Monoacetylcurcumin strongly regulates inflammatory responses through inhibition of NF-κB activation (original) (raw)

• Authors:
  • Masayuki Nishida
  • Shin Nishiumi
  • Yoshiyuki Mizushina
  • Yoshimi Fujishima
  • Koji Yamamoto
  • Atsuhiro Masuda
  • Shigeto Mizuno
  • Tsuyoshi Fujita
  • Yoshinori Morita
  • Hiromu Kutsumi
  • Hiromi Yoshida
  • Takeshi Azuma
  • Masaru Yoshida
• View Affiliations
  Affiliations: Division of Gastroenterology, Department of Internal Medicine, Graduate School of Medicine, Kobe University, Hyogo 650-0017, Japan
• Published online on: May 1, 2010 https://doi.org/10.3892/ijmm\_00000402
• Pages: 761-767

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Abstract

Curcumin, a component of turmeric (Curcuma longa), is known to exert a variety of biological functions including anti-inflammatory activity. We examined the inhibitory effects of chemically synthesized derivatives of curcumin against inflammatory responses and compared them with those of curcumin, in order to find derivatives with stronger effects than curcumin. In a cell culture system using the mouse macrophage cell line RAW264.7, monoacetylcurcumin strongly inhibited IκB phosphorylation, nuclear factor (NF)-κB activation and tumor necrosis factor (TNF)-α production induced by lipopolysaccharide (LPS). In addition, oral administration of monoacetylcurcumin to mice led to greater suppression of TNF-α production after LPS stimulation than the administration of curcumin or tetrahydrocurcumin in vivo. Monoacetylcurcumin also inhibited the LPS-induced NF-κB activation in the liver. Collectively, monoacetylcurcumin is a potential chemopreventive agent for treating inflammatory responses more effectively than curcumin.

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• Impact Factor: 5.7
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• CiteScore: 12.3
• CiteScore Rank: Q1: #28/347 Biochemistry, Genetics and Molecular Biology
• Source Normalized Impact per Paper (SNIP): 1.022
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Spandidos Publications style

Nishida M, Nishiumi S, Mizushina Y, Fujishima Y, Yamamoto K, Masuda A, Mizuno S, Fujita T, Morita Y, Kutsumi H, Kutsumi H, et al: Monoacetylcurcumin strongly regulates inflammatory responses through inhibition of NF-κB activation. Int J Mol Med 25: 761-767, 2010.

APA

Nishida, M., Nishiumi, S., Mizushina, Y., Fujishima, Y., Yamamoto, K., Masuda, A. ... Yoshida, M. (2010). Monoacetylcurcumin strongly regulates inflammatory responses through inhibition of NF-κB activation. International Journal of Molecular Medicine, 25, 761-767. https://doi.org/10.3892/ijmm\_00000402

MLA

Nishida, M., Nishiumi, S., Mizushina, Y., Fujishima, Y., Yamamoto, K., Masuda, A., Mizuno, S., Fujita, T., Morita, Y., Kutsumi, H., Yoshida, H., Azuma, T., Yoshida, M."Monoacetylcurcumin strongly regulates inflammatory responses through inhibition of NF-κB activation". International Journal of Molecular Medicine 25.5 (2010): 761-767.

Chicago

Nishida, M., Nishiumi, S., Mizushina, Y., Fujishima, Y., Yamamoto, K., Masuda, A., Mizuno, S., Fujita, T., Morita, Y., Kutsumi, H., Yoshida, H., Azuma, T., Yoshida, M."Monoacetylcurcumin strongly regulates inflammatory responses through inhibition of NF-κB activation". International Journal of Molecular Medicine 25, no. 5 (2010): 761-767. https://doi.org/10.3892/ijmm\_00000402