Actigraphy prior to Multiple Sleep Latency Test: nighttime total sleep time predicts sleep-onset latency (original) (raw)

Abstract

Study Objectives:

To evaluate the clinical utility of actigraphy as compared with sleep questionnaires prior to the Multiple Sleep Latency Test (MSLT) in a sleep disorders clinic population.

Methods:

Twenty-eight clinically referred participants (mean age: 42.3 ± 18.8 years) completed the study protocol. On day 1, participants completed the following questionnaires: Epworth Sleepiness Scale (ESS), Insomnia Severity Index, Pittsburgh Sleep Quality Index (PSQI), Visual Analog Scale (affect, vigor), Patient Health Questionnaire, and Multidimensional Fatigue Symptom Inventory–Short Form. On days 1–8, participants wore an actigraph and completed a sleep diary to assess mean nighttime and mean daytime total sleep time and sleep efficiency or sleep percentage. On day 9, participants repeated the ESS and completed an MSLT. Correlations assessed mean MSLT sleep-onset latency (MSLT-SOL) vs actigraphy, sleep diary, and questionnaires. Chi-square analyses assessed abnormal MSLT-SOL (≤ 8 minutes) or daytime sleepiness (ESS ≥ 10) and referral question (ie, sleep-disordered breathing vs hypersomnolence disorder).

Results:

Mean MSLT-SOL was correlated with nighttime total sleep time assessed via both actigraphy and diary, but not with questionnaires. Significant correlations emerged for ESS score on day 1 vs 9, actigraphy vs sleep diary mean nighttime total sleep time, and PSQI vs mean sleep diary sleep efficiency. There was no significant relationship between mean MSLT-SOL and referral question.

Conclusions:

Our finding that total sleep time measured by actigraphy was associated with MSLT-SOL suggests it is useful in informing the interpretation of MSLT findings; however, it does not appear to be a viable substitute for MSLT for the measurement of objective sleepiness in clinical settings.

Citation:

Kelly MR, Zeidler MR, DeCruz S, et al. Actigraphy prior to Multiple Sleep Latency Test: nighttime total sleep time predicts sleep-onset latency. J Clin Sleep Med. 2022;18(1):161–170.

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Abbreviations

AHI:

apnea-hypopnea index

CTRC:

UCLA Clinical Translational Research Center

ESS:

Epworth Sleepiness Scale

MFSI-sf:

Multidimensional Fatigue Symptom Inventory-Short Form

MSLT:

Multiple Sleep Latency Test

PHQ-9:

Patient Health Questionnaire–9 item

PSG:

polysomnography/polysomnogram

PSQI:

Pittsburgh Sleep Quality Index

SDB:

sleep-disordered breathing

SE:

sleep efficiency

SOL:

sleep-onset latency

TST:

total sleep time

UCLA:

University of California Los Angeles

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ACKNOWLEDGMENTS

The authors thank Claudia Perdomo, the UCLA Clinical Translational Research Center (CTRC), and the study participants for their contributions to this research. Author contributions: Kelly: analysis and interpretation of data; drafting the work or revising it critically; final approval of the version submitted for publication. M.R.Z.: conception and design; acquisition, analysis, and interpretation of data; drafting the work or revising it critically; final approval of the version submitted for publication. S.D.: acquisition and interpretation of data; drafting the work or revising it critically; final approval of the version submitted for publication. C.L.O.: acquisition and interpretation of data; drafting the work or revising it critically; final approval of the version submitted for publication. K.R.J.: conception and design; acquisition, analysis, and interpretation of data; drafting the work or revising it critically; final approval of the version submitted for publication. M.N.M.: conception and design; acquisition, analysis, and interpretation of data; drafting the work and revising it critically; final approval of the version submitted for publication. M.L.: interpretation of data; drafting the work and revising it critically; final approval of the version submitted for publication. S.A.-I.: interpretation of data; drafting the work and revising it critically; final approval of the version submitted for publication. M.S.B.: interpretation of data; drafting the work and revising it critically; final approval of the version submitted for publication. C.A.A.: conception and design; analysis and interpretation of data; drafting the work or revising it critically; final approval of the version submitted for publication. J.L.M.: conception and design; acquisition, analysis, and interpretation of data; drafting the work or revising it critically; final approval of the version submitted for publication.

Author information

Authors and Affiliations

  1. Veterans Affairs Greater Los Angeles Healthcare System, Geriatric Research, Education and Clinical Center, North Hills, California, USA
    Monica R. Kelly PhD, Karen R. Josephson MPH, Michael N. Mitchell PhD, Michael Littner MD, Cathy A. Alessi MD & Jennifer L. Martin PhD
  2. Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Michelle R. Zeidler MD, Sharon DeCruz MD, Michael Littner MD, Cathy A. Alessi MD & Jennifer L. Martin PhD
  3. Division of Pulmonary Medicine, Veterans Affairs Greater Los Angeles Healthcare System, Los North Hills, California, USA
    Michelle R. Zeidler MD
  4. Department of Emergency Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Caitlin L. Oldenkamp MD
  5. University of California, San Diego, San Diego, California, USA
    Sonia Ancoli-Israel PhD
  6. Wayne State University, Detroit, Michigan, USA
    M. Safwan Badr MD, MBA
  7. John D. Dingell Veterans Affairs Medical Center, Detroit, Michigan, USA
    M. Safwan Badr MD, MBA

Authors

  1. Monica R. Kelly PhD
  2. Michelle R. Zeidler MD
  3. Sharon DeCruz MD
  4. Caitlin L. Oldenkamp MD
  5. Karen R. Josephson MPH
  6. Michael N. Mitchell PhD
  7. Michael Littner MD
  8. Sonia Ancoli-Israel PhD
  9. M. Safwan Badr MD, MBA
  10. Cathy A. Alessi MD
  11. Jennifer L. Martin PhD

Corresponding author

Correspondence toJennifer L. Martin PhD.

Additional information

Address correspondence to: Jennifer L. Martin, PhD, VA Sepulveda Ambulatory Care Center, 16111 Plummer Street (11E), North Hills, CA 91343; Email:Jennifer.Martin@VA.gov

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Kelly, M., Zeidler, M., DeCruz, S. et al. Actigraphy prior to Multiple Sleep Latency Test: nighttime total sleep time predicts sleep-onset latency.J Clin Sleep Med 18, 161–170 (2022). https://doi.org/10.5664/jcsm.9528

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