Drug-Induced Glomerular Disease: Immune-Mediated Injury : Clinical Journal of the American Society of Nephrology (original) (raw)
Moving Points in Nephrology
Drug-Induced Glomerular Disease
Immune-Mediated Injury
*Department of Medicine, Division of Nephrology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania; and
†Department of Pathology and
‡Division of Nephrology, Department of Medicine, Columbia University Medical Center, New York, New York
Correspondence: Dr. Jonathan J. Hogan, Hospital of the University of Pennsylvania, Division of Nephrology, 3400 Spruce Street, 1 Founders, Philadelphia, PA 19104. Email: [email protected]
Abstract
Drug-induced autoimmune disease was initially described decades ago, with reports of vasculitis and a lupus-like syndrome in patients taking hydralazine, procainamide, and sulfadiazine. Over the years, multiple other agents have been linked to immune-mediated glomerular disease, often with associated autoantibody formation. Certain clinical and laboratory features may distinguish these entities from their idiopathic counterparts, and making this distinction is important in the diagnosis and management of these patients. Here, drug-induced, ANCA-associated vasculitis, drug-induced lupus, and drug-associated membranous nephropathy are reviewed.
Copyright © 2015 The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.
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