Mutation analysis of the putative tumor suppressor PTEN/MMAC1 in human ovarian cancer. (original) (raw)

• Home

• Submit Manuscript

• My Account

• Authors:

  • A Yokomizo
  • D J Tindall
  • L Hartmann
  • R B Jenkins
  • D I Smith
  • W Liu

• View Affiliations
  Affiliations: Division of Experimental Pathology, Department of Laboratory Medicine and Pathology and Department of Urology Research, Mayo Clinic/Foundation, Rochester, MN 55905, USA.

• Published online on: July 1, 1998 https://doi.org/10.3892/ijo.13.1.101

• Pages: 101-106

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

This article is mentioned in:

Abstract

A putative tumor suppressor, PTEN/MMAC1 gene was recently identified at 10q23 and was found to be frequently altered in several types of human tumors. To determine the possible role of this gene in human ovarian tumors, we screened 31 unselected primary epithelial ovarian cancers with matched normal tissues and 7 ovarian cancer cell lines. Two homozygous deletions (4.8%) were detected in primary ovarian tumors by a semi-quantitative multiplex polymerase chain reaction. However, no point mutations were observed in any of the PTEN/MMAC1 coding sequences as determined by denaturing high-performance liquid chromatography and DNA sequencing. These data indicate that PTEN/MMAC1 mutations are rare in ovarian cancers.

Related Articles

• View Abstract
• Cite This Article
• Download Citation
• Create Citation Alert
• Remove Citation Alert
• Cited By
• on Spandidos Publications
• on Google Scholar
• on Pub Med
• © Get Permissions
• Impact Factor: 4.5
• Ranked Oncology
  (total number of cites)
• CiteScore: 9.6
• CiteScore Rank: Q1: #66/404 Oncology
• Source Normalized Impact per Paper (SNIP): 0.88
• SCImago Journal Rank (SJR): 1.099

Copy and paste a formatted citation

Spandidos Publications style

Yokomizo A, Tindall D, Hartmann L, Jenkins R, Smith D and Liu W: Mutation analysis of the putative tumor suppressor PTEN/MMAC1 in human ovarian cancer.. Int J Oncol 13: 101-106, 1998.

APA

Yokomizo, A., Tindall, D., Hartmann, L., Jenkins, R., Smith, D., & Liu, W. (1998). Mutation analysis of the putative tumor suppressor PTEN/MMAC1 in human ovarian cancer.. International Journal of Oncology, 13, 101-106. https://doi.org/10.3892/ijo.13.1.101

MLA

Yokomizo, A., Tindall, D., Hartmann, L., Jenkins, R., Smith, D., Liu, W."Mutation analysis of the putative tumor suppressor PTEN/MMAC1 in human ovarian cancer.". International Journal of Oncology 13.1 (1998): 101-106.

Chicago

Yokomizo, A., Tindall, D., Hartmann, L., Jenkins, R., Smith, D., Liu, W."Mutation analysis of the putative tumor suppressor PTEN/MMAC1 in human ovarian cancer.". International Journal of Oncology 13, no. 1 (1998): 101-106. https://doi.org/10.3892/ijo.13.1.101