Detection of Functional Matrix Metalloproteinases by Zymography (original) (raw)

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JournalBiologyDetection of functional matrix metalloproteinases by zymography

83.3K Views

09:30 min

November 8th, 2010

DOI :

10.3791/2445-v

November 8th, 2010

83,265 Views


Xueyou Hu1, Christine Beeton1

1Department of Molecular Physiology and Biophysics, Baylor College of Medicine

0:00

Title

0:54

Introduction

1:23

Zymography Gel Electrophoresis

3:43

Renaturing and Developing the Gel

6:07

Data Analysis

8:03

Representative Results for the Detection of MMP-2 using Zymography

9:00

Conclusion

This protocol describes an activity-based assay for detecting matrix metalloproteinases in culture supernatants or body fluids.

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Functional Matrix Metalloproteinases

Zymography

MMPs

Zinc containing Endopeptidases

Peptide Bonds

Collagenases

Gelatinases

MT MMP

Stromelysins

Matrilysins

Cell Invasion

Cartilage Degradation

Tissue Remodeling

Wound Healing

Embryogenesis

Rheumatoid Arthritis

Cancer

Chronic Obstructive Pulmonary Disease

MMP 2

Gelatinase A

Type IV Collagenase

Cell Culture Supernatants

Semi quantitative Technique

Polyacrylamide Gel

Sodium Dodecyl Sulfate SDS

Gelatin Substrate

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