Seung Man Cho, M.D., Byung-Ho Choe, M.D., Mi Ae Chu, M.D. and Jung-Mi Kim, M.D.
Department of Pediatrics, Kyungpook National University School of Medicine, Daegu, Korea.
Received February 02, 2010; Accepted March 04, 2010.
Abstract
Purpose
To estimate the viral suppressive effect of entecavir monotherapy in Korean children and adolescents with lamivudine-resistant chronic hepatitis B (CHB).
Methods
One milligram of entecavir was administered once daily to 6 patients (4 boys; mean age, 17.5 years; range, 15.10~24.6 years) with lamivudine-resistant CHB for a mean duration of therapy of 13.4 months (range, 1~21.1 months). The therapeutic results were compared with 11 patients who received adefovir (0.3 mg/kg/day [maximal dose 10 mg]) for at least 12 months (mean, 33.4 months; range, 12.4~58.3 months). The serum HBV DNA level and serologic markers were measured every 2 months.
Results
The interval to a HBV DNA titer decrement (>1 log10) was 1.2±0.2 and 4.4±5.2 months (_p_=0.185) for the entecavir and adefovir groups, respectively. The interval to a HBV DNA titer decrement (>2 log10) was 2.4±2.3 and 9.2±7.3 months (_p_=0.025), for the entecavir and adefovir groups, respectively.
Conclusion
The therapeutic efficacy of entecavir was favorable in children and adolescents, especially in shortening the interval to a >2 log10 decrement in the HBV DNA titer. Long-term follow up is needed to determine the therapeutic efficacy of entecavir for lamivudine-resistant CHB in children and adolescents.
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