Chronic Inflammation and Pathogenesis of GI and Pancreatic Cancers (original) (raw)

• Agoff, S.N. et al. (2000). The role of cyclooxygenase 2 in ulcerative colitis-associated neoplasia. Am. J. Pathol. 157: 737–745.
  Article PubMed CAS Google Scholar
• Arico, S. et al. (2001). The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway. J. Biol. Chem. 276: 35243–35246.
  Article PubMed CAS Google Scholar
• Atkins, M.B. et al. (2004). Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma. J. Clin. Oncol. 22: 909–918.
  Article PubMed CAS Google Scholar
• Baldwin, Jr., A.S. (1996). The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu. Rev. Immunol. 14: 649–683.
  Article PubMed CAS Google Scholar
• Balkwill, F. and Mantovani, A. (2001). Inflammation and cancer: back to Virchow? Lancet 357: 539–545.
  Article PubMed CAS Google Scholar
• Bing, R.J. et al. (2001). Nitric oxide, prostanoids, cyclooxygenase, and angiogenesis in colon and breast cancer. Clin. Cancer Res. 7: 3385–3392.
  PubMed CAS Google Scholar
• Bold, R.J. et al. (1997). Apoptosis, cancer and cancer therapy. Surg. Oncol. 6: 133–142.
  Article PubMed CAS Google Scholar
• Brunner, T.B. et al. (2003). Farnesyltransferase inhibitors: an overview of the results of preclinical and clinical investigations. Cancer Res. 63: 5656–5668.
  PubMed CAS Google Scholar
• Cantley, L.C. and Neel, B.G. (1999). New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc. Natl Acad. Sci. U. S. A. 96: 4240–4245.
  Article PubMed CAS Google Scholar
• Celik, E. et al. (2003). Case report: early arising Marjolin’s ulcer in the scalp. Ann. Burn Fire Dis. 16: 217–220.
  Google Scholar
• Correa, P et al. (2000). Chemoprevention of gastric dysplasia: randomized trial of antioxidant supplements and anti-helicobacter pylori therapy. J. Natl Cancer Inst. 92: 1881–1888.
  Article PubMed CAS Google Scholar
• Correa, P. (2003). Bacterial infections as a cause of cancer. J. Natl Cancer. Inst. 95: E3.
  Article PubMed Google Scholar
• Cotran, R.S. et al. (1999). Pathologic Basis of Disease (W.B. Saunders Company, Philadelphia).
  Google Scholar
• Coussens, L.M. and Werb, Z. (2002). Inflammation and cancer. Nature 420: 860–867.
  Article PubMed CAS Google Scholar
• DuBois, R.N. et al. (1996). Nonsteroidal anti-inflammatory drugs, eicosanoids, and colorectal cancer prevention. Gastroenterol. Clin. North Am. 25: 773–791.
  Article PubMed CAS Google Scholar
• Dvorak, H.F. (1986). Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N. Engl. J. Med. 315: 1650–1659.
  Article PubMed CAS Google Scholar
• Eaden, J. A. et al. (2001). The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut 48: 526–535.
  Article PubMed CAS Google Scholar
• Ethridge, R.T. et al. (2002a). Cyclooxygenase-2 gene disruption attenuates the severity of acute pancreatitis and pancreatitis-associated lung injury. Gastroenterology 123: 1311–1322.
  Article PubMed CAS Google Scholar
• Ethridge, R.T. et al. (2002b). Selective inhibition of NF-kappaB attenuates the severity of cerulein-induced acute pancreatitis. J. Am. Coll. Surg. 195: 497–505.
  Article PubMed Google Scholar
• Farrow, B. and Evers, B.M. (2002). Inflammation and the development of pancreatic cancer. Surg. Oncol. 10: 153–169.
  Article PubMed Google Scholar
• Farrow, B. et al. (2004). Inflammatory mechanisms contributing to pancreatic cancer development. Ann. Surg. 239: 763–769.
  Article PubMed Google Scholar
• Fitzgerald, G.A. (2004). Coxibs and cardiovascular disease. N. Engl. J. Med. 351: 1709–1711.
  Article PubMed CAS Google Scholar
• Gasche, C. et al. (2001). Oxidative stress increases frameshift mutations in human colorectal cancer cells. Cancer Res. 61: 7444–7448.
  PubMed CAS Google Scholar
• Giardiello, F.M. et al. (1993). Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis. N. Engl. J. Med. 328: 1313–1316.
  Article PubMed CAS Google Scholar
• Greten, F.R. et al. (2004). IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118: 285–296.
  Article PubMed CAS Google Scholar
• Gustin, J. A. et al. (2004). Cell type-specific expression of the IkappaB kinases determines the significance of phosphatidylinositol 3-kinase/Akt signaling to NF-kappa B activation. J. Biol. Chem. 279: 1615–1620.
  Article PubMed CAS Google Scholar
• Hasuwa, H. et al. (2002). Small interfering RNA and gene silencing in transgenic mice and rats. FEBS Lett. 532: 227–230.
  Article PubMed CAS Google Scholar
• Hersey, P. and Zhang, X.D. (2003). Overcoming resistance of cancer cells to apoptosis. J. Cell Physiol. 196: 9–18.
  Article PubMed CAS Google Scholar
• Hussain, S.P. et al. (2000). Increased p53 mutation load in noncancerous colon tissue from ulcerative colitis: a cancer-prone chronic inflammatory disease. Cancer Res. 60: 3333–3337.
  PubMed CAS Google Scholar
• Itzkowitz, S.H. and Yio, X. (2004). Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation. Am. J. Physiol. Gastrointest. Liver Physiol. 287: G7–G17.
  Article PubMed CAS Google Scholar
• Jobin, C. et al. (1998). Specific NF-kappaB blockade selectively inhibits tumour necrosis factor-alpha-induced COX-2 but not constitutive COX-1 gene expression in HT-29 cells. Immunology 95: 537–543.
  Article PubMed CAS Google Scholar
• Khaleghpour, K. et al. (2004). Involvement of the PI 3-kinase signaling pathway in progression of colon adenocarcinoma. Carcinogenesis 25: 241–248.
  Article PubMed CAS Google Scholar
• Kim, S. et al. (2002). PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-kappaB-dependent pathway. Gastroenterology 123: 1163–1178.
  Article PubMed CAS Google Scholar
• Kim, S. et al. (2004). Down-regulation of the tumor suppressor PTEN by the tumor necrosis factor-alpha/nuclear factor-kappaB (NF-kappaB)-inducing kinase/NF-kappaB pathway is linked to a default IkappaB-alpha autoregulatory loop. J. Biol. Chem. 279: 4285–4291.
  Article PubMed CAS Google Scholar
• Labayle, D. et al. (1991). Sulindac causes regression of rectal polyps in familial adenomatous polyposis. Gastroenterology 101: 635–639.
  PubMed CAS Google Scholar
• Lichtenstein, G.R. (2002). Reduction of colorectal cancer risk in patients with Crohn’s disease. Rev. Gastroenterol. Disord. 2(Suppl. 2): S16–S24.
  PubMed Google Scholar
• Lowenfels, A.B. et al. (1993). Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group. N. Engl. J. Med. 328: 1433–1437.
  Article PubMed CAS Google Scholar
• Luo, J.L. et al. (2004). Inhibition of NF-kappaB in cancer cells converts inflammation-induced tumor growth mediated by TNFalpha to TRΛIL-mediated tumor regression. Cancer Cell 6: 297–305.
  Article PubMed CAS Google Scholar
• Mantovani, A. et al. (1992). The origin and function of tumor-associated macrophages. Immunol. Today 13: 265–270.
  Article PubMed CAS Google Scholar
• May, M.J. and Ghosh, S. (1998). Signal transduction through NF-kappa B. Immunol. Today 19: 80–88.
  Article PubMed CAS Google Scholar
• McCawley, L.J. and Matrisian, L.M. (2001). Tumor progression: defining the soil round the tumor seed. Curr. Biol. 11: R25–R27.
  Article PubMed CAS Google Scholar
• Mendelsohn, J. and Baselga, J. (2003). Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer. J. Clin. Oncol. 21: 2787–2799.
  Article PubMed CAS Google Scholar
• Moore, R.J. et al. (1999). Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis. Nat. Med. 5: 828–831.
  Article PubMed CAS Google Scholar
• Murano, M. et al. (2000). Therapeutic effect of intracolonically administered nuclear factor kappa B (p65) antisense oligonucleotide on mouse dextran sulphate sodium (DSS)-induced colitis. Clin. Exp. Immunol. 120: 51–58.
  Article PubMed CAS Google Scholar
• Oshima, M. et al. (1996). Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell 87: 803–809.
  Article PubMed CAS Google Scholar
• Ozes, O. N. et al. (1999). NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 401: 82–85.
  Article PubMed CAS Google Scholar
• Parsonnet, J. et al. (1991). Helicobacter pylori infection in intestinal-and diffuse-type gastric adenocarcinomas. J. Natl Cancer Inst. 83: 640–643.
  Article PubMed CAS Google Scholar
• Schwartz, S.A. et al. (1999). The role of NF-kappaB/IkappaB proteins in cancer: implications for novel treatment strategies. Surg. Oncol. 8: 143–153.
  Article PubMed CAS Google Scholar
• Sekulic, A. et al. (2000). A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res. 60: 3504–3513.
  PubMed CAS Google Scholar
• Semba, S. et al. (2002). The in vitro and in vivo effects of 2-(4-morpholinyl)-8-phenyl-chromone (LY294002), a specific inhibitor of phosphatidylinositol 3’-kinase, in human colon cancer cells. Clin. Cancer Res. 8: 1957–1963.
  PubMed CAS Google Scholar
• Shao, J. et al. (2000). Regulation of constitutive cyclooxygenase-2 expression in colon carcinoma cells. J. Biol. Chem. 275: 33951–33956.
  Article PubMed CAS Google Scholar
• Sheng, H. et al. (1997). Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. J. Clin. Invest. 99: 2254–2259.
  Article PubMed CAS Google Scholar
• Sheng, H. et al. (2003). Phosphatidylinositol 3-kinase mediates proliferative signals in intestinal epithelial cells. Gut 52: 1472–1478.
  Article PubMed CAS Google Scholar
• Shi, Q. et al. (1999). Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic, Clin. Cancer Res. 5: 3711–3721.
  PubMed CAS Google Scholar
• Slogoff, M.I. et al. (2004). COX-2 inhibition results in alterations in nuclear factor (NF)-kappaB activation but not cytokine production in acute pancreatitis. J. Gastrointest. Surg. 8: 511–519.
  Article PubMed Google Scholar
• Stein, R.C. and Waterfield, M.D. (2000). PI3-kinase inhibition: a target for drug development? Mol. Med. Today 6: 347–357.
  Article PubMed CAS Google Scholar
• Stoicov, C. et al. (2004). Molecular biology of gastric cancer: Helicobacter infection and gastric adenocarcinoma: bacterial and host factors responsible for altered growth signaling. Gene 341: 1–17.
  Article PubMed CAS Google Scholar
• Stolte, M. and Meining, A. (1998). Helicobacter pylori and Gastric Cancer. Oncologist 3: 124–128.
  PubMed Google Scholar
• Suganuma, M. et al. (1999). Essential role of tumor necrosis factor alpha (TNF-alpha) in tumor promotion as revealed by TNF-alpha-deficient mice. Cancer Res. 59: 4516–4518.
  PubMed CAS Google Scholar
• Sun, Y. et al. (2002). Cyclooxygenase-2 overexpression reduces apoptotic susceptibility by inhibiting the cytochrome c-dependent apoptotic pathway in human colon cancer cells. Cancer Res. 62: 6323–6328.
  PubMed CAS Google Scholar
• Talapatra, S. and Thompson, C.B. (2001). Growth factor signaling in cell survival: implications for cancer treatment. J. Pharmacol. Exp. Ther. 298: 873–878.
  PubMed CAS Google Scholar
• Thun, M.J. et al. (1991). Aspirin use and reduced risk of fatal colon cancer. N. Engl. J. Med. 325: 1593–1596.
  Article PubMed CAS Google Scholar
• Thun, M.J. et al. (2002). Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues. J. Natl Cancer Inst. 94: 252–266.
  Article PubMed CAS Google Scholar
• Tiscornia, G. et al. (2003). A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA. Proc. Natl Acad. Sci. U. S. A. 100: 1844–1848.
  Article PubMed CAS Google Scholar
• Tricot, G. (2000). New insights into role of microenvironment in multiple myeloma. Lancet 355: 248–250.
  Article PubMed CAS Google Scholar
• Uemura, N. et al. (1997). Effect of Helicobacter pylori eradication on subsequent development of cancer after endoscopic resection of early gastric cancer. Cancer Epidemiol. Biomarkers Prev. 6: 639–642.
  PubMed CAS Google Scholar
• Uemura, N. et al. (2001). Helicobacter pylori infection and the development of gastric cancer. N. Engl. J. Med. 345: 784–789.
  Article PubMed CAS Google Scholar
• Vidal-Vanaclocha, F. et al. (2000). IL-18 regulates IL-1beta-dependent hepatic melanoma metastasis via vascular cell adhesion molecule-1. Proc. Natl Acad. Sci. U. S. A. 97: 734–739.
  Article PubMed CAS Google Scholar
• Wang, Q. et al. (2002a). Augmentation of sodium butyrate-induced apoptosis by phosphatidylinositol 3’-kinase inhibition in the KM20 human colon cancer cell line. Clin. Cancer Res. 8: 1940–1947.
  PubMed CAS Google Scholar
• Wang, Q. et al. (2002b). Regulation of TRAIL expression by the phosphatidylinositol 3-kinase/Akt/GSK-3 pathway in human colon cancer cells. J. Biol. Chem. 277: 36602–36610.
  Article PubMed CAS Google Scholar
• Wang, W. et al. (1999). The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. Clin. Cancer Res. 5: 119–127.
  PubMed CAS Google Scholar
• Weaver, S.A. and Ward, S.G. (2001). Phosphoinositide 3-kinases in the gut: a link between inflammation and cancer? Trends Mol. Med. 7: 455–462.
  Article PubMed CAS Google Scholar
• Yamamoto, Y. and Gaynor, R.B. (2001). Therapeutic potential of inhibition of the NFkappaB pathway in the treatment of inflammation and cancer. J. Clin. Invest. 107: 135–142.
  Article PubMed CAS Google Scholar