Spandidos Publications: International Journal of Oncology (original) (raw)

Article

High fat diet enhances colonic cell proliferation and carcinogenesis in rats by elevating serum leptin

• Authors:
  • Z. Liu
  • T. Uesaka
  • H. Watanabe
  • N. Kato
• View Affiliations / Copyright
  Affiliations: Department of Applied Biochemistry, Faculty of Applied Biological Science, Hiroshima University, Higashi-Hiroshima 739-8528, Japan
• Pages: 1009-1014
  |
  Published online on: November 1, 2001
  https://doi.org/10.3892/ijo.19.5.1009
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Abstract

We postulated that high fat diet enhances colon cell proliferation and carcinogenesis by elevating serum leptin. To examine this possibility, the present study was conducted to investigate the effect of leptin on the growth of human colon cancer cells (HT29) and the relationship between serum leptin and colon cell proliferation and aberrant crypt foci (ACF) in the 1,2-dimethylhydrazine-treated rats fed graded levels of dietary fat for 28 days. In cell culture experiments, leptin stimulated the growth and proliferation (BrdU incorporation) of colon cancer cells and the expression of c-fos protein. In the in vivo experiments, an elevation of dietary fat caused higher serum leptin and adipose-tissue weight. Colonic cell proliferation (BrdU incorporation), c-fos protein expression and ACF were elevated with increasing dietary fat. There was a significant correlation between serum concentration of leptin and colon cell proliferation and ACF. The results suggest that the enhancement of colon cell proliferation and carcinogenesis by high fat diet is mediated through elevating serum leptin.

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Spandidos Publications style

Liu Z, Uesaka T, Watanabe H and Kato N: High fat diet enhances colonic cell proliferation and carcinogenesis in rats by elevating serum leptin. Int J Oncol 19: 1009-1014, 2001.

APA

Liu, Z., Uesaka, T., Watanabe, H., & Kato, N. (2001). High fat diet enhances colonic cell proliferation and carcinogenesis in rats by elevating serum leptin. International Journal of Oncology, 19, 1009-1014. https://doi.org/10.3892/ijo.19.5.1009

MLA

Liu, Z., Uesaka, T., Watanabe, H., Kato, N."High fat diet enhances colonic cell proliferation and carcinogenesis in rats by elevating serum leptin". International Journal of Oncology 19.5 (2001): 1009-1014.

Chicago

Liu, Z., Uesaka, T., Watanabe, H., Kato, N."High fat diet enhances colonic cell proliferation and carcinogenesis in rats by elevating serum leptin". International Journal of Oncology 19, no. 5 (2001): 1009-1014. https://doi.org/10.3892/ijo.19.5.1009