Jagadish Babu Konda | University of Delhi (original) (raw)
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Papers by Jagadish Babu Konda
Acs Medicinal Chemistry Letters, 2010
The exclusive distribution of 5-HT 6 receptors in the brain regions associated with learning and ... more The exclusive distribution of 5-HT 6 receptors in the brain regions associated with learning and memory makes it an ideal target for cognitive disorders. A novel series of 5-piperazinyl methyl-N 1 -aryl sulfonyl indoles were designed and synthesized as 5-HT 6 R ligands. Most of the synthesized compounds are potent when tested by in vitro radioligand binding assay. The lead compound from the series does not have the CYP liabilities and is active in an animal model of cognition.
Acs Medicinal Chemistry Letters, 2010
The exclusive distribution of 5-HT 6 receptors in the brain regions associated with learning and ... more The exclusive distribution of 5-HT 6 receptors in the brain regions associated with learning and memory makes it an ideal target for cognitive disorders. A novel series of 5-piperazinyl methyl-N 1 -aryl sulfonyl indoles were designed and synthesized as 5-HT 6 R ligands. Most of the synthesized compounds are potent when tested by in vitro radioligand binding assay. The lead compound from the series does not have the CYP liabilities and is active in an animal model of cognition.