Correspondence on Letter regarding “Auranofin attenuates hepatic steatosis and fibrosis in nonalcoholic fatty liver disease via NRF2 and NF-κB signaling pathways” (original) (raw)

Articles

Letter to the Editor

Clinical and Molecular Hepatology 2023;29(1):171-172.
Published online: November 10, 2022

1Department of Translational Medicine, Graduate School of Biomedical Science & Engineering, Hanyang University, Seoul, Korea

2Department of Internal Medicine, Hanyang University Hospital, Hanyang University College of Medicine, Seoul, Korea

Corresponding author : Dae Won Jun Department of Internal Medicine, Hanyang University College of Medicine, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Korea Tel: +82-2-2290-8338, Fax: +82-2-972-0068, E-mail: noshin@hanyang.ac.kr

• Received: November 6, 2022 • Accepted: November 7, 2022

Copyright © 2023 by The Korean Association for the Study of the Liver

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Full Article

Dear Editor,

We appreciate your interest in our study. As pointed out by Liu and Chen [1], non-alcoholic fatty liver disease (NAFLD) has a broad heterogeneous spectrum and a diverse pathophysiology [2-8]. The relationship between auranofin-induced ferroptosis and NAFLD is somewhat complex [9]. It depends on the cell type and disease condition. Ferroptosis is associated with the pathogenesis of NAFLD, and inhibiting ferroptosis can inhibit necrotic cell death, inflammatory cell infiltration, and inflammatory cytokine expression in early-stage NAFLD [9]. However, in late-stage NAFLD and hepatocellular carcinoma, inhibition of ferroptosis is associated with disease progression [10,11]. In previous studies, the expression of glutathione peroxidase (GPX) 4, which protects cells against membrane lipid peroxidation, has been shown to vary according to the severity of NAFLD. In addition, the association between ferroptosis and NAFLD has been observed to vary depending on the animal model of NAFLD. This indicates that ferroptosis may play various roles at different stages of NAFLD. System Xc– and NAFLD also share a complex relationship. A large body of evidence suggests that auranofin induces ferroptosis via the cystineglutamate antiporter system Xc–. Auranofin has been shown to induce ferroptosis via the GSH/GPX axis. Additionally, our previous study indicated that auranofin inhibited system Xc– in macrophages and the NOD-like receptor family pyrin domain containing 3 inflammasome in inflammatory cells [12]. However, ferroptosis can simultaneously induce iron-dependent lipid peroxidation. Yang et al. [13] demonstrated that auranofin at high doses (25 mg/kg) induces ferroptosis but causes lipid peroxidation by inhibiting thioredoxin reductase activity. In conclusion, it is evident that auranofin acts as an inhibitor of system Xc–. However, ferroptosis induced by system Xc– inhibitors appears to play a different role in disease progression depending on the liver cell type and severity of NAFLD. Therefore, for the clinical application of auranofin, it is important to select a target population that is anticipated to have a positive therapeutic effect.

FOOTNOTES

Authors’ contribution

All authors contributed in conception of the work and drafting of the article. All authors provided final approval of the version to be published.

Conflicts of Interest

The authors have no conflicts to disclose.

Abbreviations

NAFLD

non-alcoholic fatty liver disease

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Correspondence on Letter regarding “Auranofin attenuates hepatic steatosis and fibrosis in nonalcoholic fatty liver disease via NRF2 and NF-κB signaling pathways”

Clin Mol Hepatol. 2023;29(1):171-172. Published online November 10, 2022

Correspondence on Letter regarding “Auranofin attenuates hepatic steatosis and fibrosis in nonalcoholic fatty liver disease via NRF2 and NF-κB signaling pathways”

Correspondence on Letter regarding “Auranofin attenuates hepatic steatosis and fibrosis in nonalcoholic fatty liver disease via NRF2 and NF-κB signaling pathways”