| [Jin Kyeong Park](/articles/search%5Fresult.php?term=author&f%5Fname=Jin Kyeong&l%5Fname=Park), [Won Jung Koh](/articles/search%5Fresult.php?term=author&f%5Fname=Won Jung&l%5Fname=Koh), [Deog Kyeom Kim](/articles/search%5Fresult.php?term=author&f%5Fname=Deog Kyeom&l%5Fname=Kim), [Eun Kyung Kim](/articles/search%5Fresult.php?term=author&f%5Fname=Eun Kyung&l%5Fname=Kim), [Yu Il Kim](/articles/search%5Fresult.php?term=author&f%5Fname=Yu Il&l%5Fname=Kim), [Hee Jin Kim](/articles/search%5Fresult.php?term=author&f%5Fname=Hee Jin&l%5Fname=Kim), [Tae Hyung Kim](/articles/search%5Fresult.php?term=author&f%5Fname=Tae Hyung&l%5Fname=Kim), [Jae Yeol Kim](/articles/search%5Fresult.php?term=author&f%5Fname=Jae Yeol&l%5Fname=Kim), [Moo Suk Park](/articles/search%5Fresult.php?term=author&f%5Fname=Moo Suk&l%5Fname=Park), [I Nae Park](/articles/search%5Fresult.php?term=author&f%5Fname=I Nae&l%5Fname=Park), [Jae Seuk Park](/articles/search%5Fresult.php?term=author&f%5Fname=Jae Seuk&l%5Fname=Park), [Ki Man Lee](/articles/search%5Fresult.php?term=author&f%5Fname=Ki Man&l%5Fname=Lee), [Sook Hee Song](/articles/search%5Fresult.php?term=author&f%5Fname=Sook Hee&l%5Fname=Song), [Jin Hwa Lee](/articles/search%5Fresult.php?term=author&f%5Fname=Jin Hwa&l%5Fname=Lee), [Seung Heon Lee](/articles/search%5Fresult.php?term=author&f%5Fname=Seung Heon&l%5Fname=Lee), [Hyuk Pyo Lee](/articles/search%5Fresult.php?term=author&f%5Fname=Hyuk Pyo&l%5Fname=Lee), [Jae Joon Yim](/articles/search%5Fresult.php?term=author&f%5Fname=Jae Joon&l%5Fname=Yim), Jaemin Lim, [Yang Jin Jegal](/articles/search%5Fresult.php?term=author&f%5Fname=Yang Jin&l%5Fname=Jegal), [Ki Hwan Jung](/articles/search%5Fresult.php?term=author&f%5Fname=Ki Hwan&l%5Fname=Jung), [Jin Won Huh](/articles/search%5Fresult.php?term=author&f%5Fname=Jin Won&l%5Fname=Huh), [Jae Chol Choi](/articles/search%5Fresult.php?term=author&f%5Fname=Jae Chol&l%5Fname=Choi), [Tae Sun Shim](/articles/search%5Fresult.php?term=author&f%5Fname=Tae Sun&l%5Fname=Shim) |
| 1Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. shimts@amc.seoul.kr 2Korean TB Study Group, Korean Academy of Tuberculosis and Respiratory Diseases, Seoul, Korea. 3Department of Pulmonary and Critical Care Medicine, Ewha Womans University School of Medicine, Seoul, Korea. |
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| Abstract |
| BACKGROUNDThe increasing rate of drug-resistant tuberculosis (TB) is a threat to the public health and TB control. In Korea, about 75~80% of TB patients are treated in private hospitals and the rate has been continuously increasing since 2000. METHODS: On a retrospective basis, we enrolled 170 newly diagnosed with or retreated for multidrug-resistant TB (MDR-TB) in 2004 from 21 private hospitals. We extracted the following demographics and treatment history from patient medical records: initial treatment outcomes, cumulative survival rates, treatment outcomes, and prognostic factors. RESULTS: Of the 170 patients, the majority were male (64.1%), the mean age was 44.5 years old, and mean body-mass-index was 20.2 kg/m2. None of the patients tested positive for HIV. Eleven (6.5%) were confirmed to have extensively drug-resistant TB (XDR-TB) at treatment initiation. Treatment success rates were not different between XDR-TB (36.4%, 4/11) and non-XDR MDR-TB (51.6%, 82/159). Default rate was high, 21.8% (37/170). Far advanced disease on X-ray was a significant negative predictor of treatment success; advanced disease and low BMI were risk factors for all-cause mortality. CONCLUSION: In private hospitals in Korea, the proportion of XDR-TB in MDR-TB was comparable to previous data. The treatment success rate of MDR-/XDR-TB remains poor and the failure rate was quite high. Adequate TB control policies should be strengthened to prevent the further development and spread of MDR-/XDR-TB in Korea. |
| Key Words: Tuberculosis, Multidrug-Resistant, Extensively Drug-Resistant Tuberculosis, Korea, Hospitals, Private |