A human endogenous retroviral superantigen as candidate autoimmune gene in type I diabetes. (original) (raw)

Abstract

Microbial superantigens (SAGs) have been implicated in the pathogenesis of human autoimmune diseases. Preferential expansion of the Vveta7 T cell receptor positive T cell subset in patients suffering from acute-onset type I diabetes has indicated the presence of a surface membrane-bound SAG. Here, we have isolated a novel mouse mammary tumor virus-related human endogenous retrovirus. We further show that the N-terminal moiety of the envelope gene encodes an MHC class II-dependent SAG. We propose that expression of this SAG, induced in

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128 since deposited on 2008-02-11

Acq. date: 2025-11-13

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141 since deposited on 2008-02-11

Acq. date: 2025-11-13

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Additional indexing

Creators (Authors)

Journal/Series Title

Volume

Number

Page range/Item number

303

Page end

313

Item Type

Journal Article

Dewey Decimal Classifikation

Language

English

Publication date

1997-07-25

Date available

2008-02-11

Publisher

ISSN or e-ISSN

0092-8674

OA Status

Hybrid

Publisher DOI

PubMed ID

Metrics

Downloads

128 since deposited on 2008-02-11

Acq. date: 2025-11-13

Views

141 since deposited on 2008-02-11

Acq. date: 2025-11-13

Citations

Permanent URL

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Files available to download:1

Conrad_vor.pdfview fileDownload PDF|1Download869.08 KB