- Dharmarajan TS, Shah AB, Dharmarajan L. Amiodarone-induced pulmonary toxicity: potentially fatal, recognize early during life! J Am Geriatr Soc 2008 Jul; 56(7): 1363–1
- Charlier R, Deltour G, Tondeur R. Recherche dans la serie des benzofurannes, VII: etude pharmacologique preliminaire du butyl-2 (diiodo 3’5’-beta-N-diethylaminoethoxy-4′benzoyl)-3 benzofurannes. Arch Int Pharma-codyn Ther 1962; 139: 255–62
CAS Google Scholar
- Charlier R, Delaunois G, Bauthier J. Recherche dans la serie des benzofurannes, XL: propriete anti-arrhythmiques de l’amiodarone. Cardiologia 1969; 54: 83–9
Article PubMed CAS Google Scholar
- Nademanee K, Singh BN, Stevenson WG, et al. Amiodarone and post-MI patients. Circulation 1993; 88: 764–8
Article PubMed CAS Google Scholar
- Vassallo P, Trohman RG. Prescribing amiodarone: an evidence-based review of clinical indications. JAMA 2007; 298(11): 1312–22
Article PubMed CAS Google Scholar
- Goldschlager N, Epstein AE, Naccarelli GV, et al. A practical guide for clinicians who treat patients with amiodarone: 2007. Heart Rhythm 2007; 4: 1250–9
Article PubMed Google Scholar
- Ernawati DK, Stafford L, Hughes JD. Amiodarone-induced pulmonary toxicity. Br J Clin Pharmacol 2008 July; 66(1): 82–7
Article PubMed CAS Google Scholar
- Rotmensch HH, Liron M, Tupilski M, et al. Possible association of pneumonitis with amiodarone therapy [letter]. Am Heart J 1980; 100: 412–3
Article PubMed CAS Google Scholar
- Ikäheimo K, Kettunen R, Mäntyjärvi M. Visual functions and adverse ocular effects in patients with amiodarone medication. Acta Ophthalmol Scand 2002; 80: 59–63
Article PubMed Google Scholar
- Tsang W, Houlden RL. Amiodarone-induced thyrotoxicosis: a review. Can J Cardiol 2009 Jul; 25(7): 421–4
Article PubMed CAS Google Scholar
- Babatin M, Lee SS, Pollak PT. Amiodarone hepato-toxicity: review. Curr Vasc Pharmacol 2008 Jul; 6(3): 228–36
Article PubMed CAS Google Scholar
- Dezile G, Roullier A, Arbeille-Brassart B. Interstitial pneumopathy in subjects treated with amiodarone [in French]. Presse Med 1983; 12: 2747–50
PubMed CAS Google Scholar
- Yamada Y, Shiga T, Matsuda N, et al. Incidence and predictors of pulmonary toxicity in Japanese patients receiving low-dose amiodarone. Circ J 2007; 71: 1610–6
Article PubMed CAS Google Scholar
- Sunderji R, Kanji Z, Gin K. Pulmonary effects of low dose amiodarone: a review of the risks and recommendations for surveillance. Can J Cardiol 2000; 16: 1435–40
PubMed CAS Google Scholar
- Singh SN, Fisher SG, Singh BN, et al. Pulmonary effect of amiodarone in patients with heart failure. JACC 1997; 30: 514–7
PubMed CAS Google Scholar
- Labombarda F, Ou P, Stos B, et al. Acute amiodarone-induced pulmonary toxicity: an association of risk factors in a child operated by arterial switch operation. Congenit Heart Dis 2008; 3: 365–7
Article PubMed Google Scholar
- Singh SN, Fletcher RD, Fisher SG, et al. Amiodarone in patients with congestive heart failure and asymptomatic ventricular arrhythmia. N Engl J Med 1995; 333: 77–82
Article PubMed CAS Google Scholar
- Dusman RE, Stanton MS, Miles WM, et al. Clinical features of amiodarone-induced pulmonary toxicity. Circulation 1990; 82: 51–9
Article PubMed CAS Google Scholar
- Magro SA, Lawrence EC, Wheeler SH, et al. Amiodarone pulmonary toxicity: prospective evaluation of serial pulmonary function tests. J Am Coll Cardiol 1988; 12: 781–8
Article PubMed CAS Google Scholar
- Weinberg BA, Miles WM, Klein LS, et al. Five-year follow-up of 589 patients treated with amiodarone. Am Heart J 1993; 125: 109–20
Article PubMed CAS Google Scholar
- Gleadhill IC, Wise RA, Schonfeld SA, et al. Serial lung function testing in patients treated with amiodarone: a prospective study. Am J Med 1989; 86: 4–10
Article PubMed CAS Google Scholar
- Ott MC, Khoor A, Leventhal JP, et al. Pulmonary toxicity in patients receiving low-dose amiodarone. Chest 2003; 123: 646–51
Article PubMed Google Scholar
- Ashrafian H, Davey P. Is amiodarone an underrecognized cause of acute respiratory failure in the ICU? Chest 2001; 120: 275–1
Google Scholar
- Polkey MI, Wilson POG, Rees PJ. Amiodarone pneumonitis: no safe dose. Respir Med 1995; 89: 233–5
Article PubMed CAS Google Scholar
- Greenspon AJ, Kidwell GA, Hurley W, et al. Amiodarone-related postoperative adult respiratory distress syndrome. Circulation 1991 Nov; 84 (5 Suppl.): III407–15
PubMed CAS Google Scholar
- Van der Zeijden H, Znadstra DF. Amiodarone and the development of ARDS after lung surgery. Chest 1995; 107: 885–6
Article PubMed Google Scholar
- Van Mieghem W, Coolen L, Malysse I, et al. Amiodarone and the development of ARDS after lung surgery. Chest 1994; 105: 1642–5
Article PubMed Google Scholar
- Donaldson L, Grant IS, Naysmith MR, et al. Acute amiodarone-induced lung toxicity. Intensive Care Med 1998 Jun; 24(6): 626–30
Article PubMed CAS Google Scholar
- Olshansky B, Sami M, Rubin A, et al. Use of amiodarone for atrial fibrillation in patients with preexisting pulmonary disease in the AFFIRM study. NHLBI AFFIRM investigators. Am J Cardiol 2005; 95: 404–5
Article PubMed CAS Google Scholar
- Bargout R, Jankov A, Dincer E, et al. Amiodarone induces apoptosis of human and rat alveolar epithelial cells in vitro. Am J Physiol Lung Cell Mol Physiol 2000; 278: L1039–44
PubMed CAS Google Scholar
- Uhal BD, Wang R, Laukka J, et al. Inhibition of amiodarone-induced lung fibrosis but not alveolitis by angio-tensin system antagonists. Pharmacol Toxicol 2003; 92: 81–7
Article PubMed CAS Google Scholar
- Uhal BD, Zhang H, Abdul-Hafez A, et al. Amiodarone induces angiotensinogen gene expression in lung alveolar epithelial cells through activation protein-1. Basic Clin Pharmacol Toxicol 2007; 100: 59–66
Article PubMed CAS Google Scholar
- Nikaido A, Tada T, Nakamura K, et al. Clinical features of the effects of angiotensin system antagonists on amiodarone-induced pulmonary toxicity. Int J Cardiol 2010; 140: 328–35
Article PubMed Google Scholar
- Kosseifi SG, Halawa A, Bailey B, et al. Reduction of amiodarone pulmonary toxicity in patients treated with angiotensin-converting enzyme inhibitors and angiotensin receptor blocker. Ther Adv Respir Dis 2009; 3: 289–94
Article PubMed Google Scholar
- Adams PC, Holt DW, Storey GC, et al. Amiodarone and its desethyl metabolite: tissue distribution and morphologic changes during long-term therapy. Circulation 1985; 72: 1064–75
Article PubMed CAS Google Scholar
- Lapinsky SE, Mullen JB, Balter MS. Rapid pulmonary phospholipid accumulation induced by intravenous amiodarone. Can J Cardiol 1993; 9: 322–24
PubMed CAS Google Scholar
- Haffajee CI, Love JC, Canada AT, et al. Clinical pharm-acokinetics and efficacy of amiodarone for refractory tachyarrhythmias. Circulation 1983; 67: 1347–55
Article PubMed CAS Google Scholar
- Kaushik S, Hussain A, Clarke P, et al. Acute pulmonary toxicity after low-dose amiodarone therapy. Ann Thorac Surg 2001;72: 1760–1
Article PubMed CAS Google Scholar
- Kharabsheh S, Abendroth CS, Kozak M. Fatal pulmonary toxicity occurring within two weeks of initiation of amiodarone. Am J Cardiol 2002; 89: 896–8
Article PubMed Google Scholar
- Halliwell WH. Cationic amphiphilic drug-induced phos-pholipidosis. Toxicol Pathol 1997; 25(1): 53–60
Article PubMed CAS Google Scholar
- Hostetler KY, Reasor MJ, Walker RE, et al. Role of phospholipase A inhibition in amiodarone pulmonary toxicity in rats. Biochim Biophys Acta 1986; 875: 400–5
Article PubMed CAS Google Scholar
- Anderson N, Borlak J. Drug-induced phospholipidosis. FEBS Lett 2006; 580: 5533–40
Article PubMed CAS Google Scholar
- Chung MJ, Lee KS, Franquet T, et al. Metabolic lung disease: imaging and histopathologic findings. Eur J Radiol 2005; (54): 233–45
- Bedrossian C, Warren C, Ohar J, et al. Amiodarone pulmonary toxicity: cytopathology, ultrastructure, and immunocytochemistry. Ann Dign Pathol 1997; (1): 47–56
- Kennedy JI, Myers JL, Plumb VJ, et al. Amiodarone pulmonary toxicity: clinical, radiologic, and pathologic correlations. Arch Intern Med 1987; 147: 50–5
Article PubMed CAS Google Scholar
- Minchin RF, Ho PC, Boyd MR. Reductive metabolism of nitrofurantoin by rat lung and liver in vitro. Biochem Pharmacol 1986; 35: 575–80
Article PubMed CAS Google Scholar
- Fantone JC, Phan SH. Oxygen metabolite detoxifying enzyme levels in bleomycin-induced fibrotic lungs. Free Radic Biol Med 1988; 4: 399–402
Article PubMed CAS Google Scholar
- Venkatesan N, Punithavathi V, Chandrakasan G. Curcumin protects bleomycin-induced lung injury in rats. Life Sci 1997; 61: L51–8
Article Google Scholar
- Myers JL, Kennedy JI, Plumb VJ. Amiodarone lung: pathologic findings in clinically toxic patients. Hum Pathol 1987 Apr; 18(4): 349–54
Article PubMed CAS Google Scholar
- Baritussio A, Marzini S, Agostini M, et al. Amiodarone inhibits lung degradation of SP-A and perturbs the distribution of lysosomal enzymes. Am J Physiol Lung Cell Mol Physiol 2001; 281: L1189–99
PubMed CAS Google Scholar
- Reasor MJ, Kacew S. An evaluation of possible mechanisms underlying amiodarone-induced pulmonary toxicity. Proc Soc Exp Biol Med 1996 Sep; 212(4): 297–304
PubMed CAS Google Scholar
- Massey TE, Leeder RG, Rafeiro E, et al. Mechanisms in the pathogenesis of amiodarone-induced pulmonary toxicity. Can J Physiol Pharmacol 1995 Dec; 73(12): 1675–85
Article PubMed CAS Google Scholar
- Otsuka M, Takahashi H, Shiratori M, et al. Reduction of bleomycin induced lung fibrosis by candesartan cilexetil, an angiotensin II type 1 receptor antagonist. Thorax 2004; 59: 31–8
Article PubMed CAS Google Scholar
- Lopez AD, Avasarala S, Grewwal S, et al. Differential role of the Fas/Fas ligant apoptotic pathway in inflammation and lung fibrosis associated with reovirus 1/L induced bronchiolitis obliterans organizing pneumonia and acute respiratory distress syndrome. J Immunol 2009; 183: 8244–57
Article PubMed CAS Google Scholar
- Selman M, Pardo A. The epithelial/fibroblastic pathway in the pathogenesis of idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol 2003; 29: S93–7
PubMed CAS Google Scholar
- Kuruma T, Maruyama T, Hiramatsu S, et al. Relationship between amiodarone-induced subclinical lung toxicity and Th1/Th2 balance. Int J Cardiol 2009 May 15; 134(2): 224–30
Article PubMed Google Scholar
- Reinhart PG, Gairola CG. Amiodarone-induced pulmonary toxicity in Fischer rats: release of tumor necrosis factor alpha and transforming growth factor beta by pulmonary alveolar macrophages. J Toxicol Environ Health 1997; 52: 353–65
PubMed CAS Google Scholar
- Argyriou M, Hountis P, Antonopoulos N, et al. Acute fatal post-CABG low dose amiodarone lung toxicity. Asian Cardiovasc Thorac Ann 2007 Dec; 15(6): e66–8
PubMed Google Scholar
- Skroubis G, Galiatsou E, Metafratzi Z, et al. Amiodarone-induced acute lung toxicity in an ICU setting. Acta An-aesthesiol Scand 2005 Apr; 49(4): 569–71
Article CAS Google Scholar
- Charles PE, Doise JM, Quenot JP, et al. Amiodarone-related acute respiratory distress syndrome following sudden withdrawal of steroids. Respiration 2006; 73: 248–9
PubMed Google Scholar
- Wood DL, Osborn MJ, Rooke J, et al. Amiodarone pulmonary toxicity: report of two cases associated with rapidly progressive fatal respiratory distress syndrome after pulmonary angiography. Mayo Clin Proc 1985; 60: 601–3
Article PubMed CAS Google Scholar
- Behnia M. Association of alveolar hemorrhage with amiodarone: role of bronchoscopy. Tanaffos 2008; 7(2): 75–8
Google Scholar
- Pollak PT. Clinical organ toxicity of antiarrhythmic compounds: ocular and pulmonary manifestations. Am J Cardiol 1999; 84: 37–45
Article Google Scholar
- Camus P, Martin WJ, Rosenow EC. Amiodarone pulmonary toxicity. Clin Chest Med 2004; 25(1): 65–75
Article PubMed Google Scholar
- Fraire AE, Guntupalli KK, Greenberg SD, et al. Amiodarone pulmonary toxicity: a multidisciplinary review of current status. South Med J 1993; 86(1): 67–77
Article PubMed CAS Google Scholar
- Thiyagarajan T, Mahajan V, Katragadda S, et al. Amiodarone induced acute interstitial pneumonitis. BMJ Case Reports. Epub 2009 Mar 6
- Goldstein I, Topilsky M, Segev D, et al. Very early onset of acute amiodarone pulmonary toxicity presenting with hemoptysis. Chest 1997 May; 111(5): 1446–7
Article PubMed CAS Google Scholar
- Iskandar SB, Abi-Salem B, Keith RL, et al. Amiodarone-induced alveolar hemorrhage. South Med J 2006; 99: 383–7
Article PubMed Google Scholar
- Papiris SA, Manali ED, Kalomenidis I, et al. Bench-to-bedside review: pulmonary-renal syndromes — an update for the intensivist. Crit Care 2007; 11(3): 213
Article PubMed Google Scholar
- Gutierez R, del Pozo J, Carrión C, et al. Vasculitis associated with amiodarone treatment [letter]. Ann Pharmacother 1994; 28(4): 537
Google Scholar
- Scharf C, Oechslin EN, Salomon F, et al. Clinical picture: amiodarone-induced pulmonary mass and cutaneous vasculitis. Lancet 2001; 358(9298): 2045
Article PubMed CAS Google Scholar
- Dootson G, Byatt C. Amiodarone-induced vasculitis and a review of the cutaneous side-effects of amiodarone. Clin Exp Dermatol 1994; 19: 422–4
Article PubMed CAS Google Scholar
- Stafford L. Hypersensitivity reaction to amiodarone in a patient with a previous reaction to an iodinated radiocontrast agent. Ann Pharmacother 2007 Jul; 41(7): 1310–4
Article PubMed CAS Google Scholar
- Junge B, Popp W, Ruehm S, et al. Fire eater’s risk: lipoid pneumonia following aspiration of a liquid hydrocarbon mixture. Pneumologie 2002; 56(9): 547–9
Article PubMed CAS Google Scholar
- Spickard III A, Hirschmann JV. Exogenous lipoid pneumonia. Arch Intern Med 1994; 154: 686–92
Article PubMed Google Scholar
- Katzenstein A-LA. Katzenstein and Askin’s surgical pathology of nonneoplastic lung disease: major problems in pathology. 4th ed. Philadelphia (PA): WB Saunders, 2006
Google Scholar
- Barta Z, Szabo GG, Bruckner G, et al. Endogenous lipoid pneumonia associated with undifferentiated connective tissue disease (UCTD). Med Sci Monit 2001; 7: 134–6
PubMed CAS Google Scholar
- Nicholson AG, Wells AU, Hooper J, et al. Successful treatment of endogenous lipoid pneumonia due to Niemann-Pick type b disease with whole-lung lavage. Am J Respir Crit Care Med 2002; 165: 128–31
PubMed Google Scholar
- Chiang IC, Lin YT, Liu GC, et al. Exogenous lipoid pneumonia: serial chest plain roentgenography and high-resolution computerized tomography findings. Kaoh-siung J Med Sci 2003; 19(12): 593–8
Article Google Scholar
- Baron SE, Haramati LB, Rivera VT. Radiological and clinical findings in acute and chronic exogenous lipoid pneumonia. J Thorac Imaging 2003; 18(4): 217–24
Article PubMed Google Scholar
- Rossi SE, Erasmus JJ, Volpacchio M, et al. “Crazy-paving” pattern at thin-section CT of the lungs: radiologic-pathologic overview. Radiographics 2003; 23(6): 1509–19
Article PubMed Google Scholar
- Carrilon Y, Tixier E, Revel D, et al. MR diagnosis of lipoid pneumonia. J Comput Assist Tomogr 1988; 12: 876–7
Article Google Scholar
- Papiris SA, Maniati MA, Manoussakis MN, et al. Ortho-deoxia in amiodarone-induced acute reversible pulmonary damage. Chest 1994 Mar; 105(3): 965–6
Article PubMed CAS Google Scholar
- Martin II WJ, Rosenow III EC. Amiodarone pulmonary toxicity: recognition and pathogenesis. Part I. Chest 1988; 93: 1067–75
Article PubMed Google Scholar
- Polverosi R, Zanellato E, Doroldi C. Thoracic radiography and high resolution computerized tomography in the diagnosis of pulmonary disorders caused by amiodarone. Radiol Med 1996; 92: 58–62
PubMed CAS Google Scholar
- Cottin V, Cordier JF. Eosinophilic pneumonias. Allergy 2005; 60: 841–57
Article PubMed CAS Google Scholar
- Milbrandt EB, Byron W, Davis B. Progressive infiltrates and eosinophilia with multiple possible causes. Chest 2000; 118: 230–4
Article PubMed CAS Google Scholar
- Camus P, Fanton A, Bonniaud P, et al. Interstitial lung disease induced by drugs and radiation. Respiration 2004; 71: 301–26
Article PubMed Google Scholar
- Coudert B, Bailly F, Lombard JN, et al. Amiodarone pneumonitis: bronchoalveolar lavage findings in 15 patients and review of the literature. Chest 1992; 102: 105–12
Article Google Scholar
- Epler GR. Bronchiolitis obliterans organizing pneumonia. Arch Intern Med 2001; 161: 158–64
Article PubMed CAS Google Scholar
- Oymak FS, Dermirbas HM, Mavili E, et al. Brochiolitis obliterans organizing pneumonia: clinical and roentgen-ological features in 26 patients. Respiration 2005; 72: 254–62
Article PubMed Google Scholar
- Malhorta A, Muse VV, Mark EJ. Case records of the Massachusetts General Hospital: weekly clinico-pathological exercises. Case 12–2008. An 82-year old man with dyspnea and pulmonary abnormalities. N Engl J Med 2003; 348: 1574–85
Article Google Scholar
- Antón Aranda E, Alkiza Basanñz R, Laplaza Jiménez Y. Bronchiolitis obliterans organizing pneumonia secondary to amiodarone treatment. Neth J Med 1998; 53: 109–12
Article PubMed Google Scholar
- Jessurum GA, Hoogenberg K, Crinjs HJ. Bronchiolitis obliterans organizing pneumonia during low dose amiodarone therapy. Clin Cardiol 1997; 20: 300–2
Article Google Scholar
- Epler GR. Drug-induced bronchiolitis obliterans organizing pneumonia. Clin Chest Med 2004; 25: 89–94
Article PubMed Google Scholar
- Valle JM, Alvarez D, Antúnez J, et al. Bronchiolitis obliterans organizing pneumonia secondary to amiodarone: a rare aetiology. Eur Respir J 1995; 8: 470–1
Article PubMed CAS Google Scholar
- Camus P, Lombard JN, Perrichon M, et al. Bronchiolitis obliterans organizing pneumonia in patients taking ace-butolol or amiodarone. Thorax 1989; 44: 711–5
Article PubMed CAS Google Scholar
- Conte SC, Pagan V, Murer B. Bronchiolitis obliterans organizing pneumonia secondary to amiodarone: clinical, radiological and histological pattern. Monaldi Arch Chest Dis 1997; 52: 24–6
PubMed CAS Google Scholar
- Oren S, Turkot S, Golzman B, et al. Amiodarone induced bronchiolitis obliterans organizing pneumonia. Respir Med 1996; 90: 167–9
Article PubMed CAS Google Scholar
- Rakita L, Sobol SM, Mostow N, et al. Amiodarone pulmonary toxicity. Am Heart J 1983; 106 (4 Pt 2): 906–16
Article PubMed CAS Google Scholar
- American Thoracic Society/European Respiratory Society. International multidisciplinary consensus classification of the idiopathic interstitial pneumonias. Am J Respir Crit Care Med 2002; 165: 277–304
Google Scholar
- Wolkove N, Baltzan M. Amiodarone pulmonary toxicity. Can Respir J 2009; 16(2): 43–8
PubMed CAS Google Scholar
- Lim KK, Radford DJ. Amiodarone pneumonitis diagnosed by gallium-67 scintigraphy. Heart Lung Circ 2002; 11: 59–62
Article PubMed Google Scholar
- Beasly MB, Franks TJ, Galvin JK, et al. Acute fibrinous organizing pneumonia: a histological pattern of lung injury and possible variant of diffuse alveolar damage. Arch Pathol Lab Med 2002; 126: 1064–70
Google Scholar
- Jarand J, Lee A, Leigh R. Amiodaronoma: an unusual form of amiodarone-induced pulmonary toxicity. CMAJ 2007; 176(10): 1411–3
Article PubMed Google Scholar
- Ruangchira-Urai R, Colby TV, Klein J, et al. Nodular amiodarone lung disease. Am J Surg Pathol 2008; 32: 1654–60
Article PubMed Google Scholar
- Arnon R, Raz I, Chajek-Shaul T, et al. Amiodarone pulmonary toxicity presenting as a solitary lung mass. Chest 1988; 93: 425–7
Article PubMed CAS Google Scholar
- Inampudi P, Gross BH, Tankanow LB. Lung masses in a 70 year old man. Chest 2005; 127: 1433–6
Article PubMed Google Scholar
- Schechter CJ, O’Neill G, Schweppe I, et al. Asymptomatic cavitary pneumonitis due to amiodarone pulmonary toxicity. Tex Heart Inst J 1985; 12: 371–5
PubMed CAS Google Scholar
- Rodriguez Garcia JL, Garcia Nieto JC, Ballesta F, et al. Pulmonary mass and multiple lung nodules mimicking a lung neoplasm as amiodarone induced pulmonary toxicity. Eur J Intern Med 2001; 12: 372–6
Article PubMed Google Scholar
- Sheikhzadeh A, Schäfer U, Schnabel A. Drug-induced lupus erythematosus by amiodarone. Arch Intern Med 2002 Apr 8; 162(7): 834–6
Article PubMed Google Scholar
- Gonzalez-Rothi RJ, Hannan SE, Hood CI, et al. Amiodarone pulmonary toxicity presenting as bilateral exudative pleural effusions. Chest 1987; 92: 179–82
Article PubMed CAS Google Scholar
- Carmichael LC, Newman JH. Lymphocytic pleural exu-date in a patient receiving amiodarone. Br J Clin Pract 1996; 50(4): 228–30
PubMed CAS Google Scholar
- Morelock SY, Sahn SA. Drugs and the pleura. Chest 1999; 116: 212–21
Article PubMed CAS Google Scholar
- Stein B, Zaatari GS, Pine JR. Amiodarone pulmonary toxicity: clinical, cytologic and ultrastructural findings. Acta Cytol 1987; 31(3): 357–61
PubMed CAS Google Scholar
- Akoun G, Gauthier-Rahman S, Milleron BJ. Amiodarone-induced hypersensitivity pneumonitis: evidence of an immunological cell-mediated mechanism. Chest 1984; 85: 133–5
Article PubMed CAS Google Scholar
- Vernhet H, Bousquet C, Durand G, et al. Reversible amiodarone-induced lung disease: HRCT findings. Eur Radiol 2001; 11(9): 1697–703
Article PubMed CAS Google Scholar
- Clarke B, Ward DE, Honey M. Pneumonitis with pleural and pericardial effusion and neuropathy during amiodarone therapy. Int J Cardiol 1985; 8: 81–8
Article PubMed CAS Google Scholar
- Susano R, Caminal L, Ramos D, et al. Amiodarone induced lupus. Letter Ann Rheum Dis 1999; 58: 655–6
Article CAS Google Scholar
- Zimetbaum P. Amiodarone for atrial fibrillation. N Engl J Med 2007; 356: 935–41
Article PubMed CAS Google Scholar
- Endoh Y, Hanai R, Uto K, et al. Diagnostic accuracy of KL-6 as a marker of amiodarone-induced pulmonary toxicity. Pace 2000; 23: 2010–3
PubMed CAS Google Scholar
- Bandoh S, Fujita J, Ohtsuki Y, et al. Sequential changes of KL-6 in sera of patients with interstitial pneumonia associated with polymyositis/dermatomyositis. Ann Rheum Dis 2000; 59(4): 257–62
Article PubMed CAS Google Scholar
- Kobayashi J, Kitamura S. Serum KL-6 for the evaluation of active pneumonitis in pulmonary sarcoidosis. Chest 1996; 109: 1276–82
Article PubMed CAS Google Scholar
- Standertskjöld-Nordenstam CG, Wandtke JC, Hood WB, et al. Amiodarone pulmonary toxicity: chest radiography and CT in asymptomatic patients. Chest 1985; 88: 143–5
Article PubMed Google Scholar
- Rossi SE, Erasmus JJ, McAdams HP, et al. Pulmonary drug toxicity: radiologic and pathologic manifestations. Radiographics 2000; 20: 1245–59
PubMed CAS Google Scholar
- Siniakowicz RM, Narula D, Suster B, et al. Diagnosis of amiodarone pulmonary toxicity with high-resolution computerized tomographic scan. J Cardiovasc Electro-physiol 2001; 12: 431–6
Article CAS Google Scholar
- Kuhlman JE, Teigen C, Ren H, et al. Amiodarone pulmonary toxicity: CT findings in symptomatic patients. Radiology 1990; 177: 121–5
PubMed CAS Google Scholar
- Mason JW. Amiodarone pulmonary toxicity and Professor Hounsfield. J Cardiovasc Electrophysiol 2001; 12: 437–8
Article PubMed CAS Google Scholar
- Nicholson AA, Hayward C. The value of computed tomography in the diagnosis of amiodarone-induced pulmonary toxicity. Clin Radiol 1989; 40: 564–7
Article PubMed CAS Google Scholar
- Marchiori E, Franquet T, Gasparetto TD, et al. Consolidation with diffuse or focal high attenuation: computed tomography findings. J Thorac Imaging 2008; 23: 298–304
Article PubMed Google Scholar
- Hoteit MA, Sanchez W. A bright liver. Clin Gastroenterol Hepatol 2008; 6: xxii
Article PubMed Google Scholar
- Nicholson AA, Caplin JL, Steventon DM. Measurement of tissue-bond amiodarone and its metabolites by computed tomography. Clin Radiol 1994; 49: 14–8
Article PubMed CAS Google Scholar
- Markos J, Veronese ME, Nicholson MR, et al. Value of hepatic computerized tomographing scanning during amiodarone therapy. Am J Cardiol 1985; 56: 89–92
Article PubMed CAS Google Scholar
- Van-Rooij WJ, Vandermeer SC, Van Royen EA, et al. Pulmonary gallium-67 uptake in amiodarone pneumonitis. J Nucl Med 1984; 25: 211–3
PubMed CAS Google Scholar
- Moinuddin M, Rockett J. Gallium scintigraphy in the detection of amiodarone lung toxicity. AJR Am J Roent-genol 1986; 147(3): 607–9
CAS Google Scholar
- Zhu YY, Botvinick E, Dae M, et al. Gallium lung scintigraphy in amiodarone pulmonary toxicity. Chest 1988; 93: 1126–31
Article PubMed CAS Google Scholar
- Foresti V, Carini L, Lovagnini-Scher CA, et al. Amiodarone lung toxicity: role of pulmonary function tests. Int J Clin Pharmacol Res 1987; 7(5): 373–80
PubMed CAS Google Scholar
- Costabel U, Guzman J, Bonella F, et al. Bronchoalveolar lavage in other interstitial lung diseases. Semin Respir Crit Care Med 2007; 28: 514–24
Article PubMed Google Scholar
- Israël-Biet D, Venet A, Caubarrère I, et al. Bronchoalveolar lavage in amiodarone pneumonitis: cellular abnormalities and their relevance to pathogenesis. Chest 1987; 91: 214–21
Article PubMed Google Scholar
- Karpel JP, Ligenza C, Aldrich T, et al. Amiodarone-induced interstitial lung disease: evidence for sensitized T lymphocytes [abstract]. Am Rev Respir Dis 1988; 137: S347
Google Scholar
- Akoun G, Milleron BJ, Badaro DM, et al. Pleural T-lymphocyte subsets in amiodarone-associated pleuro-pneumonitis. Chest 1989; 95: 506–7
Article Google Scholar
- Wilson BP, Jaworski AJ, Donner ME, et al. Amiodarone induced pulmonary toxicity in the rat. Lung 1989; 167: 301–11
Article PubMed CAS Google Scholar
- Nagata N, Suematsu R, Yoshii C, et al. Characterization of amiodarone pneumonitis as related to inflammatory cells and surfactant apoprotein. Chest 1997; 112: 1068–74
Article PubMed CAS Google Scholar
- Mermolja M, Rott T, Debeljak A. Cytology of bronch-oalveolar lavage in some rare pulmonary disorders: pulmonary alveolar proteinosis and amiodarone pulmonary toxicity. Cytopathology 1994; 5: 9–16
Article PubMed CAS Google Scholar
- Xaubet A, Roca J, Rodriguez-Roisin R, et al. Bronch-oalveolar lavage cellular analysis and gallium lung scan in the assessment of patients with amiodarone-induced pneumonitis. Respiration 1987; 52: 272–80
Article PubMed CAS Google Scholar
- Pozzi E, Sada E, Luisetti M, et al. Interstitial pneumopathy and low-dose amiodarone. Eur J Respir Dis 1984; 65: 620–2
PubMed CAS Google Scholar
- Nalos PC, Kass RM, Gang ES, et al. Life-threatening postoperative pulmonary complications in patients with previous amiodarone pulmonary toxicity undergoing cardiothoracic operations. J Thorac Cardiovasc Surg 1987; 93: 904–12
PubMed CAS Google Scholar
- Darey P. Is amiodarone an underrecognized cause of acute respiratory failure in the ICU? Chest 2001; 120: 275–82
Article Google Scholar
- Rosenbaum MB, Chiale PA, Halpern MS, et al. Clinical efficacy of amiodarone as an antiarrhythmic agent. Am J Cardiol 1976; 38: 934–44
Article PubMed CAS Google Scholar
- Homoud MK. Review: amiodarone reduces risk for sudden death but not all-cause mortality in cardiomyopathy. ACP Journal Club. Ann Intern Med 2009; 151: JC4–13
PubMed Google Scholar
- Esinger W, Schleiffer T, Leinberger H, et al. Steroid-refractory amiodarone-induced pulmonary fibrosis: clinical features and morphology after an amiodarone-free interval of 3 months. Dtsch Med Wochenschr 1988; 113: 1638–41
Article PubMed CAS Google Scholar
- Parra O, Ruiz J, Ojanguren I, et al. Amiodarone toxicity: recurrence of interstitial pneumonitis after withdrawal of the drug. Eur Respir J 1989; 2: 905–7
PubMed CAS Google Scholar
- Chendrasekhar A, Barke RA, Druck P. Recurrent amiodarone pulmonary toxicity. South Med J 1996; 89: 85–6
Article PubMed CAS Google Scholar
- Zaher C, Hamer A, Peter T, et al. Low-dose steroid therapy for prophylaxis of amiodarone-induced pulmonary infiltrates [letter]. N Engl J Med 1983; 308: 779
Article PubMed CAS Google Scholar
- Cox G, Johnson J, Kinnear WJ, et al. Amiodarone and the lung: wide variations in clinical practice. Respir Med 2000; 94: 1130–1
Article PubMed CAS Google Scholar
- Card JW, Racz WJ, Brien JF. Attenuation of amiodarone-induced pulmonary fibrosis by vitamin E is associated with suppression of transforming growth factor-beta1 gene expression but not prevention of mitochondrial dysfunction. J Pharmacol Exp Ther 2003; 304(1): 277–83
Article PubMed CAS Google Scholar
- Card JW, Leeder RG, Racz WJ, et al. Effects of dietary vitamin E supplementation on pulmonary morphology and collagen deposition in amiodarone- and vehicle-treated hamsters. Toxicology 1999; 133: 75–84
Article PubMed CAS Google Scholar
- Darmanata JI, Van Zandwijk N, Düren DR, et al. Amiodarone pneumonitis: three further cases with a review of published reports. Thorax 1984; 39: 57–64
Article PubMed CAS Google Scholar
- Riley SA, William SE, Cooke NJ. Alveolitis after treatment with amiodarone. BMJ 1982; 284: 161–2
Article PubMed CAS Google Scholar
- Nicolet-Chatelain G, Prevost MC, Escamilla R, et al. Amiodarone induced pulmonary toxicity: immuno-allergologic tests and bronchoalveolar lavage phospho-lipid content. Chest 1991; 99: 363–9
Article PubMed CAS Google Scholar
- Hughes M, Binning A. Intravenous amiodarone in intensive care: time for reappraisal? Intensive Care Med 2000; 26: 1730–
Google Scholar
- Ohar JA, Jackson Jr F, Redd RM, et al. Usefulness of serial pulmonary function testing as an indicator of amiodarone toxicity. Am J Cardiol 1989; 64: 1322–6
Article PubMed CAS Google Scholar
- Marchlinski FE, Gansler TS, Waxman HL, et al. Amiodarone pulmonary toxicity. Ann Intern Med 1982; 97(6): 839–45
PubMed CAS Google Scholar
- Kudenchuk PJ, Pierson DJ, Greene HL, et al. Prospective evaluation of amiodarone pulmonary toxicity. Chest 1984; 86: 541–8
Article PubMed CAS Google Scholar
- Poll LW, May P, Koch JA, et al. HRCT findings of amiodarone pulmonary toxicity: clinical and radiologic regression. J Cardiovasc Pharmacol Ther 2001; 6: 307–11
Article PubMed CAS Google Scholar