Viruses, Autophagy Genes, and Crohn’s Disease (original) (raw)

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Open AccessReview

by

Vanessa M. Hubbard

and

Ken Cadwell

*

Skirball Institute of Biomolecular Medicine, Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA

*

Author to whom correspondence should be addressed.

Submission received: 8 June 2011 /Revised: 12 July 2011 /Accepted: 13 July 2011 /Published: 21 July 2011

Abstract

The etiology of the intestinal disease Crohn’s disease involves genetic factors as well as ill-defined environmental agents. Several genetic variants linked to this disease are associated with autophagy, a process that is critical for proper responses to viral infections. While a role for viruses in this disease remains speculative, accumulating evidence indicate that this possibility requires serious consideration. In this review, we will examine the three-way relationship between viruses, autophagy genes, and Crohn’s disease and discuss how host-pathogen interactions can mediate complex inflammatory disorders.

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MDPI and ACS Style

Hubbard, V.M.; Cadwell, K. Viruses, Autophagy Genes, and Crohn’s Disease. Viruses 2011, 3, 1281-1311. https://doi.org/10.3390/v3071281

AMA Style

Hubbard VM, Cadwell K. Viruses, Autophagy Genes, and Crohn’s Disease. Viruses. 2011; 3(7):1281-1311. https://doi.org/10.3390/v3071281

Chicago/Turabian Style

Hubbard, Vanessa M., and Ken Cadwell. 2011. "Viruses, Autophagy Genes, and Crohn’s Disease" Viruses 3, no. 7: 1281-1311. https://doi.org/10.3390/v3071281

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