Fibroblast growth factor-2 and -9 regulate proliferation and production of matrix metalloproteinases in human gliomas. (original) (raw)

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• Authors:

  • N Miyagi
  • S Kato
  • M Terasaki
  • M Shigemori
  • M Morimatsu

• View Affiliations
  Affiliations: Department of Pathology, Kurume University, School of Medicine, Japan.

• Published online on: May 1, 1998 https://doi.org/10.3892/ijo.12.5.1085

• Pages: 1085-1175

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Abstract

Fibroblast growth factor (FGF) signaling has been recognized in human gliomas. We tested the effect of FGF-2 and FGF-9 on the proliferation and the expression of matrix metalloproteinases (MMPs) and their inhibitor (TIMP-1) in vitro. Both FGFs showed mitogenic activity on U251MG and NMC-G1 cells. MMP-1 expression and collagenolytic activity of NMC-G1 but not of U251MG, and TIMP-1 expression of both cells were stimulated by FGFs. MMP-2 expression, gelatinolytic activity, and chemoinvasion on the matrigel were not altered. FGFs may regulate proliferation and microenvironmental factors independently in each glioma type.

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• Impact Factor: 4.5
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• CiteScore: 9.6
• CiteScore Rank: Q1: #66/404 Oncology
• Source Normalized Impact per Paper (SNIP): 0.88
• SCImago Journal Rank (SJR): 1.099

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Spandidos Publications style

Miyagi N, Kato S, Terasaki M, Shigemori M and Morimatsu M: Fibroblast growth factor-2 and -9 regulate proliferation and production of matrix metalloproteinases in human gliomas.. Int J Oncol 12: 1085-1175, 1998.

APA

Miyagi, N., Kato, S., Terasaki, M., Shigemori, M., & Morimatsu, M. (1998). Fibroblast growth factor-2 and -9 regulate proliferation and production of matrix metalloproteinases in human gliomas.. International Journal of Oncology, 12, 1085-1175. https://doi.org/10.3892/ijo.12.5.1085

MLA

Miyagi, N., Kato, S., Terasaki, M., Shigemori, M., Morimatsu, M."Fibroblast growth factor-2 and -9 regulate proliferation and production of matrix metalloproteinases in human gliomas.". International Journal of Oncology 12.5 (1998): 1085-1175.

Chicago

Miyagi, N., Kato, S., Terasaki, M., Shigemori, M., Morimatsu, M."Fibroblast growth factor-2 and -9 regulate proliferation and production of matrix metalloproteinases in human gliomas.". International Journal of Oncology 12, no. 5 (1998): 1085-1175. https://doi.org/10.3892/ijo.12.5.1085