ABSENCE OF SOMATIC MUTATIONS IN THE CODING REGION OF THE WAF1/CIP1 GENE IN HUMAN BREAST, LUNG AND OVARIAN CARCINOMAS - A POLYMORPHISM AT CODON-31 (original) (raw)
Authors:
- A MARCHETTI
- F BUTTITTA
- S PELLEGRINI
- G BERTACCA
- A LORI
- G BEVILACQUA
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Affiliations: Affliations not specifiedPublished online on: January 1, 1995 https://doi.org/10.3892/ijo.6.1.187
Pages: 187-189
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Abstract
Seventy-four invasive ductal, breast carcinomas, 73 non-small cell lung carcinomas and 36 ovarian adenocarcinomas, obtained from 183 unrelated patients, were investigated for mutations in the WAF1/CIP1 coding sequence by reverse transcriptase-polymerase chain reaction-single strand conformation polymorphism analysis. No somatic mutations were present in the WAF1/CIP1 open reading frame (ORF) in tumor samples. A polymorphism at codon 31 was observed in 16 (8.7%) cancer patients and in 9 (8.8%) of 102 unrelated normal individuals. The polymorphic allele changes the codon 31 AGC to AGA, thus implying an aminoacid substitution from serine to arginine, and creates a Hga-1 restriction site which might be useful for deletion studies. The polymorphism was present in the heterozygous state, except for the case of a 70-year-old male lung cancer patient who was homozygous: Our results indicate that the coding region of WAF1/CIP1 is not a frequent target for somatic mutations in breast, lung and ovarian cancer.
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Spandidos Publications style
MARCHETTI A, BUTTITTA F, PELLEGRINI S, BERTACCA G, LORI A and BEVILACQUA G: ABSENCE OF SOMATIC MUTATIONS IN THE CODING REGION OF THE WAF1/CIP1 GENE IN HUMAN BREAST, LUNG AND OVARIAN CARCINOMAS - A POLYMORPHISM AT CODON-31. Int J Oncol 6: 187-189, 1995.
APA
MARCHETTI, A., BUTTITTA, F., PELLEGRINI, S., BERTACCA, G., LORI, A., & BEVILACQUA, G. (1995). ABSENCE OF SOMATIC MUTATIONS IN THE CODING REGION OF THE WAF1/CIP1 GENE IN HUMAN BREAST, LUNG AND OVARIAN CARCINOMAS - A POLYMORPHISM AT CODON-31. International Journal of Oncology, 6, 187-189. https://doi.org/10.3892/ijo.6.1.187
MLA
MARCHETTI, A., BUTTITTA, F., PELLEGRINI, S., BERTACCA, G., LORI, A., BEVILACQUA, G."ABSENCE OF SOMATIC MUTATIONS IN THE CODING REGION OF THE WAF1/CIP1 GENE IN HUMAN BREAST, LUNG AND OVARIAN CARCINOMAS - A POLYMORPHISM AT CODON-31". International Journal of Oncology 6.1 (1995): 187-189.
Chicago
MARCHETTI, A., BUTTITTA, F., PELLEGRINI, S., BERTACCA, G., LORI, A., BEVILACQUA, G."ABSENCE OF SOMATIC MUTATIONS IN THE CODING REGION OF THE WAF1/CIP1 GENE IN HUMAN BREAST, LUNG AND OVARIAN CARCINOMAS - A POLYMORPHISM AT CODON-31". International Journal of Oncology 6, no. 1 (1995): 187-189. https://doi.org/10.3892/ijo.6.1.187