Pain reduction by electrical brain stimulation in man (original) (raw)
This site uses cookies, tags, and tracking settings to store information that help give you the very best browsing experience. Dismiss this warning
Part 1: Acute administration in periaqueductal and periventricular sites
Donald E. Richardson
Donald E. Richardson Division of Neurological Surgery, Louisiana State University, School of Medicine, New Orleans, Louisiana, and Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California
Search for other papers by Donald E. Richardson in
Current site
Google Scholar
PubMed
Close
M.D.
and
Huda Akil
Huda Akil Division of Neurological Surgery, Louisiana State University, School of Medicine, New Orleans, Louisiana, and Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California
Search for other papers by Huda Akil in
Current site
Google Scholar
PubMed
Close
Ph.D.
View More View Less
Restricted access
Purchase Now
JNS + Pediatrics - 1 year subscription bundle (Individuals Only)
JNS + Pediatrics + Spine - 1 year subscription bundle (Individuals Only)
Purchase Now
JNS + Pediatrics - 1 year subscription bundle (Individuals Only)
JNS + Pediatrics + Spine - 1 year subscription bundle (Individuals Only)
Print or Print + Online Sign in
✓ Acute studies performed in five patients indicate that electrical stimulation of the brain could be a powerful tool for the reduction or control of intractable pain. While chronic or spontaneous pain could be relieved by stimulation of the periaqueductal gray matter, the accompanying side effects render it impossible to stimulate this site regularly. On the other hand, stimulation of medial thalamic sites, particularly medial to the nucleus parafascicularis, yielded good relief of chronic pain at parameters which did not cause many undesirable side effects. The same parameters also produced inhibition of acute pain in two of the five patients.