- Aas PA, Otterlei M, Faines PO, Vagbo CB, Skorpen F, Akbari M, Sundheim O, Bjoras M, Slupphaug G, Seeberg E, and Krokan HE. Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA._Nature_421: 859–863, 2003.
Article CAS PubMed Google Scholar
- Arthur PG, Giles JJ, and Wakeford CM. Protein synthesis during oxygen conformance and severe hypoxia in the mouse muscle cell line C2C12. Biochim Biophys Acta 1475: 83–89, 2000.
Article CAS PubMed Google Scholar
- Aw TY, Anderssen BS, and Jones DP. Suppression of mitochondrial respiratory function after short-term anoxia._Am J Physiol_252: C362–C368, 1987.
CAS PubMed Google Scholar
- Bernardi P, Petronilli V, Di Lisa F, and Forte M. A mitochondrial perspective on cell death._Trends Biochem Sci_26: 112–117, 2001.
Article CAS PubMed Google Scholar
- Boutilier RG, and St-Pierre J. Adaptive plasticity of skeletal muscle energetics in hibernating frogs: mitochondrial proton leak during metabolic depression._J Exp Biol_205: 2287–2296, 2002.
CAS PubMed Google Scholar
- Boveris A. Mitochondrial production of superoxide radical and hydrogen peroxide. In: Reivich, M., Coburn, R., Lahiri, S., Chance, B. (Eds.)._Tissue Hypoxia and Ischemia._Stuttgart: Thieme, p. 67–82, 1977
Chapter Google Scholar
- Boveris A, and Cadenas E. Mitochondrial production of hydrogen peroxide. Regulation by nitric oxide and the role of ubisemiquinone._Life_50: 245–250, 2000.
CAS PubMed Google Scholar
- Brown G. Regulation of mitochondr ial respiration by nitric oxide inhibition of cytochrome_c_oxidase._Biochim Biophys Acta_1504: 46–57, 2001.
Article CAS PubMed Google Scholar
- Budinger GRS, Chandel N, Shao ZH, Li CQ, Melmed A, Becker LB, and Schumacker PT. Cellular energy utilization and supply during hypoxia in embryonic cardiac myocytes._Am J Physiol_270: L44–L53, 1996.
CAS PubMed Google Scholar
- Budinger GRS, Duranteau J, Chandel N, and Schumacker PT. Hibernation during hypoxia in cardiomyocytes. Role of mitochondria as the O2 _sensor. J Biol Chem_273: 3320–3326, 1998.
Article CAS PubMed Google Scholar
- Casey TM, and Arthur PG. Hibernation in noncontracting mammalian cardiomyocytes._Circulation_102: 3124–3129, 2000.
Article CAS PubMed Google Scholar
- Casey TM, Pakay JL, Guppy M, and Arthur PG. Hypoxia causes downregulation of protein and RNA synthesis in noncontracting mammalian cardiomyocytes._Circ Res_90: 777–783, 2002.
Article CAS PubMed Google Scholar
- Cai J, and Jones DP. Superoxide in apoptosis._J Biol Chem_273: 11401–11404, 1998.
Article CAS PubMed Google Scholar
- Chandel NS, Budinger GRS, Choe SH, and Schumacker PT. Cellular respiration during hypoxia. Role of cytochrome oxidase as the oxygen sensor in hepatocytes._J Biol Chem_272: 18808–18816, 1997.
Article CAS PubMed Google Scholar
- Chandel N, Budinger GRS, Kemp RA, and Schumacker PT. Inhibition of cytochrome-c oxidase activity during prolonged hypoxia. _Am J Physiol_268: L918–L925, 1995.
CAS PubMed Google Scholar
- Chandel NS, Budinger GRS, and Schumacker PT. Molecular oxygen modulates cytochrome_c_oxidase function. _J Biol Chem_271: 18672–18677, 1996.
Article CAS PubMed Google Scholar
- Chandel NS; and Schumacker PT. Cellular oxygen sensing by mitochondria: old questions, new insight. _J Appl Physiol_88: 1880–1889, 2000.
Article CAS PubMed Google Scholar
- Drahota Z, Chowdhury SKR, Floryk D, Mrácek T, Wilhelm J, Rauchova H, Lenaz G, and Houstek J. Glycerophosphate-dependent hydrogen peroxide production by brown adipose tissue mitochondria and its activation by ferricyanide. _J Bioenerg Biomembr_34: 105–113, 2002.
Article CAS PubMed Google Scholar
- Erecinska M, and Silver IA. Tissue oxygen tension and brain sensitivity to hypoxia. _Respir Physiol_128: 263–276, 2001.
Article CAS PubMed Google Scholar
- Fridovich I. Oxygen toxicity: a radical explanation. _J Exp Biol_201: 1203–1209, 1998.
CAS PubMed Google Scholar
- Gnaiger E. Homeostatic and microxic regulation of respiration in transitions to anaerobic metabolism. In: Bicudo J.E.P.W. (ed.) _The vertebrate gas transport cascade: Adaptations to environment and mode of life._Boca Raton, Ann Arbor, London, Tokyo: CRC Press, 358–370, 1993.
Google Scholar
- Gnaiger E. Bioenergetics at low oxygen: dependence of respiration and phosphorylation on oxygen and adenosine diphosphate supply. _Respir Physiol_128: 277–297, 2001.
Article CAS PubMed Google Scholar
- Gnaiger E, and Kuznetsov AV. Mitochondrial respiration at low levels of oxygen and cytochrome _c. Biochem Soc Trans_30: 252–258, 2002.
Article CAS Google Scholar
- Gnaiger E, Kuznetsov AV, Schneeberger S, Seiler R, Brandacher G, Steurer W, and Margreiter R. Mitochondria in the cold. In: Heldmaier G., Klingenspor M. (eds) _Life in the Cold._Heiderlberg, Berlin, New York: Springer, 2000, p. 431–442
Chapter Google Scholar
- Gnaiger E, Lassnig B, Kuznetsov AV, and Margreiter R. Mitochondrial respiration in the low oxygen environment of the cell: Effect of ADP on oxygen kinetics. _Biochim Biophys Acta_1365:249–254, 1998.
Article CAS PubMed Google Scholar
- Gnaiger E, Lassnig B, Kuznetsov AV, Rieger G, and Margreiter R. Mitochondrial oxygen affinity, respiratory flux control, and excess capacity of cytochrome _c_oxidase. _J Exp Biol_201: 1129–1139, 1998.
CAS PubMed Google Scholar
- Gnaiger E, Méndez G, and Hand SC. High phosphorylation efficiency and depression of uncoupled respiration in mitochondria under hypoxia. _Proc Natl Acad Sci USA_97: 11080– 11085, 2000.
Article CAS PubMed Central PubMed Google Scholar
- Gnaiger E, Steinlechner R, Méndez G, Eberl T, and Margreiter R. Control of mitochondrial and cellular respiration by oxygen. _J Bioenerg Biomembr_27: 583–596, 1995.
Article CAS PubMed Google Scholar
- Heerlein K, Schulze A, Bärtsch P, and Mairbäurl H. Hypoxia reduces cellular oxygen consumption and Na/K-ATPase activity of alveolar epithelial cells. _High Altitude Med Biol_3:449, 2002.
Google Scholar
- Helmlinger G, Yuan F, Dellian M, and Jain RK. Interstitial pH and_p_O2gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation. _Nature Medicine_3: 177–182, 1997.
Article CAS PubMed Google Scholar
- Hochachka PW, Buck LT, Doll CJ, and Land SC. Unifying theory of hypoxia tolerance: Molecular/ metabolic defense and rescue mechanisms for surviving oxygen lack. _Proc Natl Acad Sci USA_93: 9493–9498, 1996.
Article CAS PubMed Central PubMed Google Scholar
- Hochachka PW, Lutz PL, Sick T, Rosenthal M, and Van den Thillart G. (eds) Surviving Hypoxia: Mechanisms of Control and Adaptation. Boca Raton, Ann Arbor, London, Tokyo: CRC Press, 1993.
Google Scholar
- Hütter E, Renner K, Jansen-Dürr P, and Gnaiger E. Biphasic oxygen kinetics of cellular respiration and linear oxygen dependence of antimycin A inhibited oxygen consumption. _Molec Biol Rep_29: 83–87, 2002.
Article Google Scholar
- Jackson MJ, Papa S, Bolanos J, Bruckdorfer R, Carlsen H, Elliott RM, Flier J, Griffiths HR, Heales S, Hoist B, Lorusso M, Lund E, Moskaug JO, Moser U, Di Paola M, Polidori MC, Signorile A, Stahl W, Vina-Ribes J, and Astley SB. Antioxidants, reactive oxygen and nitrogen species, gene induction and mitochondrial function._Molec Aspects Med_23: 209–285, 2002.
Article CAS Google Scholar
- Jones DP, and Kennedy FG. Analysis of intracellular oxygenation of isolated adult cardiac myocytes. _Am J Physiol_250: C384–C390, 1986.
CAS PubMed Google Scholar
- Kennedy FG, and Jones DP. Oxygen dependence of mitochondrial function in isolated rat cardiac myocytes. _Am J Physiol_250: C374–C383, 1986.
CAS PubMed Google Scholar
- Kietzmann T, Fandrey J, and Acker H. Oxygen radicals as messengers in oxygen-dependent gene expression. _News Physiol Sci_15: 202–208, 2000.
CAS PubMed Google Scholar
- Kongas O, Yuen TL, Wagner MJ, van Beek JHGM, and Krab K. High_K_ mof oxidative phosphorylation for ADP in skinned muscle fibers: where does it stem from? Am J Physiol 283: C743–C751, 2002.
CAS Google Scholar
- Kuznetsov AV, Lassnig B, Margreiter R, and Gnaiger E. Diffusion limitation of oxygen versus ADP in permeabilized muscle fibers. In: Larsson C, Påhlman I.-L, and Gustafsson L, (eds) BioThermoKinetics in the Post Genomic Era. Göteborg: Chalmers Reproservice, 1998, p.273–276
Google Scholar
- Lassnig B, Kuznetsov AV, Margreiter R, and Gnaiger E. Aerobic-anoxic transitions and regulation of mitochondrial oxygen flux. In: Larsson C, Påhlman I.-L, and Gustafsson L, (eds) _BioThermoKinetics in the Post Genomic Era._Göteborg: Chalmers Reproservice, 1998, p.312–316
Google Scholar
- Lefebvre VHL, Steenbrugge MV, Beckers V, Roberfroid M, and Buc-Calderon VHL. Adenine nucleotides and inhibition of protein synthesis in isolated hepatocytes incubated under different_p_O2levels. Arch Biochem Biophys 304: 322–331, 1993.
Article CAS PubMed Google Scholar
- Lemasters JJ, and Nieminen A-L. Mitochondrial oxygen radical formation during reductive and oxidative stress to intact hepatocytes. _Biosci Rep_17: 281–291, 1997.
Article CAS PubMed Google Scholar
- Metzen E, Wolff M, Fandrey J, and Jelkmann W. Pericellular_p_O2and O2consumption in monolayer cultures. _Respir Physiol_100: 101–106, 1995.
Article CAS PubMed Google Scholar
- Michelakis ED, Hampl V, Nsair A, Wu X, Harry G, Haromy A, Gurtu R, and Archer SL. Diversity in mitochondrial function explains differences in vascular oxygen sensing. _Circ Res_90: 1307–1315, 2002.
Article CAS PubMed Google Scholar
- Miller WM, Wilke CR, and Blanch HW. Effects of dissolved oxygen concentration on hybridoma growth and metabolism in continuous culture. _J Cell Physiol_132: 524–530, 1987.
Article CAS PubMed Google Scholar
- Mootha VK, Arai AE, and Balaban RS. Maximum oxidative phosphorylation capacity of the mammalian heart. _Am J Physiol_272: H769–H775, 1997.
CAS PubMed Google Scholar
- Noll T, Koop A, and Piper HM. Mitochondrial ATP-synthase activity in cardiomyocytes after aerobic-anaerobic metabolic transitions. _Am J Physiol_262: C1297–C1303, 1992.
CAS PubMed Google Scholar
- Renner K, Kofler R, and Gnaiger E. Mitochondrial function in glucocorticoid triggered T-ALL cells with transgenic Bcl-2 expression. _Molec Biol Rep_29: 97–101, 2002.
Article CAS Google Scholar
- Rich P. Chemiosmotic coupling: The cost of living. _Nature_241: 583, 2003.
Article Google Scholar
- Rolfe DFS, and Brown GC. Cellular energy utilization and molecular origin of standard metabolic rate in mammals._Physiol Rev_71: 731–758, 1997.
Google Scholar
- Rumsey WL, Schlosser C, Nuutinen EM, Robiolio M, and Wilson DF. Cellular energetics and the oxygen dependence of respiration in cardiac myocytes isolated from adult rat. _J Biol Chem_265: 15392–15402, 1990.
CAS PubMed Google Scholar
- Saks VA, Belikova YO, and Kuznetsov AV._In vivo_regulation of mitochondrial respiration in cardiomyocytes: specific restrictions for intracellular diffusion of ADP. _Biochim Biophys Acta_1074:302–311, 1991.
Article CAS PubMed Google Scholar
- Sarkela TM, Berthiaume J, Elfering S, Gybina AA, and Giulivi C. The modulation of oxygen radical production by nitric oxide in mitochondria. J Biol Chem 276: 6945–6949, 2001.
Article CAS PubMed Google Scholar
- Schumacker PT, Chandel N, and Agusti AGN. Oxygen conformance of cellular respiration in hepatocytes._Am J Physiol_265: L395–L402, 1993.
CAS PubMed Google Scholar
- Sedmera D, Kucera P, and Raddatz E. Developmental changes in cardiac recovery from anoxia-reoxygenation. Am J Physiol 283: R379–R388, 2002.
CAS Google Scholar
- Sies H. Oxygen gradients during hypoxic steady states in liver. _Hoppe Seylers Z Physiol Chem_358: 1021–1032, 1977.
Article CAS PubMed Google Scholar
- Silverman HS, Wei S-K, Haigney MCP, Ocampo CJ, and Stern MD. Myocyte adaptation to chronic hypoxia and development of tolerance to subsequent acute severe hypoxia. _Circ Res_80: 699–707, 1997.
Article CAS PubMed Google Scholar
- Skulachev VP. Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants. _Quart Rev Biophys_29: 169–202, 1996.
Article CAS Google Scholar
- Stadlmann S, Rieger G, Amberger A, Kuznetsov AV, Margreiter R, and Gnaiger E. H2O2- mediated oxidative stress versus cold ischemia-reperfusion: mitochondrial respiratory defects in cultured human endothelial cells. _Transplantation_74: 1800–1803, 2002.
Article CAS PubMed Google Scholar
- Stary CM, and Hogan MC. Effect of varied extracellular_p_O2on muscle performance in_Xenopus_single skeletal muscle fibers. _JAppl Physiol_86: 1812–1816, 1999.
CAS Google Scholar
- Steinlechner-Maran R, Eberl T, Kunc M, Margreiter R, and Gnaiger E. Oxygen dependence of respiration in coupled and uncoupled endothelial cells. _Am J Physiol_271: C2053–C2061, 1996.
CAS PubMed Google Scholar
- Stumpe T, and Schrader J. Phosphorylation potential, adenosine formation, and critical_p_O2in stimulated rat cardiomyocytes. _Am J Physiol_273: H756–H766, 1997.
CAS PubMed Google Scholar
- Stumpe T, and Schrader J. Short-term hibernation in adult cardiomyocytes is_p_O2dependent and Ca2+mediated. Am J Physiol 280: H42–H50, 2001.
CAS Google Scholar
- Takahashi E, Endoh H, and Doi K. Visualization of myoglobin-facilitated mitochondrial O2delivery in a single isolated cardiomyocyte._Biophys J_78: 3252–3259, 2000.
Article CAS PubMed Central PubMed Google Scholar
- Taylor DE, Kantrow SP, and Piantadosi CA. Mitochondrial respiration after sepsis and prolonged hypoxia. _Am J Physiol_275: L139–L144, 1998.
CAS PubMed Google Scholar
- Taylor WG, and Camalier RF. Modulation of epithelial cell proliferation in culture by dissolved oxygen. _J Cell Physiol_111:21–27, 1982.
Article CAS PubMed Google Scholar
- Tiivel T, Kadaya L, Kuznetsov A, Kaambre T, Peet N, Sikk P, Braun U, Ventura-Clapier R, Saks V, Seppet EK. Developmental changes in regulation of mitochondrial respiration by ADP and creatine in rat heart _in vivo. Mol Cell Biochem_208: 119–128, 2000.
Article CAS PubMed Google Scholar
- Vanderkooi JM, Erecinska M, and Silver IA. Oxygen in mammalien tissue: methods of measurement and affinities of various reactions._Am J Physiol_260: C1131–C1150, 1991.
CAS PubMed Google Scholar
- Verkhovsky MI, Morgan JE, Puustinen A., and Wikstrom M. Kinetic trapping of oxygen in cell respiration. _Nature_380: 268–270, 1996.
Article CAS PubMed Google Scholar
- Wikstrom M, and Verkhovsky MI. Proton translocation by cytochrome_c_oxidase in different phases of the catalytic cycle. _Biochim Biophys Acta_1555: 128–132, 2002.
Article CAS PubMed Google Scholar
- Wittenberg BA, and Wittenberg JB. Oxygen pressure gradients in isolated cardiac myocytes. _J Biol Chem_260: 6548–6554, 1985.
CAS PubMed Google Scholar