Loss of merlin-p85 protein complex in NF2-related tumors. (original) (raw)

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• Authors:

  • H Takeshima
  • T Nishi
  • K Yamamoto
  • T Kino
  • H Nakamura
  • H Saya
  • M Kochi
  • J I Kuratsu
  • Y Ushio

• View Affiliations
  Affiliations: Department of Neurosurgery, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto, 860, Japan.

• Published online on: May 1, 1998 https://doi.org/10.3892/ijo.12.5.1073

• Pages: 1073-1081

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Abstract

The NF2 tumor suppressor gene product, designated merlin, belongs to the family of molecules that links membranous protein with the cytoskeleton. We have previously shown that merlin was co-immunoprecipitated with a cellular protein, p85, in cultured cell. To analyze the alteration of merlin and associated proteins in surgical specimens, we developed a new method for biotin-labeling of whole cellular proteins. Screening of tumor tissues using our method showed that none of malignant gliomas and half of the NF2-related tumors had altered p85 and merlin. Our detection method seems useful for the screening of merlin alterations in NF2-related tumors.

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• Impact Factor: 4.5
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• CiteScore: 9.6
• CiteScore Rank: Q1: #66/404 Oncology
• Source Normalized Impact per Paper (SNIP): 0.88
• SCImago Journal Rank (SJR): 1.099

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Spandidos Publications style

Takeshima H, Nishi T, Yamamoto K, Kino T, Nakamura H, Saya H, Kochi M, Kuratsu J and Ushio Y: Loss of merlin-p85 protein complex in NF2-related tumors.. Int J Oncol 12: 1073-1081, 1998.

APA

Takeshima, H., Nishi, T., Yamamoto, K., Kino, T., Nakamura, H., Saya, H. ... Ushio, Y. (1998). Loss of merlin-p85 protein complex in NF2-related tumors.. International Journal of Oncology, 12, 1073-1081. https://doi.org/10.3892/ijo.12.5.1073

MLA

Takeshima, H., Nishi, T., Yamamoto, K., Kino, T., Nakamura, H., Saya, H., Kochi, M., Kuratsu, J., Ushio, Y."Loss of merlin-p85 protein complex in NF2-related tumors.". International Journal of Oncology 12.5 (1998): 1073-1081.

Chicago

Takeshima, H., Nishi, T., Yamamoto, K., Kino, T., Nakamura, H., Saya, H., Kochi, M., Kuratsu, J., Ushio, Y."Loss of merlin-p85 protein complex in NF2-related tumors.". International Journal of Oncology 12, no. 5 (1998): 1073-1081. https://doi.org/10.3892/ijo.12.5.1073