Spandidos Publications: Oncology Reports (original) (raw)

Article

The expression of high-mobility group protein box 1 correlates with the progression of non-small cell lung cancer

• Authors:
  • Xiaokun Shen
  • Lingzhi Hong
  • Huiming Sun
  • Minke Shi
  • Yong Song
• View Affiliations / Copyright
  Affiliations: Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, P.R. China
• Pages: 535-539
  |
  Published online on: September 1, 2009
  https://doi.org/10.3892/or\_00000468
• Expand metrics +

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

This article is mentioned in:

Abstract

High-mobility group protein box 1 (HMGB1) released from dying tumor cells promotes tumor progression, on the other hand HMGB1 activates dendritic cells and triggers anti-neoplastic response of T-cells in chemotherapy and radiotherapy. HMGB1 expression is up-regulated in many kinds of tumors. To investigate HMGB1 expression in non-small cell lung cancer, 63 patients were enrolled and tumor tissues were collected with matched normal lung tissues. HMGB1 mRNA and protein levels were quantified with real-time PCR, Western blots and immunohistochemistry. The HMGB1 expression in tumor tissue was lower than in matched normal lung tissue at mRNA levels (Paired t-test, t<0.001) and the down-regulation in stage III-IV patients was also significantly greater than one in stage I-II (one-way ANOVA, p=0.005). At protein level, HMGB1 expression was also down-regulated. Low HMGB1 expression in non-small cell lung cancer may explain the poor therapeutical outcome during chemotherapy and radiotherapy.

Related Articles

Copy and paste a formatted citation

Spandidos Publications style

Shen X, Hong L, Sun H, Shi M and Song Y: The expression of high-mobility group protein box 1 correlates with the progression of non-small cell lung cancer. Oncol Rep 22: 535-539, 2009.

APA

Shen, X., Hong, L., Sun, H., Shi, M., & Song, Y. (2009). The expression of high-mobility group protein box 1 correlates with the progression of non-small cell lung cancer. Oncology Reports, 22, 535-539. https://doi.org/10.3892/or\_00000468

MLA

Shen, X., Hong, L., Sun, H., Shi, M., Song, Y."The expression of high-mobility group protein box 1 correlates with the progression of non-small cell lung cancer". Oncology Reports 22.3 (2009): 535-539.

Chicago

Shen, X., Hong, L., Sun, H., Shi, M., Song, Y."The expression of high-mobility group protein box 1 correlates with the progression of non-small cell lung cancer". Oncology Reports 22, no. 3 (2009): 535-539. https://doi.org/10.3892/or\_00000468