 60(3): 780–91
  Article PubMed CAS Google Scholar
• Fosang AJ, Little CB. Drug insight: aggrecanases as therapeutic targets for osteoarthritis. Nat Clin Pract Rheumatol 2008; 4(8): 420–7
  Article PubMed CAS Google Scholar
• Bondeson J, Wainwright S, Hughes C, et al. The regulation of ADAMTS4 and ADAMTS5 aggrecanases in osteoarthritis: a review. Clin Exp Rheumatol 2008; 26(1): 139–45
  PubMed CAS Google Scholar
• Malemud CJ, Islam N, Haqqi TM. Pathophysiological mechanisms in osteoarthritis lead to novel therapeutic strategies. Cells Tissues Organs 2003; 174(1–2): 34–48
  Article PubMed Google Scholar
• Aigner T, Sachse A, Gebhard A, et al. Osteoarthritis: pathobiology-targets and ways for therapeutic intervention. Adv Drug Deliv Rev 2006; 58(2): 128–49
  Article PubMed CAS Google Scholar
• Malemud CJ, Schulte ME. Is there a final common pathway for arthritis? Future Rheumatol 2008; 3(3): 253–68
  Article CAS Google Scholar
• Chen FH, Tuan RS. Mesenchymal stem cells in arthritic diseases. Arthritis Res Ther 2008; 10(5): 223
  Article PubMed CAS Google Scholar
• Abramson SB, Attur M. Developments in the scientific understanding of osteoarthritis. Arthritis Res Ther 2009; 11(3): 227
  Article PubMed Google Scholar
• Koelling S, Kruegel J, Irmer M, et al. Migratory chondrogenic progenitor cells from repair tissue during the later stages of human osteoarthritis. Cell Stem Cell 2009; 4(4): 324–35
  Article PubMed CAS Google Scholar
• Zaslav K, Cole B, Brewster R, et al. A prospective study of autologous chondrocyte implantation in patients with failed prior treatment for articular cartilage defect of the knee: results of the Study of the Treatment of Articular Repair (STAR) clinical trial. Am J Sports Med 2009; 37(1): 42–55
  Article PubMed Google Scholar
• Goldring SR. Role of bone in osteoarthritis pathogenesis. Med Clin North Am 2009; 93(1): 25–35, xv
  Article PubMed Google Scholar
• Sawitzke AD, Shi H, Finco MF, et al. The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis: a report from the Glucosamine/Chondroitin Arthritis Intervention Trial. Arthritis Rheum 2008; 58(10): 3183–91
  Article PubMed CAS Google Scholar
• Bruyere O, Reginster JY. Glucosamine and chondroitin sulfate as therapeutic agents for knee and hip osteoarthritis. Drugs Aging 2007; 24(7): 573–80
  Article PubMed CAS Google Scholar
• Huskison EC. Glucosamine and chondroitin for osteoarthritis. J Int Med Res 2008; 36(6): 1161–79
  Google Scholar
• Uebelhart D. Clinical review of chondroitin sulfate in osteoarthritis. Osteoarthritis Cartilage 2008; 16Suppl. 3: S19–21
  Article PubMed Google Scholar
• Martin JA, Buckwalter JA. Aging, articular cartilage chondrocyte senescence and osteoarthritis. Biogerontology 2002; 3(5): 257–64
  Article PubMed CAS Google Scholar
• Valdes AM, Spector TD. The contribution of genes to osteoarthritis. Med Clin North Am 2009; 93(1): 45–66, x
  Article PubMed CAS Google Scholar
• Yasuda T. Cartilage destruction by matrix degradation products. Mod Rheumatol 2006; 16(4): 197–205
  Article PubMed CAS Google Scholar
• Sakao K, Takahashi KA, Mazda O, et al. Enhanced expression of interleukin-6, matrix metalloproteinase-13, and receptor activator of NF-KB ligand in cells derived from osteoarthritic subchondral bone. J Orthop Sci 2008; 13(3): 202–10
  Article PubMed CAS Google Scholar
• Livshits G, Zhai G, Hart DJ, et al. Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: the Chingford study. Arthritis Rheum 2009; 60(7): 2037–45
  Article PubMed CAS Google Scholar
• Pola E, Papaleo P, Pola R, et al. Interleukin-6 gene polymorphism and risk of osteoarthritis of the hip: a case-control study. Osteoarthritis Cartilage 2005; 13(11): 1025–8
  Article PubMed CAS Google Scholar
• de Hooge AS, van de Loo FA, Bennink MB, et al. Male IL-6 gene knock out mice developed more advanced osteoarthritis upon aging. Osteoarthritis Cartilage 2005; 13(1): 66–73
  Article PubMed Google Scholar
• Nile CJ, Read RC, Akil M, et al. Methylation status of a single CpG site in the IL6 promoter is related to IL6 messenger RNA levels and rheumatoid arthritis. Arthritis Rheum 2008; 58(9): 2686–93
  Article PubMed Google Scholar
• Pretzel D, Pohlers D, Weinert S, et al. In vitro model for the analysis of synovial fibroblast-mediated degradation of intact cartilage. Arthritis Res Ther 2009; 11(1): R25
  Article PubMed CAS Google Scholar
• Pulai JI, Chen H, Im HJ, et al. NF-κB mediates the stimulation of cytokine and chemokine expression by human articular chondrocytes in response to fibronectin fragments. J Immunol 2005; 174(9): 5781–8
  PubMed CAS Google Scholar
• Stanton H, Ung L, Fosang AJ. The 45 kDa collagen-binding fragment of fibronectin induces matrix metalloproteinase-13 synthesis by chondrocytes and aggrecan degradation by aggrecanases. Biochem J 2002; 364 (Pt 1): 181–90
  PubMed CAS Google Scholar
• Klatt AR, Paul-Klausch B, Klinger G, et al. A critical role for collagen II in cartilage matrix degradation: collagen II induces pro-inflammatory cytokines and MMPs in primary human chondrocytes. J Orthop Res 2009; 27(1): 65–70
  Article PubMed CAS Google Scholar
• Klatt AR, Zech D, Kühn G, et al. Discoidin domain receptor 2 mediates the collagen II-dependent release of interleukin-6 in primary human chondrocytes. J Pathol 2009; 218(2): 241–7
  Article PubMed CAS Google Scholar
• Porée B, Kypriotou M, Chadjichristos C, et al. Interleukin-6 (IL-6) and soluble IL-6 receptor down-regulation of human type II collagen gene expression in articular chondrocytes requires a decrease of Sp1.Sp3 ratio and of the binding activity of both factors to the COL2A1 promoter. J Biol Chem 2008; 283(8): 4850–65
  Article PubMed CAS Google Scholar
• Mathy-Hartert M, Hogge L, Sanchez C, et al. Interleukin-1β and interleukin-6 disturb the anti-oxidant enzyme system in bovine chondrocytes: a possible explanation for oxidative stress generation. Osteoarthritis Cartilage 2008; 16(7): 756–63
  Article PubMed CAS Google Scholar
• Roach HI. The complex pathology of osteoarthritis: even mitochondria are involved. Arthritis Rheum 2008; 58(8): 2217–8
  Article PubMed Google Scholar
• Guillén MI, Megías J, Clérigues V, et al. The CO-releasing molecule CORM-2 is a novel regulator of the inflammatory process in osteoarthritic chondrocytes. Rheumatology (Oxford) 2008; 47(9): 1323–8
  Article CAS Google Scholar
• Tanaka M, Miyajima A. Oncostatin M, a multifunctional cytokine. Rev Physiol Biochem Pharmacol 2003; 149: 39–52
  Article PubMed CAS Google Scholar
• Hui W, Rowan AD, Richards CD, et al. Oncostatin M in combination with tumor necrosis factor α induces cartilage damage and matrix metalloproteinases expression in vitro and in vivo. Arthritis Rheum 2003; 48(12): 3404–18
  Article PubMed CAS Google Scholar
• Hui W, Barksby HE, Young DA, et al. Oncostatin M in combination with tumour necrosis factor α induces a chondrocyte membrane associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or -2. Ann Rheum Dis 2005; 64(11): 1624–32
  Article PubMed CAS Google Scholar
• El Mabrouk M, Qureshi HY, Li WQ, et al. Interleukin-4 antagonizes oncostatin M and transforming growth β-induced responses in articular chondrocytes. J Cell Biochem 2008; 103(2): 588–97
  Article PubMed CAS Google Scholar
• Durigova M, Roughley PJ, Mort JS. Mechanism of proteoglycan aggregate degradation in cartilage stimulated by oncostatin M. Osteoarthritis Cartilage 2008; 16(1): 98–104
  Article PubMed CAS Google Scholar
• Durigova M, Soucy P, Fushimi K, et al. Characterization of an ADAMTS-5-mediated cleavage site in aggrecan in OSM-stimulated bovine cartilage. Osteoarthritis Cartilage 2008; 16(10): 1245–52
  Article PubMed CAS Google Scholar
• Barksby HE, Hui W, Wappler I, et al. Interleukin-1 in combination with oncostatin M up-regulates multiple genes in chondrocytes: implications for cartilage destruction and repair. Arthritis Rheum 2006; 54(2): 540–50
  Article PubMed CAS Google Scholar
• El Mabrouk M, Sylvester J, Zafarullah M. Signaling pathways in oncostatin M-induced aggrecanase-1 and matrix metalloproteinase-13 expression in human articular chondrocytes. Biochim Biophys Acta 2007; 1773(3): 309–20
  Article PubMed CAS Google Scholar
• Malemud CJ, Pearlman E. Targeting JAK/STAT signaling pathway in inflammatory diseases. Curr Signal Transduct Ther 2009; 4(3): 201–21
  Article CAS Google Scholar
• Little CB, Flannery CR, Hughes CE, et al. Cytokine induced matrix metalloproteinase expression and activity does not correlate with focal susceptibility of articular cartilage to degeneration. Osteoarthritis Cartilage 2005; 13(2): 162–70
  Article PubMed CAS Google Scholar
• Sanchez C, Deberg MA, Piccardi N, et al. Osteoblasts from the sclerotic subchondral bone downregulate aggrecan but upregulate metalloproteinase expression by chondrocytes. This effect is mimicked by interleukin-6, -1β and oncostatin M pre-treated non-sclerotic osteoblasts. Osteoarthritis Cartilage 2005; 13(11): 979–87
  Article PubMed CAS Google Scholar
• Manicourt DH, Poilvache P, Van Egeren A, et al. Synovial fluid levels of tumor necrosis factor α and oncostatin M correlate with levels of markers of the degradation of crosslinked collagen and cartilage aggrecan in rheumatoid arthritis but not in osteoarthritis. Arthritis Rheum 2000; 43(2): 281–8
  Article PubMed CAS Google Scholar
• Moreau JF, Donaldson DD, Bennett F, et al. Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells. Nature 1988; 336(6200): 690–2
  Article PubMed CAS Google Scholar
• Auernhammer CJ, Melmed S. Leukemia-inhibitory factor-neuroendocrine modulator of endocrine function. Endocr Rev 2000; 21(3): 313–45
  Article PubMed CAS Google Scholar
• Linker R, Gold R, Luhder F. Function of neutrotrophic factors beyond the nervous system: inflammation and autoimmune demyelination. Crit Rev Immunol 2009; 29(1): 43–68
  Article PubMed CAS Google Scholar
• Starr R, Novak U, Willson TA, et al. Distinct roles for leukemia inhibitory factor α-chain and gp 130 in cell type-specific signal transduction. J Biol Chem 1997; 272(32): 19982–86
  Article PubMed CAS Google Scholar
• Malemud CJ. Small molecular weight inhibitors of stress-activated and mitogen-activated protein kinases. Mini Rev Med Chem 2006; 6(6): 689–98
  Article PubMed CAS Google Scholar
• Malemud CJ. Inhibitors of stress-activated and mitogen-activated protein kinase pathways. Curr Opin Pharmacol 2007; 7(3): 339–43
  Article PubMed CAS Google Scholar
• Malemud CJ, Miller AH. Pro-inflammatory cytokine-induced SAP/MAPK and JAK/STAT in rheumatoid arthritis and the new anti-depression drugs. Expert Opin Ther Targets 2008; 12(2): 171–83
  Article PubMed CAS Google Scholar
• Lotz M, Moats T, Villiger PM. Leukemia inhibitory factor is expressed in cartilage and synovium and can contribute to the pathogenesis of arthritis. J Clin Invest 1992; 90(3): 888–96
  Article PubMed CAS Google Scholar
• Alaaeddine N, Di Battista JA, Pelleter J-P, et al. Differential effects of IL-8, LIF (pro-inflammatory) and IL-11 (anti-inflammatory) on TNF-α-induced PGE2 release and on signalling pathways in human OA synovial fibroblasts. Cytokine 1999; 11(12): 1020–30
  Article PubMed CAS Google Scholar
• Lisignoli G, Piacentini A, Toneguzzi S, et al. Osteoblasts and stromal cells isolated from femora in rheumatoid arthritis (RA) and osteoarthritis (OA) patients express IL-11, leukaemia inhibitory factor and oncostatin M. Clin Exp Immunol 2000; 119(2) 346–53
  Article PubMed CAS Google Scholar
• Fan Z, Bau B, Yang H, et al. IL-1β induction of IL-6 and LIF in normal articular human chondrocytes involves the ERK, p38 and NFκB signaling pathways. Cytokine 2004; 28(1): 17–24
  Article PubMed CAS Google Scholar
• Sandell LJ, Xing X, Franz C, et al. Exuberant expression of chemokine genes by adult human articular chondrocytes in response to IL-1β. Osteoarthritis Cartilage 2008; 16(12): 1560–71
  Article PubMed CAS Google Scholar
• Malemud CJ, Reddy SK. Targeting cytokines, chemokines and adhesion molecules in rheumatoid arthritis. Curr Rheum Rev 2008; 4(4): 219–34
  Article CAS Google Scholar
• Fry TJ, Mackall CL. Interleukin-7: from bench to clinic. Blood 2002; 99(11): 3892–904
  Article PubMed CAS Google Scholar
• Surh CD, Sprent J. Homeostasis of naïve and memory T cells. Immunity 2008; 29(6): 848–62
  Article PubMed CAS Google Scholar
• Sakkas LI, Scanzello C, Johanson N, et al. T-cells and T-cell transcripts in the synovial membrane in patients with osteoarthritis. Clin Diagn Lab Immunol 1998; 5(4): 430–7
  PubMed CAS Google Scholar
• Haynes MK, Hume EL, Smith JB. Phenotypic characterization of inflammatory cells from osteoarthritic synovial fluids. Clin Immunol 2002; 105(3): 315–25
  Article PubMed CAS Google Scholar
• Nakamura H, Tanaka M, Masuko-Hongo K, et al. Enhanced production of MMP-1, MMP-3, MMP-13, and Rantes by interaction of chondrocytes with autologous T cells. Rheumatol Int 2006; 26(11): 984–90
  Article PubMed CAS Google Scholar
• Sakkas LI, Platsoucas CD. The role of T cells in the pathogenesis of osteoarthritis. Arthritis Rheum 2007; 56(2): 409–24
  Article PubMed Google Scholar
• Rollin R, Marco F, Jover JA, et al. Early lymphocyte activation in the synovial microenvironment in patients with osteoarthritis: comparison with rheumatoid arthritis patients and healthy controls. Rheumatol Int 2008; 28(8): 757–64
  Article PubMed CAS Google Scholar
• Van Roon JA, Lafeber FP. Role of interleukin-7 in degenerative and inflammatory joint diseases. Arthritis Res Ther 2008; 10(2): 107
  Article PubMed CAS Google Scholar
• Long D, Blake S, Song XY, et al. Human articular chondrocytes produce IL-7 and respond to IL-7 with increased production of matrix metalloproteinase-13. Arthritis Res Ther 2008; 10(1): R23
  Article PubMed CAS Google Scholar
• Yammani RR, Long DD, Loeser RF. Interleukin-7 stimulates secretion of S100A by activating the JAK/STAT signaling pathway in human articular chondrocytes. Arthritis Rheum 2009; 60(3): 792–800
  Article PubMed CAS Google Scholar
• Geginat J, Campagnaro S, Sallusto F, et al. TCR-in-dependent proliferation and differentiation of human CD4+ cell subsets induced by cytokines. Adv Exp Med Biol 2002; 512: 107–12
  Article PubMed CAS Google Scholar
• van Roon JAG, Hartgring SAY, Wenting-van Wijk M, et al. Persistence of interleukin-7 activity and levels on tumor necrosis factor α blockade in patients with rheumatoid arthritis. Ann Rheum Dis 2007; 66(5): 664–9
  Article PubMed CAS Google Scholar
• Dinarello CA. The IL-1 family and inflammatory diseases. Clin Exp Rheumatol 2002; 20(5 Suppl. 27): S1–13
  PubMed CAS Google Scholar
• Nakanishi K, Yoshimoto T, Tsutsui T, et al. Interleukin-18 regulates both TH1 and TH2 responses. Annu Rev Immunol 2001; 19:423–74
  Article PubMed CAS Google Scholar
• Singh R, Ahmed S, Malemud CJ, et al. Epigallocatechin-3-gallate selectively inhibits interleukin-1 b-induced activation of mitogen activated protein kinase subgroup c-Jun-N-terminal kinase in human osteoarthritis chondrocytes. J Orthop Res 2003; 21(1): 102–9
  Article PubMed CAS Google Scholar
• Notoya K, Jovanovic DV, Reboul P, et al. The induction of cell death in human osteoarthritis chondrocytes by nitric oxide is related to the production of prostaglandin E2 via the induction of cyclooxygenase-2. J Immunol 2000; 165(6): 3402–10
  PubMed CAS Google Scholar
• Matsui K, Tsutsui H, Nakanishi K. Pathophysiological roles for IL-18 in inflammatory arthritis. Expert Opin Ther Targets 2003; 7(6): 701–24
  Article PubMed CAS Google Scholar
• Lee JK, Kim SH, Lewis EC, et al. Differences in signaling pathways by IL-1β and IL-18. Proc Natl Acad Sci U S A 2004; 101(23): 8815–20
  Article PubMed CAS Google Scholar
• Wannamaker W, Davies R, Namchuk M, et al. (S)-1-((S)-2-{[1-(4-amino-3-chloro-phenyl)-methanoyl]-amino}-3, 3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX–765), an orally available selective interleukin (IL)-converting enzyme/caspase-1 inhibitor, exhibits potent anti-inflammatory activities by inhibiting the release of IL-1β and IL-18. J Pharmacol Exp Ther 2007; 321(2): 509–16
  Article PubMed CAS Google Scholar
• Gracie JA, Forsey RJ, Chan WL, et al. A proinflammatory role for IL-18 in rheumatoid arthritis. J Clin Invest 1999; 104(10): 1393–401
  Article PubMed CAS Google Scholar
• Wei XQ, Leung BP, Arthur HM, et al. Reduced incidence and severity of collagen-induced arthritis in mice lacking IL-18. J Immunol 2001; 166(1): 517–21
  PubMed CAS Google Scholar
• Ye XJ, Tang B, Ma Z, et al. The role of interleukin-18 in collagen-induced arthritis in the BB rat. Clin Exp Immunol 2004; 136(3): 440–7
  Article PubMed CAS Google Scholar
• Futani H, Okayama A, Matsui K, et al. Relationship between interleukin-18 and PGE2 in synovial fluid of osteoarthritis: a potential therapeutic target of cartilage degradation. J Immunother 2002; 25Suppl. 1: S61–4
  Article PubMed CAS Google Scholar
• Dai SM, Shan ZZ, Nishioka K, et al. Implication of interleukin 18 in production of matrix metalloproteinases in articular chondrocytes in arthritis: direct effect on chondrocytes may not be pivotal. Ann Rheum Dis 2005; 64(5): 735–42
  Article PubMed CAS Google Scholar
• John T, Kohl B, Mobasheri A, et al. Interleukin-18 induces apoptosis in human articular chondrocytes. Histol Histopathol 2007; 22(5): 469–82
  PubMed CAS Google Scholar
• Verri Jr WA, Cunha TM, Parada CA, et al. Antigen-induced inflammatory mechanical hypernocioception in mice is mediated by IL-18. Brain Behav Immun 2007; 21(5): 535–43
  Article PubMed CAS Google Scholar
• Honorati MC, Neri S, Cattini L, et al. Interleukin-17, a regulator of angiogenic factor release by synovial fibroblasts. Osteoarthritis Cartilage 2006; 14(4): 345–52
  Article PubMed CAS Google Scholar
• Van Bezooijen RL, Van Der Wee-Pals L, Papapoulos SE, et al. Interleukin 17 synergizes with tumour necrosis factor alpha to induce cartilage destruction in vitro. Ann Rheum Dis 2002; 61(10): 870–6
  Article PubMed Google Scholar
• Miljkovic D, Trajkovic V. Inducible nitric oxide synthase activation by interleukin-17. Cytokine Growth Factor Rev 2004; 15(1): 21–32
  Article PubMed CAS Google Scholar
• Honorati MC, Bovara M, Cattini L, et al. Contribution of IL-17 to human cartilage degradation and synovial inflammation in osteoarthritis. Osteoarthritis Cartilage 2002; 10(10): 799–807
  Article PubMed CAS Google Scholar
• Honorati MC, Cattini L, Facchini A. VEGF production by osteoarthritic chondrocytes cultured in micromass stimulated by IL-17 and TNF-α. Connect Tissue Res 2007; 48(5): 239–45
  Article PubMed CAS Google Scholar
• Lubberts E, Koenders MI, van den Berg WB. The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models. Arthritis Res Ther 2005; 7(1): 29–37
  Article PubMed CAS Google Scholar
• Aigner T, Van der Kraan P, Van den Berg WB. Osteoarthritis and inflammation: inflammatory changes in osteoarthritic synoviopathy. In: Buckwalter JA, Lotz M, Stoltz J-F, editors. Osteoarthritis, inflammation and degradation: a continuum. Amsterdam: IOS Press, 2007: 219–35
  Google Scholar
• Wang G, Matsuura I, He D, et al. Transforming growth factor-β-inducible phosphorylation of Smad3. J Biol Chem 2009; 284(15): 9663–73
  Article PubMed CAS Google Scholar
• Scharstuhl A, Vitters EL, van der Kraan PM, et al. Reduction of osteophyte formation and synovial thickening by adenoviral overexpression of transforming growth factor β/bone morphogenetic protein inhibitors during experimental osteoarthritis. Arthritis Rheum 2003; 48(12): 3442–51
  Article PubMed CAS Google Scholar
• Roman-Blas JA, Stokes DG, Jimenez SA. Modulation of TGF-β signaling by proinflammatory cytokines in articular chondrocytes. Osteoarthritis Cartilage 2007; 15(12): 1367–77
  Article PubMed CAS Google Scholar
• Blaney Davidson EN, Vitters EL, van den Berg WB, et al. TGF β-induced cartilage repair is maintained but fibrosis is blocked in the presence of Smad7. Arthritis Res Ther 2006; 8(3): R65
  Article PubMed CAS Google Scholar
• Blaney Davidson EN, Scharstuhl A, Vitters EL, et al. Reduced transforming growth factor-beta signaling in cartilage of old mice: role in impaired repair capacity. Arthritis Res Ther 2005; 7(6): R1338–47
  Article PubMed CAS Google Scholar
• Wu Q, Kim KO, Sampson ER, et al. Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice. Arthritis Rheum 2008; 58(10): 3132–44
  Article PubMed CAS Google Scholar
• Nakajima M, Kizawa H, Saitoh M, et al. Mechanisms for asporin function and regulation in articular cartilage. J Biol Chem 2007; 282(44): 32185–92
  Article PubMed CAS Google Scholar
• Kizawa H, Kou I, Iida A, et al. An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis. Nat Genet 2005; 37(2): 138–44
  Article PubMed CAS Google Scholar
• Kou I, Nakajima M, Ikegawa S. Expression and regulation of the osteoarthritis-associated protein asporin. J Biol Chem 2007; 282(44): 32193–9
  Article PubMed CAS Google Scholar
• Lires-Deän M, Caramés B, Cillero-Pastor B, et al. Anti-apoptotic effect of transforming growth factor-β1 on human articular chondrocytes: role of protein phosphatase 2A. Osteoarthritis Cartilage 2008; 16(11): 1370–8
  Article PubMed Google Scholar
• Rollín R, Alvarez-Lafuente R, Marco F, et al. Abnormal transforming growth factor-β expression in mesenchymal stem cells from patients with osteoarthritis. J Rheumatol 2008; 35(5): 904–6
  PubMed Google Scholar
• Nelson AE, Fang F, Shi XA, et al. Failure of transforming growth factor-beta (TGF-β) as a biomarker of radiographic osteoarthritis of the knee and hip: a cross-sectional analysis in the Johnston County Osteoarthritis Project. Osteoarthritis Cartilage 2009; 17(6): 772–6
  Article PubMed CAS Google Scholar
• Schmidt MB, Chen EH, Lynch SE. A review of the effects of insulin-like growth factor and platelet derived growth factor on in vivo cartilage healing and repair. Osteoarthritis Cartilage 2006; 14(5): 403–12
  Article PubMed CAS Google Scholar
• Loeser RF, Shanker G, Carlson CS, et al. Reduction in the chondrocyte response to insulin-like growth factor 1 in aging and osteoarthritis: studies in a non-human primate model of naturally occurring disease. Arthritis Rheum 2000; 43(9): 2110–20
  Article PubMed CAS Google Scholar
• Okada A, Mochizuki S, Yatabe T, et al. ADAM-12 (meltrin-α) is involved in chondrocyte proliferation via cleavage of insulin-like growth factor binding protein 5 in osteoarthritic cartilage. Arthritis Rheum 2008; 58(3): 778–9
  Article PubMed CAS Google Scholar
• Cravero JD, Carlson CS, Im HJ, et al. Increased expression of the Akt/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis. Arthritis Rheum 2009; 60(2): 492–500
  Article PubMed CAS Google Scholar
• Du K, Herzig S, Kulkarni RN, et al. TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science 2003; 300(5625): 1574–7
  Article PubMed CAS Google Scholar
• Massicotte F, Aubry I, Martel-Pelletier J, et al. Abnormal insulin-like growth factor 1 signaling in human osteoarthritic subchondral bone osteoblasts. Arthritis Res Ther 2006; 8(6): R177
  Article PubMed CAS Google Scholar
• Sawaji Y, Hynes J, Vincent T, et al. Fibroblast growth factor 2 inhibits induction of aggrecanase activity in human articular cartilage. Arthritis Rheum 2008; 58(11): 3498–509
  Article PubMed CAS Google Scholar
• Chia SL, Sawaji Y, Burleigh A, et al. Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMT-5 and delays cartilage degradation in murine osteoarthritis. Arthritis Rheum 2009; 60(7): 2019–27
  Article PubMed CAS Google Scholar
• Vincent TL, McLean CJ, Full LE, et al. FGF-2 is bound to perlecan in the pericellular matrix of articular cartilage where it acts as a chondrocyte mechanotransducer. Osteoarthritis Cartilage 2007; 15(7): 752–63
  Article PubMed CAS Google Scholar
• Huang K, Wu LD. Aggrecanase and aggrecan degradation in osteoarthritis: a review. J Int Med Res 2008; 36(6): 1149–60
  PubMed CAS Google Scholar
• Daouti S, Latario B, Nagulapalli S, et al. Development of comprehensive functional genomic screens to identify novel mediators of osteoarthritis. Osteoarthritis Cartilage 2005; 13(6): 508–18
  Article PubMed CAS Google Scholar
• Pohlers D, Huber R, Ukena B, et al. Expression of platelet-derived growth factors C and D in the synovial membrane of patients with rheumatoid arthritis and osteoarthritis. Arthritis Rheum 2006; 54(3): 788–94
  Article PubMed CAS Google Scholar
• Kubota S, Takigawa M. Role of CCN2/CTGF/Hcs24 in bone growth. Int Rev Cytol 2007; 257: 1–41
  Article PubMed CAS Google Scholar
• Tardif G, Reboul P, Pelletier J-P, et al. Ten years in the life of an enzyme: the story of human MMP-13 (collagenase-3). Mod Rheumatol 2004; 14(3): 197–204
  Article PubMed CAS Google Scholar
• Omoto S, Nishida K, Yamaai Y, et al. Expression and localization of connective tissue growth factor (CTGF/Hcs24/CCN2) in osteoarthritic cartilage. Osteoarthritis Cartilage 2004; 12(10): 771–8
  Article PubMed Google Scholar
• Nishida T, Kubota S, Kojima S, et al. Regeneration of defects in articular cartilage in rat knee joints by CCN2 (connective tissue growth factor). J Bone Miner Res 2004; 19(8): 1308–19
  Article PubMed CAS Google Scholar
• Blaney Davidson EN, Vitters EL, Mooren FM, et al. Connective tissue growth factor/CCN2 overexpression in mouse synovial lining results in transient fibrosis and cartilage damage. Arthritis Rheum 2006; 54(5): 1653–61
  Article PubMed CAS Google Scholar
• Woods A, Pala D, Kennedy L, et al. Rac1 signaling regulates CTGF/CCN2 gene expression via TGFβ/Smad signaling in chondrocytes. Osteoarthritis Cartilage 2009; 17(3): 406–13
  Article PubMed CAS Google Scholar
• Genovese MC, McKay JD, Nasonov EL, et al. Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: the Tocilizumab in Combination with Traditional Disease-modifying Antirheumatic Drug Therapy Study. Arthritis Rheum 2008; 58(10): 2968–80
  Article PubMed CAS Google Scholar
• Bliddal H, Terslev L, Qvistgaard E, et al. A randomized, controlled study of a single intra-articular injection of etanercept or glucocorticoids in patients with rheumatoid arthritis. Scand J Rheumatol 2006; 35(5): 341–5
  Article PubMed CAS Google Scholar
• van der Bijl AE, Teng YKO, van Oosterhout M, et al. Efficacy of intraarticular infliximab in patients with chronic or recurrent gonarthritis: a clinical randomized trial. Arthritis Care Res 2009; 61(7): 974–8
  Article CAS Google Scholar
• Kim HA, Cho M-L, Choi HY, et al. The catabolic pathway mediated by Toll-like receptors in human osteoarthritic chondrocytes. Arthritis Rheum 2006; 54(7): 2152–63
  Article PubMed CAS Google Scholar
• Zhang Q, Hui W, Litherland GJ, et al. Differential Toll-like receptor-dependent collagenase expression in chondrocytes. Ann Rheum Dis 2008; 67(11): 1633–41
  Article PubMed CAS Google Scholar
• Scanzello CR, Plaas A, Crow MK. Innate immune system activation in osteoarthritis: is osteoarthritis a chronic wound? Curr Opin Rheumatol 2008; 20(5): 565–72
  Article PubMed CAS Google Scholar
• Yudoh K, Nguyen T, Nakamura H, et al. Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function. Arthritis Res Ther 2005; 7(2): R380–91
  Article PubMed CAS Google Scholar
• Vicini P, Incerti M, Cardile V, et al. Benzo[d]isothiazol-3-yl-benzamidines: a class of protective agents on culture of human cartilage and chondrocytes stimulated by IL-1β. ChemMedChem 2007; 2(1): 113–9
  Article PubMed CAS Google Scholar
• Cillero-Pastor B, Caramés B, Lires-Deàn M, et al. Mitochondrial dysfunction activates cyclooxygenase 2 expression in cultured normal human chondrocytes. Arthritis Rheum 2008; 58(8): 2409–19
  Article PubMed CAS Google Scholar
• Kim HA, Blanco FJ. Cell death and apoptosis in osteoarthritic cartilage. Curr Drug Targets 2007; 8(2): 333–45
  Article PubMed CAS Google Scholar
• Lago R, Gomez R, Otero M, et al. A new player in cartilage homeostasis: adiponectin induces nitric oxide synthase II and pro-inflammatory cytokines in chondrocytes. Osteoarthritis Cartilage 2008; 16(9): 1101–9
  Article PubMed CAS Google Scholar
• Giatromanolaki A, Sivridis E, Athanassou N, et al. The angiogenic pathway ‘vascular endothelial growth factor/flk-1 (KDR) receptor’ in rheumatoid arthritis and osteoarthritis. J Pathol 2001; 194(1): 101–8
  Article PubMed CAS Google Scholar
• Giatromanolaki A, Sivridis E, Maltezos E, et al. Upregulated hypoxia-inducible factor-1α and -2α in rheumatoid arthritis and osteoarthritis. Arthritis Res Ther 2003; 5(4): R193–201
  Article PubMed CAS Google Scholar
• Valdes AM, Lories RJ, van Meurs JB, et al. Variation at the ANP32a gene is associated with risk of hip osteoarthritis in women. Arthritis Rheum 2009; 60(7): 2046–54
  Article PubMed CAS Google Scholar
• Egli RJ, Southam L, Wilkins JM, et al. Functional analysis of the osteoarthritis susceptibility-associated GDF5 regulatory polymorphism. Arthritis Rheum 2009; 60(7): 2055–64
  Article PubMed CAS Google Scholar
• Nixon AJ, Haupt L, Frisbie DD, et al. Gene-mediated restoration of cartilage matrix by combination insulin-like growth factor-I/interleukin receptor antagonist therapy. Gen Ther 2005; 12(2): 177–86
  Article CAS Google Scholar
• Malemud CJ. Gene therapy for arthritis: defining novel gene targets. Gen Ther Mol Biol 2007; 11: 27–36
  Google Scholar