Ameliorative Effects of a Polyphenolic Fraction of Cinnamomum zeylanicum L. Bark in Animal Models of Inflammation and Arthritis (original) (raw)

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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).

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by

Badal RATHI

1,

Subhash BODHANKAR

1,*,

V. MOHAN

2 and

Prasad THAKURDESAI

2

1

Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, Pune- 411 038, India

2

Indus Biotech Private Limited, 1, Rahul Residency, Plot Nos. 6 & 7, Off Salunke Vihar Road, Kondhwa, Pune-411 048, Maharashtra, India

*

Author to whom correspondence should be addressed.

Submission received: 19 January 2013 /Accepted: 25 February 2013 /Published: 25 February 2013

Abstract

Cinnamon bark (Cinnamomum zeylanicum Syn C. verum, family: Lauraceae) is one of the oldest traditional medicines for inflammatory- and pain-related disorders. The objective of the present study was to evaluate the efficacy of the polyphenol fraction from Cinnamomum zeylanicum bark (CPP) in animal models of inflammation and rheumatoid arthritis. Dose-response studies of CPP (50, 100, and 200 mg/kg) used in a separate set of in vivo experiments were conducted in acute (carrageenan-induced rat paw edema), subacute (cotton pellet-induced granuloma), and sub-chronic (AIA, adjuvant-induced established polyarthrtis) models of inflammation in rats and the acetic acid-induced writhing model of pain in mice. Effects of CPP on cytokine (IL-2, IL-4, and IFNγ) release from Concanavalin (ConA)-stimulated lymphocytes were also evaluated in vitro. CPP showed a strong and dose-dependent reduction in paw volume, weight loss reversal effects against carrageenan-induced paw edema, and cotton pellet-induced granuloma models in rats. CPP (200 mg/kg p.o. for 10 days) showed a significant reduction in elevated serum TNF-α concentration without causing gastric ulcerogenicity in the AIA model in rats. CPP also demonstrated mild analgesic effects during acute treatment as evidenced by the reduction in the writhing and paw withdrawal threshold of the inflamed rat paw during the acetic acid-induced writhing model and Randall-Selitto test. CPP was found to inhibit cytokine (IL-2, IL-4, and IFNγ) release from ConA-stimulated lymphocytes in vitro. In conclusion, CPP demonstrated prominent action in animal models of inflammation and arthritis and therefore can be considered as a potential anti-rheumatic agent with disease-modifying action.

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MDPI and ACS Style

RATHI, B.; BODHANKAR, S.; MOHAN, V.; THAKURDESAI, P. Ameliorative Effects of a Polyphenolic Fraction of Cinnamomum zeylanicum L. Bark in Animal Models of Inflammation and Arthritis. Sci. Pharm. 2013, 81, 567-590. https://doi.org/10.3797/scipharm.1301-16

AMA Style

RATHI B, BODHANKAR S, MOHAN V, THAKURDESAI P. Ameliorative Effects of a Polyphenolic Fraction of Cinnamomum zeylanicum L. Bark in Animal Models of Inflammation and Arthritis. Scientia Pharmaceutica. 2013; 81(2):567-590. https://doi.org/10.3797/scipharm.1301-16

Chicago/Turabian Style

RATHI, Badal, Subhash BODHANKAR, V. MOHAN, and Prasad THAKURDESAI. 2013. "Ameliorative Effects of a Polyphenolic Fraction of Cinnamomum zeylanicum L. Bark in Animal Models of Inflammation and Arthritis" Scientia Pharmaceutica 81, no. 2: 567-590. https://doi.org/10.3797/scipharm.1301-16

APA Style

RATHI, B., BODHANKAR, S., MOHAN, V., & THAKURDESAI, P. (2013). Ameliorative Effects of a Polyphenolic Fraction of Cinnamomum zeylanicum L. Bark in Animal Models of Inflammation and Arthritis. Scientia Pharmaceutica, 81(2), 567-590. https://doi.org/10.3797/scipharm.1301-16

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