Tumor-Infiltrating Dendritic Cells Are Potent Antigen-Presenting Cells Able to Activate T Cells and Mediate Tumor Rejection1 (original) (raw)
Journal Article
Louis Jeantet Skin Cancer Laboratory, Department of Pathology and Immunology, Geneva University Medical Center
,
Geneva
,
Switzerland
Department of Dermatology, Geneva University Hospital
,
Geneva
,
Switzerland
Address correspondence and reprint requests to Dr. Olivier Preynat-Seauve, Skin Cancer Laboratory, Department of Pathology and Immunology, Geneva University Medical Center, 1, rue Michel Servet, CH-1211, Geneva, Switzerland. E-mail address: [email protected]
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Louis Jeantet Skin Cancer Laboratory, Department of Pathology and Immunology, Geneva University Medical Center
,
Geneva
,
Switzerland
Department of Dermatology, Geneva University Hospital
,
Geneva
,
Switzerland
Search for other works by this author on:
Louis Jeantet Skin Cancer Laboratory, Department of Pathology and Immunology, Geneva University Medical Center
,
Geneva
,
Switzerland
Department of Dermatology, Geneva University Hospital
,
Geneva
,
Switzerland
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Institut Suisse de Recherches Experimentales sur le Cancer, Swiss Institute for Experimental Cancer Research
,
Epalinges
,
Switzerland
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Louis Jeantet Skin Cancer Laboratory, Department of Pathology and Immunology, Geneva University Medical Center
,
Geneva
,
Switzerland
Department of Dermatology, Geneva University Hospital
,
Geneva
,
Switzerland
Search for other works by this author on:
Louis Jeantet Skin Cancer Laboratory, Department of Pathology and Immunology, Geneva University Medical Center
,
Geneva
,
Switzerland
Department of Dermatology, Geneva University Hospital
,
Geneva
,
Switzerland
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Accepted:
11 October 2005
Published:
01 January 2006
Cite
Olivier Preynat-Seauve, Prisca Schuler, Emmanuel Contassot, Friedrich Beermann, Bertrand Huard, Lars E French, Tumor-Infiltrating Dendritic Cells Are Potent Antigen-Presenting Cells Able to Activate T Cells and Mediate Tumor Rejection, The Journal of Immunology, Volume 176, Issue 1, January 2006, Pages 61–67, https://doi.org/10.4049/jimmunol.176.1.61
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Abstract
Dendritic cells (DC) are potent inducers of immune responses. DC have been shown to infiltrate tumors, but very little is known about the functional status of these naturally occurring tumor-infiltrating DC (TIDC). In this study, the status and function of TIDC from several types of mouse melanoma were investigated in detail. CD11c+/MHC II+ cells, consistent with a DC phenotype, were found in all of transplantable or spontaneous melanomas studied. These TIDC were predominantly myeloid (CD11c+/CD8α−/B220−) in nature with small numbers of plasmacytoid (CD11c+/B220+). TIDC had an intermediate maturation phenotype with some expression of costimulatory molecules and the capacity to take up particles. Upon culture overnight ex vivo, the TIDC markedly up-regulated the expression of costimulatory molecules and also increased IL-12 production. Importantly, such ex vivo-matured TIDC pulsed with OVA were able to migrate to lymph nodes, to activate naive OVA-specific CD4+ and CD8+ T cells, and to confer protection against a challenge with OVA-expressing tumor cells. In conclusion, melanomas are infiltrated by functional DC that can act as fully competent APC. These APC have the potential to be manipulated and may therefore represent a promising target for cancer immunotherapy.
Copyright © 2006 by The American Association of Immunologists
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