- Drossman, DA (2016). Functional gastrointestinal disorders: history, pathophysiology, clinical features and Rome IV. Gastroenterology. 150, Array-1279.

- Lovell, RM, and Ford, AC (2012). Global prevalence of and risk factors for irritable bowel syndrome: a meta-analysis. Clin Gastroenterol Hepatol. 10, Array-721.

- Mearin, F, Mearin, F, and Chang, L (2016). Bowel disorders. Gastroenterology. 150, Array-1407.

- Van Oudenhove, L, Crowell, MD, and Drossman, DA (2016). Biopsychosocial aspects of functional gastrointestinal disorders: how central and environmental processes contribute to the development and expression of functional gastrointestinal disorders. Gastroenterology. 150, Array-1367.

- Lee, SP, Sung, IK, Kim, JH, Lee, SY, Park, HS, and Shim, CS (2015). The effect of emotional stress and depression on the prevalence of digestive diseases. J Neurogastroenterol Motil. 21, 273-282.

- Houghton, LA, Calvert, EL, Jackson, NA, Cooper, P, and Whorwell, PJ (2002). Visceral sensation and emotion: a study using hypnosis. Gut. 51, 701-704.

- Wilder-Smith, CH (2011). The balancing act: endogenous modulation of pain in functional gastrointestinal disorders. Gut. 60, 1589-1599.

- Bennett, EJ, Tennant, CC, Piesse, C, Badcock, CA, and Kellow, JE (1998). Level of chronic life stress predicts clinical outcome in irritable bowel syndrome. Gut. 43, 256-261.

- Coss-Adame, E, and Rao, SS (2014). Brain and gut interactions in irritable bowel syndrome: new paradigms and new understandings. Curr Gastroenterol Rep. 16, 379.

- Orand, A, Gupta, A, and Shih, W (2015). Catecholaminergic gene polymorphisms are associated with GI symptoms and morphological brain changes in irritable bowel syndrome. PLoS One. 10, e0135910.

- Komuro, H, Sato, N, and Sasaki, A (2016). Corticotropin-releasing hormone receptor 2 gene variants in irritable bowel syndrome. PLoS One. 11, e0147817.

- Qi, R, Liu, C, and Ke, J (2016). Abnormal amygdala resting-state functional connectivity in irritable bowel syndrome. AJNR Am J Neuroradiol. 37, 1139-1145.

- Sasaki, A, Sato, N, and Suzuki, N (2016). Associations between single-nucleotide polymorphisms in corticotropin-releasing hormone-related genes and irritable bowel syndrome. PLoS One. 11, e0149322.

- Schneck, AS, Anty, R, and Tran, A (2016). Increased prevalence of irritable bowel syndrome in a cohort of french morbidly obese patients candidate for bariatric surgery. Obes Surg. 26, 1525-1530.

- Thijssen, AY, Mujagic, Z, and Jonkers, DM (2016). Alterations in serotonin metabolism in the irritable bowel syndrome. Aliment Pharmacol Ther. 43, 272-282.

- Wong, RK, Van Oudenhove, L, Li, X, Cao, Y, Ho, KY, and Wilder-Smith, CH (2016). Visceral pain perception in patients with irritable bowel syndrome and healthy volunteers is affected by the MRI scanner environment. United European Gastroenterol J. 4, 132-141.

- Seminowicz, DA, Labus, JS, and Bueller, JA (2010). Regional gray matter density changes in brains of patients with irritable bowel syndrome. Gastroenterology. 139, Array-57.

- Jones, MP, Chey, WD, and Singh, S (2014). A biomarker panel and psychological morbidity differentiates the irritable bowel syndrome from health and provides novel pathophysiological leads. Aliment Pharmacol Ther. 39, 426-437.

- Fond, G, Loundou, A, and Hamdani, N (2014). Anxiety and depression comorbidities in irritable bowel syndrome (IBS): a systematic review and meta-analysis. Eur Arch Psychiatry Clin Neurosci. 264, 651-660.

- Wells, G, Shea, B, O’Connell, D, and Peterson, J (). The Newcastle-Ottawa Scale (NOS) for assessing the quality if nonrandomized studies in meta-analyses.
Available from: URL: http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp
- Berman, S, Suyenobu, B, and Naliboff, BD (2012). Evidence for alterations in central noradrenergic signaling in irritable bowel syndrome. Neuroimage. 63, 1854-1863.

- Choung, RS, Locke, GR, Zinsmeister, AR, Schleck, CD, and Talley, NJ (2009). Psychosocial distress and somatic symptoms in community subjects with irritable bowel syndrome: a psychological component is the rule. Am J Gastroenterol. 104, 1772-1779.

- Locke, GR, Weaver, AL, Melton, LJ, and Talley, NJ (2004). Psychosocial factors are linked to functional gastrointestinal disorders: a population based nested case-control study. Am J Gastroenterol. 99, 350-357.

- Boyce, PM, Koloski, NA, and Talley, NJ (2000). Irritable bowel syndrome according to varying diagnostic criteria: are the new Rome II criteria unnecessarily restrictive for research and practice?. Am J Gastroenterol. 95, 3176-3183.

- Pinto, C, Lele, MV, Joglekar, AS, Panwar, VS, and Dhavale, HS (2000). Stressful life-events, anxiety, depression and coping in patients of irritable bowel syndrome. J Assoc Physicians India. 48, 589-593.
- Su, YC, Wang, WM, and Wang, SY (2000). The association between Helicobacter pylori infection and functional dyspepsia in patients with irritable bowel syndrome. Am J Gastroenterol. 95, 1900-1905.

- Patacchioli, FR, Angelucci, L, Dellerba, G, Monnazzi, P, and Leri, O (2001). Actual stress, psychopathology and salivary cortisol levels in the irritable bowel syndrome (IBS). J Endocrinol Invest. 24, 173-177.

- Liebregts, T, Adam, B, and Bredack, C (2007). Immune activation in patients with irritable bowel syndrome. Gastroenterology. 132, 913-920.

- van der Veek, PP, Van Rood, YR, and Masclee, AA (2008). Symptom severity but not psychopathology predicts visceral hypersensitivity in irritable bowel syndrome. Clin Gastroenterol Hepatol. 6, 321-328.

- Savas, LS, White, DL, and Wieman, M (2009). Irritable bowel syndrome and dyspepsia among women veterans: prevalence and association with psychological distress. Aliment Pharmacol Ther. 29, 115-125.

- Shen, L, Kong, H, and Hou, X (2009). Prevalence of irritable bowel syndrome and its relationship with psychological stress status in Chinese university students. J Gastroenterol Hepatol. 24, 1885-1890.

- Elsenbruch, S, Rosenberger, C, Enck, P, Forsting, M, Schedlowski, M, and Gizewski, ER (2010). Affective disturbances modulate the neural processing of visceral pain stimuli in irritable bowel syndrome: an fMRI study. Gut. 59, 489-495.

- Heymen, S, Maixner, W, Whitehead, WE, Klatzkin, RR, Mechlin, B, and Light, KC (2010). Central processing of noxious somatic stimuli in patients with irritable bowel syndrome compared with healthy controls. Clin J Pain. 26, 104-109.

- Jerndal, P, Ringström, G, and Agerforz, P (2010). Gastrointestinal-specific anxiety: an important factor for severity of GI symptoms and quality of life in IBS. Neurogastroenterol Motil. 22, 646-e179.

- Piche, T, Ducrotté, P, and Sabate, JM (2010). Impact of functional bowel symptoms on quality of life and fatigue in quiescent Crohn disease and irritable bowel syndrome. Neurogastroenterol Motil. 22, 626-e174.

- Tosic-Golubovic, S, Miljkovic, S, Nagorni, A, Lazarevic, D, and Nikolic, G (2010). Irritable bowel syndrome, anxiety, depression and personality characteristics. Psychiatr Danub. 22, 418-424.

- Cho, HS, Park, JM, and Lim, CH (2011). Anxiety, depression and quality of life in patients with irritable bowel syndrome. Gut Liver. 5, 29-36.

- Goncalves de Medeiros, MT, de Oliveira, RB, and dos Santos, AA (2012). The effects of sildenafil on rectal sensitivity and tone in patients with the irritable bowel syndrome. Aliment Pharmacol Ther. 35, 577-586.

- Hartono, JL, Mahadeva, S, and Goh, KL (2012). Anxiety and depression in various functional gastrointestinal disorders: do differences exist?. J Dig Dis. 13, 252-257.

- Lee, HF, Hsieh, JC, and Lu, CL (2012). Enhanced affect/cognition-related brain responses during visceral placebo analgesia in irritable bowel syndrome patients. Pain. 153, 1301-1310.

- Kabra, N, and Nadkarni, A (2013). Prevalence of depression and anxiety in irritable bowel syndrome: a clinic based study from India. Indian J Psychiatry. 55, 77-80.

- Park, JH, Rhee, PL, and Kim, HS (2006). Mucosal mast cell counts correlate with visceral hypersensitivity in patients with diarrhea predominant irritable bowel syndrome. J Gastroenterol Hepatol. 21, 71-78.

- Uz, E, Türkay, C, Aytac, S, and Bavbek, N (2007). Risk factors for irritable bowel syndrome in Turkish population: role of food allergy. J Clin Gastroenterol. 41, 380-383.

- Kohen, R, Tracy, JH, Haugen, E, Cain, KC, Jarrett, ME, and Heitkemper, MM (2016). Rare variants of the serotonin transporter are associated with psychiatric comorbidity in irritable bowel syndrome. Biol Res Nurs. 18, 394-400.

- Pinto-Sanchez, MI, Ford, AC, and Avila, CA (2015). Anxiety and depression increase in a stepwise manner in parallel with multiple FGIDs and symptom severity and frequency. Am J Gastroenterol. 110, 1038-1048.

- Mujagic, Z, Ludidi, S, and Keszthelyi, D (2014). Small intestinal permeability is increased in diarrhoea predominant IBS, while alterations in gastroduodenal permeability in all IBS subtypes are largely attributable to confounders. Aliment Pharmacol Ther. 40, 288-297.

- Sugaya, N, Nomura, S, and Shimada, H (2012). Relationship between cognitive factors and anxiety in individuals with irritable bowel syndrome. Int J Behav Med. 19, 308-315.

- Hod, K, Ringel-Kulka, T, Martin, CF, Maharshak, N, and Ringel, Y (2016). High-sensitive C-reactive protein as a marker for inflammation in irritable bowel syndrome. J Clin Gastroenterol. 50, 227-232.

- Eriksson, EM, Andrén, KI, Eriksson, HT, and Kurlberg, GK (2008). Irritable bowel syndrome subtypes differ in body awareness, psychological symptoms and biochemical stress markers. World J Gastroenterol. 14, 4889-4896.

- Keszthelyi, D, Troost, FJ, Jonkers, DM, Kruimel, JW, Leue, C, and Masclee, AA (2013). Decreased levels of kynurenic acid in the intestinal mucosa of IBS patients: relation to serotonin and psychological state. J Psychosom Res. 74, 501-504.

- Grasberger, H, Chang, L, and Shih, W (2013). Identification of a functional TPH1 polymorphism associated with irritable bowel syndrome bowel habit subtypes. Am J Gastroenterol. 108, 1766-1774.

- Bouchoucha, M, Hejnar, M, Devroede, G, Boubaya, M, Bon, C, and Benamouzig, R (2014). Patients with irritable bowel syndrome and constipation are more depressed than patients with functional constipation. Dig Liver Dis. 46, 213-218.

- Kanuri, N, Cassell, B, and Bruce, SE (2016). The impact of abuse and mood on bowel symptoms and health-related quality of life in irritable bowel syndrome (IBS). Neurogastroenterol Motil. 28, 1508-1517.

- Padhy, SK, Mishra, S, Sarkar, S, Bang, LG, and Panigrahi, M (2016). Comparison of psychiatric morbidity in patients with irritable bowel syndrome and non-ulcer dyspepsia. Ind Psychiatry J. 25, 29-34.

- Roohafza, H, Bidaki, EZ, Hasanzadeh-Keshteli, A, Daghaghzade, H, Afshar, H, and Adibi, P (2016). Anxiety, depression and distress among irritable bowel syndrome and their subtypes: an epidemiological population based study. Adv Biomed Res. 5, 183.

- Gao, J (2013). Correlation between anxiety-depression status and cytokines in diarrhea-predominant irritable bowel syndrome. Exp Ther Med. 6, 93-96.

- Dunlop, SP, Jenkins, D, and Spiller, RC (2003). Distinctive clinical, psychological, and histological features of postinfective irritable bowel syndrome. Am J Gastroenterol. 98, 1578-1583.

- Motzer, SA, Hertig, V, Jarrett, M, and Heitkemper, MM (2003). Sense of coherence and quality of life in women with and without irritable bowel syndrome. Nurs Res. 52, 329-337.

- Lee, KJ, Kim, YB, Kim, JH, Kwon, HC, Kim, DK, and Cho, SW (2008). The alteration of enterochromaffin cell, mast cell, and lamina propria T lymphocyte numbers in irritable bowel syndrome and its relationship with psychological factors. J Gastroenterol Hepatol. 23, 1689-1694.

- Hamaguchi, T, Fukudo, S, and Kanazawa, M (2008). Changes in salivary physiological stress markers induced by muscle stretching in patients with irritable bowel syndrome. Biopsychosoc Med. 2, 20.

- Akkuş, S, Senol, A, Ayvacioglu, NB, Tunc, E, Eren, I, and Isler, M (2004). Is female predominance in irritable bowel syndrome related to fibromyalgia?. Rheumatol Int. 24, 106-109.

- Dancey, CP, Attree, EA, Stuart, G, Wilson, C, and Sonnet, A (2009). Words fail me: the verbal IQ deficit in inflammatory bowel disease and irritable bowel syndrome. Inflamm Bowel Dis. 15, 852-857.

- Sato, N, Suzuki, N, and Sasaki, A (2012). Corticotropin-releasing hormone receptor 1 gene variants in irritable bowel syndrome. PLoS One. 7, e42450.

- Qi, R, Liu, C, and Ke, J (2016). Intrinsic brain abnormalities in irritable bowel syndrome and effect of anxiety and depression. Brain Imaging Behav. 10, 1127-1134.

- Camilleri, M, McKinzie, S, and Busciglio, I (2008). Prospective study of motor, sensory, psychologic, and autonomic functions in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol. 6, 772-781.

- Cusin, C, Yang, H, Yeung, A, and Fava, M (2009). Rating scales for depression. Handbook of clinical rating scales and assessment in psychiatry and mental health: Springer, pp. 7-35

- Lewis-Fernández, R, Hinton, DE, and Laria, AJ (2010). Culture and the anxiety disorder: recommendations for DSM-V. Depress Anxiety. 27, 212-229.

- Fang, X, Francisconi, CF, and Fukudo, S (2016). Multicultural aspects in functional gastrointestinal disorders (FGIDs). Gastroenterology. 150, 1344-1354.e2.

- Palsson, OS, Whitehead, WE, and van Tilburg, MAL (2016). Development and validation of the Rome IV diagnostic questionnaire for adults. Gastroenterology. 150, 1481-1491.

- Steel, Z, Marnane, C, and Iranpour, C (2014). The global prevalence of common mental disorders: a systematic review and meta-analysis 1980–2013. Int J Epidemiol. 3, 476-493.

- Rai, D, Zitko, P, Jones, K, Lynch, J, and Araya, R (2013). Country- and individual-level socioeconomic determinants of depression: multilevel cross-national comparison. Br J Psychiatry. 202, 195-203.

- Steel, Z, Silove, D, and Giao, NM (2009). International and indigenous diagnoses of mental disorder among Vietnamese living in Vietnam and Australia. Br J Psychiatry. 194, 326-333.

- Houghton, LA, Heitkemper, M, and Crowell, M (2016). Age, gender and women’s health and the patient. Gastroenterology. 150, Array-1343.

- Spiller, R (2008). Serotonin and GI clinical disorders. Neuropharmacology. 55, 1072-1080.

- Muscatello, MR, Bruno, A, and Pandolfo, G (2010). Depression, anxiety and anger in subtypes of irritable bowel syndrome patients. J Clin Psychol Med Settings. 17, 64-70.
