CCL2 Chemokine as a Potential Biomarker for Prostate Cancer: A Pilot Study (original) (raw)

Fig. 1. Analysis of chemokine gene activity obtained with real-time quantitative polymerase chain reaction in tumor tissue compared to normal adjacent tissue in patients with prostate cancer. Vertical line, Tukey confidence interval for Hodges-Lehmann estimator; ●, lower and upper limit of the Tukey confidence interval; ▲, Hodges-Lehmann estimator of the median fold difference.

Fig. 2. Results from Pearson’s regression test for chemokine expression in prostate cancer samples and tumor grade or Gleason score. Presented as regression line (thick) and confidence borders (thin lines) with confidence p=0.95. p, p-value of the regression test; B, regression coefficient; r, Pearson’s correlation coefficient. Chemokine expression as fold difference obtained with real-time quantitative polymerase chain reaction.

Fig. 3. Chemokine concentration obtained with Luminex. Chemokines with significant differences between at least two samples are presented. Box-plot: Con, control serum; Pre, preoperative serum; Post, postoperative serum. Box: lower line, quartile Q1 (25%-quantile); middle line, median; upper line, Q3 (75%-quantile); aerials, extreme values; horizontal bracket, respective p-value of the concentration difference in Wilcoxon-matched-pairs or Wilcoxon-Mann-Whitney test.