Ghrelin and Obesity: Identifying Gaps and Dispelling Myths. A Reappraisal (original) (raw)
Review ArticleReviewsR
, ANDREAS ALEXANDROU, EFSTATHIOS G. PAPATSOUTSOS, GEORGE MALIETZIS, DIAMANTIS I. TSILIMIGRAS, ALFREDO D. GUERRON and DEMETRIOS MORIS
In Vivo November 2017, 31 (6) 1047-1050;
Abstract
The etiology of obesity is complex. Environmental and genetic causes have been implicated in the development of this disease. Ghrelin is a hormone known to stimulate appetite. There are numerous possible actions through which ghrelin exerts its effect in the body: a) Overproduction of ghrelin, b) reduced ghrelin following meals, and c) increased receptor sensitivity to ghrelin action. Sleeve gastrectomy, a bariatric procedure, leads to reduction of ghrelin levels and subsequently to weight loss. However, there are many limitations to measurement of the fasting plasma level of the active form of ghrelin. The establishment of the exact correlation between ghrelin, appetite and obesity could be vital for the fight against obesity.
- Ghrelin
- obesity
- appetite
- hormone levels
- diet
- bariatric surgery
- review
- Received September 4, 2017.
- Revision received October 2, 2017.
- Accepted October 3, 2017.
- Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved