Spandidos Publications: Oncology Reports (original) (raw)

Print ISSN: 1021-335X Online ISSN: 1791-2431

Article

Role of autophagy in resistance to oxaliplatin in hepatocellular carcinoma cells

• Authors:
  • Hailei Du
  • Weiping Yang
  • Lin Chen
  • Mingming Shi
  • Varun Seewoo
  • Jiayu Wang
  • Andy Lin
  • Zhuoran Liu
  • Weihua Qiu
• View Affiliations / Copyright
  Affiliations: 1Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China, Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Er Road, Shanghai 200025, P.R. China
• Pages: 143-150
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  Published online on: September 20, 2011
  https://doi.org/10.3892/or.2011.1464
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Abstract

In spite of an initially promising anti-tumor activity, oxaliplatin-based combinatorial treatments can eventually result in a tumor resistance response. In this study we aimed to understand the role of autophagy in HCC cell resistance to oxaliplatin and to discuss its potential therapeutic implication. We found that exposure to oxaliplatin induced a significant increase in LC3 lipidation and subsequent LC3 puncta formation. While the proliferation of HCC cells was inhibited upon oxaliplatin exposure, inhibition of autophagy by ATG7 interference and chloroquine pre-treatment further increased the sensitivity to chemotherapy. Meanwhile, the oxaliplatin-induced apoptotic cell death was significantly enhanced. These results suggest that autophagy may function importantly in HepG2 cell resistance to oxaliplatin. Intriguingly, the resistance could be recovered apparently by inhibition of autophagy. This also points to the potential therapy for hepatoma by perturbing autophagy.

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Spandidos Publications style

Du H, Yang W, Chen L, Shi M, Seewoo V, Wang J, Lin A, Liu Z and Qiu W: Role of autophagy in resistance to oxaliplatin in hepatocellular carcinoma cells. Oncol Rep 27: 143-150, 2012.

APA

Du, H., Yang, W., Chen, L., Shi, M., Seewoo, V., Wang, J. ... Qiu, W. (2012). Role of autophagy in resistance to oxaliplatin in hepatocellular carcinoma cells. Oncology Reports, 27, 143-150. https://doi.org/10.3892/or.2011.1464

MLA

Du, H., Yang, W., Chen, L., Shi, M., Seewoo, V., Wang, J., Lin, A., Liu, Z., Qiu, W."Role of autophagy in resistance to oxaliplatin in hepatocellular carcinoma cells". Oncology Reports 27.1 (2012): 143-150.

Chicago

Du, H., Yang, W., Chen, L., Shi, M., Seewoo, V., Wang, J., Lin, A., Liu, Z., Qiu, W."Role of autophagy in resistance to oxaliplatin in hepatocellular carcinoma cells". Oncology Reports 27, no. 1 (2012): 143-150. https://doi.org/10.3892/or.2011.1464