New Insights Into Genetics and Pathophysiology of Alzheimer's Disease: What Are the Clinical and Therapeutic Implications? (original) (raw)
The Journal of Clinical Psychiatry
Academic Highlights September 30, 2000
Ravi Anand, M.D.; Michael Mullan, M.D.; George Grossberg, M.D.; Albert Enz, M.D.
J Clin Psychiatry 2000;61(4):307-315
Article Abstract
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Genetic findings have made an important contribution to the understanding of Alzheimer’s disease. The mutations in β-amyloid precursor protein (βAPP) and presenilin 1 (PS1) transmitted in a simple Mendelian manner have provided the basis for our understanding of the central role of β-amyloid in all cases of Alzheimer’s . Dr. Mullan suggested that whereas variability at the apolipoprotein E (APOE) locus is clearly associated with the occurrence of disease, for many other genes such clarity is less established.
About the Authors
- Ravi Anand, M.D. View full profile
- Michael Mullan, M.D. View full profile
- George Grossberg, M.D. View full profile
- Albert Enz, M.D. View full profile
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