Diabetes & Metabolism Journal (original) (raw)

Fig. 1. Trade-offs with insufficient and excessive circulating insulin levels. "Updated on 30 July 2021"

Fig. 2. Possible cellular targets of hyperinsulinemia in pancreatic cancer. (A) Violin plot showing insulin receptor (Insr) expression in pancreatic cells and immune cells. The data is based on single-cell gene expression analysis of mouse pancreas in Ptf1aCreER; LSL-KrasG12D; Ins1−/− genetic background generated using 10x Genomics. Background mRNA contamination was cleaned by R packages SoupX and the single-cell gene expression data was analyzed by Seurat 4.0 (Satija Lab). (B) Possible cellular targets of hyperinsulinemia in pancreatic cancer initiation and/or progression.

Fig. 3. Multiple links between insulin signaling and breast cancer. Insulin/Igf1 receptor signaling interacts with master regulators of breast cancer cell fate, including estrogen receptor signaling, core cell-cycle regulators, and metabolism. Virtually all proteins in this signaling network are regulated by phosphorylation. RTK, receptor tyrosine kinase; Erbb2, proto-oncogene Neu/Her2; Fgfr, fibroblast growth factor receptor; Insr, insulin receptor; Esr1, estrogen receptor 1; Grb2, growth factor receptor-bound protein 2; Irs, insulin receptor substrate; PI3K, phosphoinositide 3-kinase; Tsc2, tuberous sclerosis complex 2; Pten, phosphatase and tensin homolog; Glut1, glucose transporter 1; Hk, hexokinase; mTORC, mammalian target of rapamycin complex; Erk, extracellular signal-regulated kinase; Tp53, tumor protein p53; Gsk3b, glycogen synthase kinase 3b; Hif1a, hypoxia-inducible factor 1a; Pfk, phosphofructokinase; Pk, pyruvate kinase; Cdkn1, cyclin-dependent kinase inhibitor-1; Ampk, AMP-activated protein kinase; Pgr, progesterone receptor; Foxm1, forkhead box M1; Ccnd1/3, cyclin-dependent kinase 1/3; Myc, myc oncogene; Foxo, forkhead family box O; Cdk, cyclin-dependent kinase; Rb, retinoblastoma; E2f1, E2F transcription factor 1.

Graphical abstract